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Protein

Pantothenate synthetase

Gene

panC

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Pantothenate synthetase (panC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei37Proton donorUniRule annotation1
Binding sitei61Beta-alanineUniRule annotation1
Binding sitei61PantoateUniRule annotation1
Binding sitei153PantoateUniRule annotation1
Binding sitei176ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 37ATPUniRule annotation8
Nucleotide bindingi147 – 150ATPUniRule annotation4
Nucleotide bindingi184 – 187ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:BMEI1593
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001282101 – 293Pantothenate synthetaseAdd BLAST293

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BAWG_0631.

Structurei

Secondary structure

1293
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 4Combined sources3
Helixi7 – 19Combined sources13
Beta strandi24 – 29Combined sources6
Helixi35 – 47Combined sources13
Beta strandi49 – 55Combined sources7
Helixi59 – 61Combined sources3
Turni68 – 70Combined sources3
Helixi75 – 84Combined sources10
Beta strandi88 – 91Combined sources4
Helixi95 – 98Combined sources4
Beta strandi106 – 108Combined sources3
Helixi110 – 113Combined sources4
Helixi117 – 120Combined sources4
Helixi124 – 139Combined sources16
Beta strandi142 – 147Combined sources6
Helixi151 – 163Combined sources13
Beta strandi169 – 173Combined sources5
Helixi186 – 190Combined sources5
Helixi193 – 198Combined sources6
Helixi201 – 215Combined sources15
Helixi220 – 230Combined sources11
Turni231 – 233Combined sources3
Beta strandi237 – 245Combined sources9
Turni247 – 249Combined sources3
Beta strandi261 – 269Combined sources9
Beta strandi272 – 280Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3INNX-ray2.10A/B/C/D1-293[»]
ProteinModelPortaliQ8YFC9.
SMRiQ8YFC9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8YFC9.

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107R03. Bacteria.
COG0414. LUCA.
HOGENOMiHOG000175517.
KOiK01918.
OMAiGAMRKGH.

Family and domain databases

CDDicd00560. PanC. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YFC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIIHTIEEL RQALAPARQQ GKKIGFVPTM GYLHKGHLEL VRRARVENDV
60 70 80 90 100
TLVSIFVNPL QFGANEDLGR YPRDLERDAG LLHDAQVDYL FAPTVSDMYP
110 120 130 140 150
RPMQTVVDVP PLGNQMEGEA RPGHFAGVAT VVSKLFNIVG PDAAYFGEKD
160 170 180 190 200
FQQLVIIRRM VDDMAIPVRI VGVETVREDD GLACSSRNVY LTPEQRRAAI
210 220 230 240 250
IVPQALDEAD RLYRSGMDDP DALEAAIRTF IGRQPLAVPE VIAIRDPETL
260 270 280 290
ERLPALQGRP ILVALFVRVG ATRLLDNRVI GHAAPQITQE RAA
Length:293
Mass (Da):32,524
Last modified:March 1, 2002 - v1
Checksum:iBF9F2C983D14E2D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52774.1.
PIRiAC3451.
RefSeqiWP_004682909.1. NZ_GG703778.1.

Genome annotation databases

EnsemblBacteriaiAAL52774; AAL52774; BMEI1593.
KEGGibme:BMEI1593.
bmel:DK63_1897.
PATRICi17796743. VBIBruMel146950_0191.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52774.1.
PIRiAC3451.
RefSeqiWP_004682909.1. NZ_GG703778.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3INNX-ray2.10A/B/C/D1-293[»]
ProteinModelPortaliQ8YFC9.
SMRiQ8YFC9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BAWG_0631.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL52774; AAL52774; BMEI1593.
KEGGibme:BMEI1593.
bmel:DK63_1897.
PATRICi17796743. VBIBruMel146950_0191.

Phylogenomic databases

eggNOGiENOG4107R03. Bacteria.
COG0414. LUCA.
HOGENOMiHOG000175517.
KOiK01918.
OMAiGAMRKGH.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.

Miscellaneous databases

EvolutionaryTraceiQ8YFC9.

Family and domain databases

CDDicd00560. PanC. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPANC_BRUME
AccessioniPrimary (citable) accession number: Q8YFC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.