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Q8YF86

- G6PI_BRUME

UniProt

Q8YF86 - G6PI_BRUME

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Protein
Glucose-6-phosphate isomerase
Gene
pgi, BMEI1636
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei353 – 3531Proton donor By similarity
Active sitei384 – 3841 By similarity
Active sitei513 – 5131 By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:BMEI1636
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Glucose-6-phosphate isomeraseUniRule annotation
PRO_0000180609Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224914.BMEI1636.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 2117
Helixi27 – 337
Helixi37 – 404
Beta strandi42 – 454
Beta strandi48 – 514
Helixi59 – 7113
Helixi74 – 829
Turni89 – 924
Helixi97 – 1015
Helixi116 – 13520
Beta strandi136 – 1394
Beta strandi148 – 1525
Helixi155 – 1573
Helixi159 – 1679
Helixi169 – 1713
Beta strandi174 – 1807
Helixi185 – 1928
Helixi197 – 1993
Beta strandi200 – 2056
Beta strandi207 – 2093
Helixi212 – 22918
Helixi231 – 2366
Beta strandi238 – 2414
Helixi245 – 2517
Helixi255 – 2573
Helixi267 – 2693
Helixi274 – 2763
Helixi277 – 2837
Helixi285 – 30420
Helixi307 – 3093
Helixi311 – 32414
Beta strandi330 – 3367
Helixi338 – 3403
Helixi343 – 35513
Beta strandi373 – 3753
Helixi381 – 3844
Helixi387 – 3926
Beta strandi393 – 3953
Beta strandi399 – 4068
Helixi410 – 4123
Helixi413 – 43220
Helixi436 – 44510
Helixi450 – 4567
Helixi457 – 4604
Beta strandi468 – 4747
Helixi478 – 49922
Helixi507 – 5093
Helixi510 – 52314
Helixi534 – 54714

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EM6X-ray1.90A/B/C/D1-549[»]
ProteinModelPortaliQ8YF86.
SMRiQ8YF86. Positions 13-549.

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.

Phylogenomic databases

HOGENOMiHOG000261370.
KOiK01810.
OMAiRAHYVSN.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YF86-1 [UniParc]FASTAAdd to Basket

« Hide

MARDATKLEA TVAKLKKHWA ESAPRDMRAA FSADPGRFGR YSLCLDDLLF    50
DWSKCRVNDE TMALLKELAV AADVEGRRAA MFAGEHINNT EDRAVLHVAL 100
RDTSSKEVLV DGHNVLPDVK HVLDRMAAFA DGIRSGALKG ATGRKITDIV 150
NIGIGGSDLG PVMATLALAP YHDEPRAHFV SNIDGAHIAD TLSPLDPAST 200
LIIVASKTFT TIETMTNAQT ARKWVADTLG EAAVGAHFAA VSTALDKVAA 250
FGIPEDRVFG FWDWVGGRYS VWSAIGLPVM IAVGPDNFRK FLAGAHAMDV 300
HFRDAPLEKN LPVMLGLIGY WHRAICGYGS RAIIPYDQRL SRLPAYLQQL 350
DMESNGKSVT LDGKPVSGPT GPVVWGEPGT NGQHAFFQLL HQGTDTIPLE 400
FIVAAKGHEP TLDHQHEMLM ANCLAQSEAL MKGRTLDEAR AQLQAKNLPA 450
SQVERIAPHR VFSGNRPSLT LIHDMLDPYT LGRLIALYEH RVFVEAQIFG 500
INAFDQWGVE LGKELATELL PVVSGKEGAS GRDASTQGLV AHLHARRKA 549
Length:549
Mass (Da):59,642
Last modified:March 27, 2002 - v1
Checksum:iB2EFDDCE8392C968
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52817.1.
PIRiAF3456.
RefSeqiNP_540553.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52817; AAL52817; BMEI1636.
GeneIDi1197347.
KEGGibme:BMEI1636.
PATRICi17796651. VBIBruMel146950_0145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL52817.1 .
PIRi AF3456.
RefSeqi NP_540553.1. NC_003317.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4EM6 X-ray 1.90 A/B/C/D 1-549 [» ]
ProteinModelPortali Q8YF86.
SMRi Q8YF86. Positions 13-549.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEI1636.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL52817 ; AAL52817 ; BMEI1636 .
GeneIDi 1197347.
KEGGi bme:BMEI1636.
PATRICi 17796651. VBIBruMel146950_0145.

Phylogenomic databases

HOGENOMi HOG000261370.
KOi K01810.
OMAi RAHYVSN.
OrthoDBi EOG64R61J.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00181 .

Family and domain databases

Gene3Di 1.10.1390.10. 1 hit.
HAMAPi MF_00473. G6P_isomerase.
InterProi IPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view ]
PANTHERi PTHR11469. PTHR11469. 1 hit.
Pfami PF00342. PGI. 1 hit.
[Graphical view ]
PRINTSi PR00662. G6PISOMERASE.
PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiG6PI_BRUME
AccessioniPrimary (citable) accession number: Q8YF86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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