Reviewed, UniProtKB/Swiss-Prot Q8YFR2 (KHSE_BRUME)

Names and origin

Protein names

Recommended name:
    Homoserine kinase
      Short name=HSK
      Short name=HK
    EC=2.7.1.39

Gene names

Name:	thrB
Ordered Locus Names:	BMEI1458

Organism

Brucella melitensis [Complete proteome] [HAMAP]

Taxonomic identifier

29459 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	326 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00301
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00301
Sequence similarities	Belongs to the pseudomonas-type thrB family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 326	326	Homoserine kinase HAMAP MF_00301		PRO_0000172186

Sequences

	Sequence		Length	Mass (Da)
	Q8YFR2-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 0BE3E69B6AC11AF0	FASTA	326	36,630
	10 20 30 40 50 60 MAVYTDINEI ELGAFLRHYD IGTLTSYKGI AEGVENSNYL LHTSSGSFIL TLYEKRTNRE 70 80 90 100 110 120 DLPFFLGLMQ HLAKRGLECP QPVVRNDGAM IGQLAGRPAA IVTFLEGMWM RRPTVAHCEA 130 140 150 160 170 180 VGEGLAHMHL AGADFPMRRR NGLTLPDWRP LWNLSRKCAD TVERGLVAET EADLDFLEKN 190 200 210 220 230 240 WPADLPQGVI HADLFPDNAF FLGDRLSGFI DFYFACTDIL AYDVAVCLNA WCFEKDFSYN 250 260 270 280 290 300 RTKGAALLRG YTSVRPLSEA EANALLVLAR GAAVRFMLTR LYDWLTVPAG SFVVKKDPME 310 320 YVRRMRFHRQ IESGAEYGLE MQGVAA

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094 / Biotype 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008917 Genomic DNA. Translation: AAL52639.1.
PIR	AD3434.
RefSeq	NP_540375.1.
3D structure databases
SMR	Q8YFR2. Positions 5-319.
ModBase	Search...
Genome annotation databases
GeneID	1197169.
GenomeReviews	Gene locus BMEI1458 in contig AE008917_GR.
KEGG	bme:BMEI1458.
NMPDR	fig|224914.1.peg.1457.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG309377.
OMA	ADLFRDN.
Enzyme and pathway databases
BioCyc	BMEL224914:BMEI1458-MONOMER.
BRENDA	2.7.1.39. 277959.
Family and domain databases
HAMAP	MF_00301. Homoser_kinase_2. [Tree]
InterPro	IPR002575. APH_trans. IPR005280. Homoserine_Kinase_ThrB. IPR011009. Kinase-like_dom. [Graphical view]
Pfam	PF01636. APH. 1 hit. [Graphical view]
TIGRFAMs	TIGR00938. thrB_alt. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KHSE_BRUME

Accession

Primary (citable) accession number: Q8YFR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	March 1, 2002
Last modified:	February 9, 2010
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)