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Q8YFS6 (MTB1_BRUME) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Modification methylase BabI

Short name=M.BabI
EC=2.1.1.72
Alternative name(s):
Adenine-specific methyltransferase BabI
DNA methyltransferase CcrM
M.CcrMI ortholog
Gene names
Name:ccrM
Ordered Locus Names:BMEI1444
OrganismBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]
Taxonomic identifier224914 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length403 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. CcrM-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology. Essential for viability By similarity.

Catalytic activity

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

Sequence similarities

Belongs to the N(4)/N(6)-methyltransferase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 403403Modification methylase BabI
PRO_0000363193

Sequences

Sequence LengthMass (Da)Tools
Q8YFS6 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 3ABB8BE232CB72F9

FASTA40345,065
        10         20         30         40         50         60 
MALTAYLPYA VTIGTSFLRS QVIEYPMSLV RLAHELPIEA PRTAWLDSII KGDCVSALER 

        70         80         90        100        110        120 
LSDHSVDVIF ADPPYNLQLG GDLHRPDQSM VSAVDDHWDQ FESFQAYDAF TRAWLLACRR 

       130        140        150        160        170        180 
VLKPNGTIWV IGSYHNIFRV GTQLQDLGFW LLNDIVWRKT NPMPNFRGRR FQNAHETLIW 

       190        200        210        220        230        240 
ASRDQKGKGY TFNYEAMKAA NDDVQMRSDW LFPICTGSER LKDENGDKVH PTQKPEALLA 

       250        260        270        280        290        300 
RIMMASSKPG DVILDPFFGS GTTGAVAKRL GRHFVGIERE QPYIDAATAR INAVEPLGKA 

       310        320        330        340        350        360 
ELTVMTGKRA EPRVAFTSVM EAGLLRPGTV LCDERRRFAA IVRADGTLTA NGEAGSIHRI 

       370        380        390        400 
GARVQGFDAC NGWTFWHFEE NGVLKPIDAL RKIIREQMAA AGA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008917 Genomic DNA. Translation: AAL52625.1.
PIRAF3432.
RefSeqNP_540361.1. NC_003317.1.

3D structure databases

ProteinModelPortalQ8YFS6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224914.BMEI1444.

Protein family/group databases

REBASE5746. M.BmeLORF1444P.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL52625; AAL52625; BMEI1444.
GeneID1197155.
KEGGbme:BMEI1444.
PATRIC17853242. VBIBruMel92729_1610.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000125329.
KOK13581.
OMARKLHPTQ.
OrthoDBEOG6FV84T.

Enzyme and pathway databases

BioCycBMEL224914:GCJ0-1486-MONOMER.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR002941. DNA_methylase_N4/N6.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSPR00508. S21N4MTFRASE.
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS00092. N6_MTASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTB1_BRUME
AccessionPrimary (citable) accession number: Q8YFS6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names