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Q8YFH6

- ATP6_BRUME

UniProt

Q8YFH6 - ATP6_BRUME

Protein

ATP synthase subunit a

Gene

atpB

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.UniRule annotation

    GO - Molecular functioni

    1. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP

    GO - Biological processi

    1. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP

    Keywords - Biological processi

    ATP synthesis, Hydrogen ion transport, Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP synthase subunit aUniRule annotation
    Alternative name(s):
    ATP synthase F0 sector subunit aUniRule annotation
    F-ATPase subunit 6UniRule annotation
    Gene namesi
    Name:atpBUniRule annotation
    Ordered Locus Names:BMEI1546
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. proton-transporting ATP synthase complex, coupling factor F(o) Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, CF(0), Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 249249ATP synthase subunit aPRO_0000362256Add
    BLAST

    Interactioni

    Subunit structurei

    F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.UniRule annotation

    Protein-protein interaction databases

    STRINGi224914.BMEI1546.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YFH6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621HelicalUniRule annotationAdd
    BLAST
    Transmembranei84 – 10421HelicalUniRule annotationAdd
    BLAST
    Transmembranei114 – 13421HelicalUniRule annotationAdd
    BLAST
    Transmembranei143 – 16321HelicalUniRule annotationAdd
    BLAST
    Transmembranei185 – 20521HelicalUniRule annotationAdd
    BLAST
    Transmembranei208 – 22821HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATPase A chain family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000253874.
    KOiK02108.
    OrthoDBiEOG6K4054.

    Family and domain databases

    Gene3Di1.20.120.220. 1 hit.
    HAMAPiMF_01393. ATP_synth_a_bact.
    InterProiIPR000568. ATPase_F0-cplx_asu.
    IPR023011. ATPase_F0-cplx_asu_AS.
    [Graphical view]
    PANTHERiPTHR11410. PTHR11410. 1 hit.
    PfamiPF00119. ATP-synt_A. 1 hit.
    [Graphical view]
    PRINTSiPR00123. ATPASEA.
    SUPFAMiSSF81336. SSF81336. 1 hit.
    TIGRFAMsiTIGR01131. ATP_synt_6_or_A. 1 hit.
    PROSITEiPS00449. ATPASE_A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8YFH6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANDPIHQFQ VSRWIPIDVG GVDLSFTNVS AFMVATVVLA SGFLYLTSSG    50
    RGLIPTRLQS VSEMAYEFVA TSLRDSAGSK GMKFFPFVFS LFMFVLVANF 100
    IGLFPYFYTV TSQIIVTFAL SLLVIGTVIF YGFFKHGFGF LKLFVPSGVP 150
    GIIVPLVVLI EIISFLSRPI SLSVRLFANM LAGHITLKVF AGFVVSLSSL 200
    GALGIGGAVL PLLMTVAITA LEFLVAFLQA YVFTVLTCMY INDAVHPGH 249
    Length:249
    Mass (Da):26,979
    Last modified:February 10, 2009 - v2
    Checksum:i0322177F778BAE6D
    GO

    Sequence cautioni

    The sequence AAC08028.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAL52727.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti171 – 1711S → T in strain: 133.
    Natural varianti189 – 1913VFA → FSP in strain: 133.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52727.1. Different initiation.
    AF054609 Genomic DNA. Translation: AAC08028.1. Different initiation.
    PIRiAD3445.
    RefSeqiNP_540463.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL52727; AAL52727; BMEI1546.
    GeneIDi1197257.
    KEGGibme:BMEI1546.
    PATRICi17796861. VBIBruMel146950_0250.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52727.1 . Different initiation.
    AF054609 Genomic DNA. Translation: AAC08028.1 . Different initiation.
    PIRi AD3445.
    RefSeqi NP_540463.1. NC_003317.1.

    3D structure databases

    ProteinModelPortali Q8YFH6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI1546.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL52727 ; AAL52727 ; BMEI1546 .
    GeneIDi 1197257.
    KEGGi bme:BMEI1546.
    PATRICi 17796861. VBIBruMel146950_0250.

    Phylogenomic databases

    HOGENOMi HOG000253874.
    KOi K02108.
    OrthoDBi EOG6K4054.

    Family and domain databases

    Gene3Di 1.20.120.220. 1 hit.
    HAMAPi MF_01393. ATP_synth_a_bact.
    InterProi IPR000568. ATPase_F0-cplx_asu.
    IPR023011. ATPase_F0-cplx_asu_AS.
    [Graphical view ]
    PANTHERi PTHR11410. PTHR11410. 1 hit.
    Pfami PF00119. ATP-synt_A. 1 hit.
    [Graphical view ]
    PRINTSi PR00123. ATPASEA.
    SUPFAMi SSF81336. SSF81336. 1 hit.
    TIGRFAMsi TIGR01131. ATP_synt_6_or_A. 1 hit.
    PROSITEi PS00449. ATPASE_A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.
    2. "Identification of four genes of the Brucella melitensis ATP synthase operon F0 sector: relationship with the Rhodospirillaceae family."
      Hernandez-Castro R., Verdugo-Rodriguez A., Gutierrez-Pabello J.A., Adams L.G., Suarez-Guemes F., Sahagun-Ruiz A.
      Microb. Comp. Genomics 5:163-171(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-249.
      Strain: 133.

    Entry informationi

    Entry nameiATP6_BRUME
    AccessioniPrimary (citable) accession number: Q8YFH6
    Secondary accession number(s): O68817
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3