Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8YFR2

- KHSE_BRUME

UniProt

Q8YFR2 - KHSE_BRUME

Protein

Homoserine kinase

Gene

thrB

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + L-homoserine = ADP + O-phospho-L-homoserine.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. homoserine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. threonine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Threonine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00050; UER00064.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homoserine kinaseUniRule annotation (EC:2.7.1.39UniRule annotation)
    Short name:
    HKUniRule annotation
    Short name:
    HSKUniRule annotation
    Gene namesi
    Name:thrBUniRule annotation
    Ordered Locus Names:BMEI1458
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Homoserine kinasePRO_0000172186Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224914.BMEI1458.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YFR2.
    SMRiQ8YFR2. Positions 5-319.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pseudomonas-type ThrB family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000004810.
    KOiK02204.
    OMAiNAWCFEP.
    OrthoDBiEOG6BW4W1.

    Family and domain databases

    HAMAPiMF_00301. Homoser_kinase_2.
    InterProiIPR002575. Aminoglycoside_PTrfase.
    IPR005280. Homoserine_kinase_ThrB.
    IPR011009. Kinase-like_dom.
    [Graphical view]
    PfamiPF01636. APH. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    TIGRFAMsiTIGR00938. thrB_alt. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8YFR2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVYTDINEI ELGAFLRHYD IGTLTSYKGI AEGVENSNYL LHTSSGSFIL    50
    TLYEKRTNRE DLPFFLGLMQ HLAKRGLECP QPVVRNDGAM IGQLAGRPAA 100
    IVTFLEGMWM RRPTVAHCEA VGEGLAHMHL AGADFPMRRR NGLTLPDWRP 150
    LWNLSRKCAD TVERGLVAET EADLDFLEKN WPADLPQGVI HADLFPDNAF 200
    FLGDRLSGFI DFYFACTDIL AYDVAVCLNA WCFEKDFSYN RTKGAALLRG 250
    YTSVRPLSEA EANALLVLAR GAAVRFMLTR LYDWLTVPAG SFVVKKDPME 300
    YVRRMRFHRQ IESGAEYGLE MQGVAA 326
    Length:326
    Mass (Da):36,630
    Last modified:March 1, 2002 - v1
    Checksum:i0BE3E69B6AC11AF0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52639.1.
    PIRiAD3434.
    RefSeqiNP_540375.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL52639; AAL52639; BMEI1458.
    GeneIDi1197169.
    KEGGibme:BMEI1458.
    PATRICi17797043. VBIBruMel146950_0341.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52639.1 .
    PIRi AD3434.
    RefSeqi NP_540375.1. NC_003317.1.

    3D structure databases

    ProteinModelPortali Q8YFR2.
    SMRi Q8YFR2. Positions 5-319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI1458.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL52639 ; AAL52639 ; BMEI1458 .
    GeneIDi 1197169.
    KEGGi bme:BMEI1458.
    PATRICi 17797043. VBIBruMel146950_0341.

    Phylogenomic databases

    HOGENOMi HOG000004810.
    KOi K02204.
    OMAi NAWCFEP.
    OrthoDBi EOG6BW4W1.

    Enzyme and pathway databases

    UniPathwayi UPA00050 ; UER00064 .

    Family and domain databases

    HAMAPi MF_00301. Homoser_kinase_2.
    InterProi IPR002575. Aminoglycoside_PTrfase.
    IPR005280. Homoserine_kinase_ThrB.
    IPR011009. Kinase-like_dom.
    [Graphical view ]
    Pfami PF01636. APH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    TIGRFAMsi TIGR00938. thrB_alt. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiKHSE_BRUME
    AccessioniPrimary (citable) accession number: Q8YFR2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3