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Q8YFR2 (KHSE_BRUME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homoserine kinase

Short name=HK
Short name=HSK
EC=2.7.1.39
Gene names
Name:thrB
Ordered Locus Names:BMEI1458
OrganismBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]
Taxonomic identifier224914 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length326 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP-Rule MF_00301

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP-Rule MF_00301

Sequence similarities

Belongs to the pseudomonas-type ThrB family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Threonine biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processthreonine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

homoserine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 326326Homoserine kinase HAMAP-Rule MF_00301
PRO_0000172186

Sequences

Sequence LengthMass (Da)Tools
Q8YFR2 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 0BE3E69B6AC11AF0

FASTA32636,630
        10         20         30         40         50         60 
MAVYTDINEI ELGAFLRHYD IGTLTSYKGI AEGVENSNYL LHTSSGSFIL TLYEKRTNRE 

        70         80         90        100        110        120 
DLPFFLGLMQ HLAKRGLECP QPVVRNDGAM IGQLAGRPAA IVTFLEGMWM RRPTVAHCEA 

       130        140        150        160        170        180 
VGEGLAHMHL AGADFPMRRR NGLTLPDWRP LWNLSRKCAD TVERGLVAET EADLDFLEKN 

       190        200        210        220        230        240 
WPADLPQGVI HADLFPDNAF FLGDRLSGFI DFYFACTDIL AYDVAVCLNA WCFEKDFSYN 

       250        260        270        280        290        300 
RTKGAALLRG YTSVRPLSEA EANALLVLAR GAAVRFMLTR LYDWLTVPAG SFVVKKDPME 

       310        320 
YVRRMRFHRQ IESGAEYGLE MQGVAA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008917 Genomic DNA. Translation: AAL52639.1.
PIRAD3434.
RefSeqNP_540375.1. NC_003317.1.

3D structure databases

ProteinModelPortalQ8YFR2.
SMRQ8YFR2. Positions 5-319.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224914.BMEI1458.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL52639; AAL52639; BMEI1458.
GeneID1197169.
KEGGbme:BMEI1458.
PATRIC17797043. VBIBruMel146950_0341.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000004810.
KOK02204.
OMANAWCFEP.
OrthoDBEOG6BW4W1.

Enzyme and pathway databases

UniPathwayUPA00050; UER00064.

Family and domain databases

HAMAPMF_00301. Homoser_kinase_2.
InterProIPR002575. Aminoglycoside_PTrfase.
IPR005280. Homoserine_kinase_ThrB.
IPR011009. Kinase-like_dom.
[Graphical view]
PfamPF01636. APH. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
TIGRFAMsTIGR00938. thrB_alt. 1 hit.
ProtoNetSearch...

Entry information

Entry nameKHSE_BRUME
AccessionPrimary (citable) accession number: Q8YFR2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names