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Q8YFR2

- KHSE_BRUME

UniProt

Q8YFR2 - KHSE_BRUME

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Protein

Homoserine kinase

Gene

thrB

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. homoserine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. threonine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Threonine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00050; UER00064.

Names & Taxonomyi

Protein namesi
Recommended name:
Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
Short name:
HKUniRule annotation
Short name:
HSKUniRule annotation
Gene namesi
Name:thrBUniRule annotation
Ordered Locus Names:BMEI1458
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Homoserine kinasePRO_0000172186Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224914.BMEI1458.

Structurei

3D structure databases

ProteinModelPortaliQ8YFR2.
SMRiQ8YFR2. Positions 5-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudomonas-type ThrB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000004810.
KOiK02204.
OMAiNAWCFEP.
OrthoDBiEOG6BW4W1.

Family and domain databases

HAMAPiMF_00301. Homoser_kinase_2.
InterProiIPR002575. Aminoglycoside_PTrfase.
IPR005280. Homoserine_kinase_ThrB.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamiPF01636. APH. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
TIGRFAMsiTIGR00938. thrB_alt. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YFR2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVYTDINEI ELGAFLRHYD IGTLTSYKGI AEGVENSNYL LHTSSGSFIL
60 70 80 90 100
TLYEKRTNRE DLPFFLGLMQ HLAKRGLECP QPVVRNDGAM IGQLAGRPAA
110 120 130 140 150
IVTFLEGMWM RRPTVAHCEA VGEGLAHMHL AGADFPMRRR NGLTLPDWRP
160 170 180 190 200
LWNLSRKCAD TVERGLVAET EADLDFLEKN WPADLPQGVI HADLFPDNAF
210 220 230 240 250
FLGDRLSGFI DFYFACTDIL AYDVAVCLNA WCFEKDFSYN RTKGAALLRG
260 270 280 290 300
YTSVRPLSEA EANALLVLAR GAAVRFMLTR LYDWLTVPAG SFVVKKDPME
310 320
YVRRMRFHRQ IESGAEYGLE MQGVAA
Length:326
Mass (Da):36,630
Last modified:March 1, 2002 - v1
Checksum:i0BE3E69B6AC11AF0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52639.1.
PIRiAD3434.
RefSeqiNP_540375.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52639; AAL52639; BMEI1458.
GeneIDi1197169.
KEGGibme:BMEI1458.
PATRICi17797043. VBIBruMel146950_0341.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52639.1 .
PIRi AD3434.
RefSeqi NP_540375.1. NC_003317.1.

3D structure databases

ProteinModelPortali Q8YFR2.
SMRi Q8YFR2. Positions 5-319.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI1458.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL52639 ; AAL52639 ; BMEI1458 .
GeneIDi 1197169.
KEGGi bme:BMEI1458.
PATRICi 17797043. VBIBruMel146950_0341.

Phylogenomic databases

HOGENOMi HOG000004810.
KOi K02204.
OMAi NAWCFEP.
OrthoDBi EOG6BW4W1.

Enzyme and pathway databases

UniPathwayi UPA00050 ; UER00064 .

Family and domain databases

HAMAPi MF_00301. Homoser_kinase_2.
InterProi IPR002575. Aminoglycoside_PTrfase.
IPR005280. Homoserine_kinase_ThrB.
IPR011009. Kinase-like_dom.
[Graphical view ]
Pfami PF01636. APH. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
TIGRFAMsi TIGR00938. thrB_alt. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiKHSE_BRUME
AccessioniPrimary (citable) accession number: Q8YFR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2002
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3