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Q8YFH6

- ATP6_BRUME

UniProt

Q8YFH6 - ATP6_BRUME

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Protein

ATP synthase subunit a

Gene

atpB

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.UniRule annotation

GO - Molecular functioni

  1. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP

GO - Biological processi

  1. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit aUniRule annotation
Alternative name(s):
ATP synthase F0 sector subunit aUniRule annotation
F-ATPase subunit 6UniRule annotation
Gene namesi
Name:atpBUniRule annotation
Ordered Locus Names:BMEI1546
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621HelicalUniRule annotationAdd
BLAST
Transmembranei84 – 10421HelicalUniRule annotationAdd
BLAST
Transmembranei114 – 13421HelicalUniRule annotationAdd
BLAST
Transmembranei143 – 16321HelicalUniRule annotationAdd
BLAST
Transmembranei185 – 20521HelicalUniRule annotationAdd
BLAST
Transmembranei208 – 22821HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
  3. proton-transporting ATP synthase complex, coupling factor F(o) Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, CF(0), Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249ATP synthase subunit aPRO_0000362256Add
BLAST

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEI1546.

Structurei

3D structure databases

ProteinModelPortaliQ8YFH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase A chain family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000253874.
KOiK02108.
OrthoDBiEOG6K4054.

Family and domain databases

Gene3Di1.20.120.220. 1 hit.
HAMAPiMF_01393. ATP_synth_a_bact.
InterProiIPR000568. ATPase_F0-cplx_asu.
IPR023011. ATPase_F0-cplx_asu_AS.
[Graphical view]
PANTHERiPTHR11410. PTHR11410. 1 hit.
PfamiPF00119. ATP-synt_A. 1 hit.
[Graphical view]
PRINTSiPR00123. ATPASEA.
SUPFAMiSSF81336. SSF81336. 1 hit.
TIGRFAMsiTIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITEiPS00449. ATPASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YFH6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANDPIHQFQ VSRWIPIDVG GVDLSFTNVS AFMVATVVLA SGFLYLTSSG
60 70 80 90 100
RGLIPTRLQS VSEMAYEFVA TSLRDSAGSK GMKFFPFVFS LFMFVLVANF
110 120 130 140 150
IGLFPYFYTV TSQIIVTFAL SLLVIGTVIF YGFFKHGFGF LKLFVPSGVP
160 170 180 190 200
GIIVPLVVLI EIISFLSRPI SLSVRLFANM LAGHITLKVF AGFVVSLSSL
210 220 230 240
GALGIGGAVL PLLMTVAITA LEFLVAFLQA YVFTVLTCMY INDAVHPGH
Length:249
Mass (Da):26,979
Last modified:February 10, 2009 - v2
Checksum:i0322177F778BAE6D
GO

Sequence cautioni

The sequence AAC08028.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAL52727.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti171 – 1711S → T in strain: 133.
Natural varianti189 – 1913VFA → FSP in strain: 133.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52727.1. Different initiation.
AF054609 Genomic DNA. Translation: AAC08028.1. Different initiation.
PIRiAD3445.
RefSeqiNP_540463.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52727; AAL52727; BMEI1546.
GeneIDi1197257.
KEGGibme:BMEI1546.
PATRICi17796861. VBIBruMel146950_0250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52727.1 . Different initiation.
AF054609 Genomic DNA. Translation: AAC08028.1 . Different initiation.
PIRi AD3445.
RefSeqi NP_540463.1. NC_003317.1.

3D structure databases

ProteinModelPortali Q8YFH6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI1546.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL52727 ; AAL52727 ; BMEI1546 .
GeneIDi 1197257.
KEGGi bme:BMEI1546.
PATRICi 17796861. VBIBruMel146950_0250.

Phylogenomic databases

HOGENOMi HOG000253874.
KOi K02108.
OrthoDBi EOG6K4054.

Family and domain databases

Gene3Di 1.20.120.220. 1 hit.
HAMAPi MF_01393. ATP_synth_a_bact.
InterProi IPR000568. ATPase_F0-cplx_asu.
IPR023011. ATPase_F0-cplx_asu_AS.
[Graphical view ]
PANTHERi PTHR11410. PTHR11410. 1 hit.
Pfami PF00119. ATP-synt_A. 1 hit.
[Graphical view ]
PRINTSi PR00123. ATPASEA.
SUPFAMi SSF81336. SSF81336. 1 hit.
TIGRFAMsi TIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITEi PS00449. ATPASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.
  2. "Identification of four genes of the Brucella melitensis ATP synthase operon F0 sector: relationship with the Rhodospirillaceae family."
    Hernandez-Castro R., Verdugo-Rodriguez A., Gutierrez-Pabello J.A., Adams L.G., Suarez-Guemes F., Sahagun-Ruiz A.
    Microb. Comp. Genomics 5:163-171(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-249.
    Strain: 133.

Entry informationi

Entry nameiATP6_BRUME
AccessioniPrimary (citable) accession number: Q8YFH6
Secondary accession number(s): O68817
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3