Q8YFB8 (Q8YFB8_BRUME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
5-aminolevulinic acid synthase EMBL AAL52785.1
EC=2.3.1.37 EMBL AAL52785.1

Submitted name:
Aminotransferase EMBL EEW88513.1

Gene names

Ordered Locus Names:	BMEI1604
ORF Names:	BAWG_0621 EMBL EEW88513.1

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor	Pyridoxal phosphate By similarity. RuleBase RU003693
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. RuleBase RU003693

Ontologies

Keywords
Ligand	Pyridoxal phosphate RuleBase RU003693
Molecular function	Acyltransferase EMBL AAL52785.1 Aminotransferase EMBL EEW88513.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tetrapyrrole biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	5-aminolevulinate synthase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8YFB8 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: E1883455DAF19E30	FASTA	425	46,142
	10 20 30 40 50 60 MDYRRFFEEA IDQLHAEKRY RVFADLERIV GRFPQAIWRN NGTAREITVW CSNDYLGMGH 70 80 90 100 110 120 HPDVIKAMCD TAGSAGSGAG GTRNISGNNH PLVELESELA DLHGKEAGLV FTSGFVSNEA 130 140 150 160 170 180 SISTIARLLP NCLILSDELN HASMIEGVRR SGAEKKIFRH NDVEHLEQLL KAADRSRAKL 190 200 210 220 230 240 IVFESVYSMD GDIAPIEKIA DLADKYNAMT YIDEVHAVGM YGAHGGGITE RDGLAHRIDI 250 260 270 280 290 300 IEGTLAKAFG ALGGYITGSR AIIDAVRSYA PGFIFTTSLP PAVAAAATAA IRHLKSSQAE 310 320 330 340 350 360 RDGQQRQAQR AKDVLSAAGL PVMPSQTHIV PILVGDPELC KKASDRLLEV HGIYIQPINY 370 380 390 400 410 420 PTVPRGTERL RITPSPLHDD KLIDGLKDAL LEVWNELGIP FAEPSAPQAA NSDRIIPLMV SKAGG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.
[2]	"The Genome Sequence of Brucella melitensis bv. 1 str. 16M." The Broad Institute Genome Sequencing Platform Ward D., Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C. , Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Whatmore A.M., Perrett L.L., O'Callaghan D., Nusbaum C., Galagan J., Birren B. Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 16M EMBL EEW88513.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008917 Genomic DNA. Translation: AAL52785.1. GG703778 Genomic DNA. Translation: EEW88513.1.
PIR	AF3452.
RefSeq	NP_540521.1. NC_003317.1.
3D structure databases
HSSP	HSSP built from PDB template 1FC4 based on UniProtKB P07912.
ProteinModelPortal	Q8YFB8.
SMR	Q8YFB8. Positions 2-394.
ModBase	Search...
Protein-protein interaction databases
STRING	D0B539.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1197315.
GenomeReviews	Gene locus BMEI1604 in contig AE008917_GR.
KEGG	bme:BMEI1604.
PATRIC	17796721. VBIBruMel146950_0180.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG649839.
OMA	HLKESNE.
PhylomeDB	Q8YFB8.
ProtClustDB	PRK09064.
Family and domain databases
InterPro	IPR010961. 4pyrrol_synth_NH2levulA_synth. IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00643.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01821. 5aminolev_synth. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8YFB8_BRUME

Accession

Primary (citable) accession number: Q8YFB8
Secondary accession number(s): D0B539

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)