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Q8YFS6

- MTB1_BRUME

UniProt

Q8YFS6 - MTB1_BRUME

Protein

Modification methylase BabI

Gene

ccrM

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. CcrM-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology. Essential for viability By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. N-methyltransferase activity Source: InterPro
    3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciBMEL224914:GCJ0-1486-MONOMER.

    Protein family/group databases

    REBASEi5746. M.BmeLORF1444P.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase BabI (EC:2.1.1.72)
    Short name:
    M.BabI
    Alternative name(s):
    Adenine-specific methyltransferase BabI
    DNA methyltransferase CcrM
    M.CcrMI ortholog
    Gene namesi
    Name:ccrM
    Ordered Locus Names:BMEI1444
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 403403Modification methylase BabIPRO_0000363193Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224914.BMEI1444.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YFS6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    HOGENOMiHOG000125329.
    KOiK13581.
    OMAiRKLHPTQ.
    OrthoDBiEOG6FV84T.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF01555. N6_N4_Mtase. 1 hit.
    [Graphical view]
    PRINTSiPR00508. S21N4MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8YFS6-1 [UniParc]FASTAAdd to Basket

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    MALTAYLPYA VTIGTSFLRS QVIEYPMSLV RLAHELPIEA PRTAWLDSII    50
    KGDCVSALER LSDHSVDVIF ADPPYNLQLG GDLHRPDQSM VSAVDDHWDQ 100
    FESFQAYDAF TRAWLLACRR VLKPNGTIWV IGSYHNIFRV GTQLQDLGFW 150
    LLNDIVWRKT NPMPNFRGRR FQNAHETLIW ASRDQKGKGY TFNYEAMKAA 200
    NDDVQMRSDW LFPICTGSER LKDENGDKVH PTQKPEALLA RIMMASSKPG 250
    DVILDPFFGS GTTGAVAKRL GRHFVGIERE QPYIDAATAR INAVEPLGKA 300
    ELTVMTGKRA EPRVAFTSVM EAGLLRPGTV LCDERRRFAA IVRADGTLTA 350
    NGEAGSIHRI GARVQGFDAC NGWTFWHFEE NGVLKPIDAL RKIIREQMAA 400
    AGA 403
    Length:403
    Mass (Da):45,065
    Last modified:March 1, 2002 - v1
    Checksum:i3ABB8BE232CB72F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52625.1.
    PIRiAF3432.
    RefSeqiNP_540361.1. NC_003317.1.
    WP_011005321.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL52625; AAL52625; BMEI1444.
    GeneIDi1197155.
    KEGGibme:BMEI1444.
    PATRICi17853242. VBIBruMel92729_1610.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52625.1 .
    PIRi AF3432.
    RefSeqi NP_540361.1. NC_003317.1.
    WP_011005321.1. NC_003317.1.

    3D structure databases

    ProteinModelPortali Q8YFS6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI1444.

    Protein family/group databases

    REBASEi 5746. M.BmeLORF1444P.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL52625 ; AAL52625 ; BMEI1444 .
    GeneIDi 1197155.
    KEGGi bme:BMEI1444.
    PATRICi 17853242. VBIBruMel92729_1610.

    Phylogenomic databases

    HOGENOMi HOG000125329.
    KOi K13581.
    OMAi RKLHPTQ.
    OrthoDBi EOG6FV84T.

    Enzyme and pathway databases

    BioCyci BMEL224914:GCJ0-1486-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF01555. N6_N4_Mtase. 1 hit.
    [Graphical view ]
    PRINTSi PR00508. S21N4MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiMTB1_BRUME
    AccessioniPrimary (citable) accession number: Q8YFS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3