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Q8YF86

- G6PI_BRUME

UniProt

Q8YF86 - G6PI_BRUME

Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (27 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei353 – 3531Proton donorUniRule annotation
    Active sitei384 – 3841UniRule annotation
    Active sitei513 – 5131UniRule annotation

    GO - Molecular functioni

    1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-HAMAP
    2. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Gluconeogenesis, Glycolysis

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00181.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
    Short name:
    GPIUniRule annotation
    Alternative name(s):
    Phosphoglucose isomeraseUniRule annotation
    Short name:
    PGIUniRule annotation
    Phosphohexose isomeraseUniRule annotation
    Short name:
    PHIUniRule annotation
    Gene namesi
    Name:pgiUniRule annotation
    Ordered Locus Names:BMEI1636
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 549549Glucose-6-phosphate isomerasePRO_0000180609Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224914.BMEI1636.

    Structurei

    Secondary structure

    1
    549
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 2117
    Helixi27 – 337
    Helixi37 – 404
    Beta strandi42 – 454
    Beta strandi48 – 514
    Helixi59 – 7113
    Helixi74 – 829
    Turni89 – 924
    Helixi97 – 1015
    Helixi116 – 13520
    Beta strandi136 – 1394
    Beta strandi148 – 1525
    Helixi155 – 1573
    Helixi159 – 1679
    Helixi169 – 1713
    Beta strandi174 – 1807
    Helixi185 – 1928
    Helixi197 – 1993
    Beta strandi200 – 2056
    Beta strandi207 – 2093
    Helixi212 – 22918
    Helixi231 – 2366
    Beta strandi238 – 2414
    Helixi245 – 2517
    Helixi255 – 2573
    Helixi267 – 2693
    Helixi274 – 2763
    Helixi277 – 2837
    Helixi285 – 30420
    Helixi307 – 3093
    Helixi311 – 32414
    Beta strandi330 – 3367
    Helixi338 – 3403
    Helixi343 – 35513
    Beta strandi373 – 3753
    Helixi381 – 3844
    Helixi387 – 3926
    Beta strandi393 – 3953
    Beta strandi399 – 4068
    Helixi410 – 4123
    Helixi413 – 43220
    Helixi436 – 44510
    Helixi450 – 4567
    Helixi457 – 4604
    Beta strandi468 – 4747
    Helixi478 – 49922
    Helixi507 – 5093
    Helixi510 – 52314
    Helixi534 – 54714

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4EM6X-ray1.90A/B/C/D1-549[»]
    ProteinModelPortaliQ8YF86.
    SMRiQ8YF86. Positions 13-549.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GPI family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000261370.
    KOiK01810.
    OMAiRAHYVSN.
    OrthoDBiEOG64R61J.

    Family and domain databases

    Gene3Di1.10.1390.10. 1 hit.
    HAMAPiMF_00473. G6P_isomerase.
    InterProiIPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view]
    PANTHERiPTHR11469. PTHR11469. 1 hit.
    PfamiPF00342. PGI. 1 hit.
    [Graphical view]
    PRINTSiPR00662. G6PISOMERASE.
    PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8YF86-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARDATKLEA TVAKLKKHWA ESAPRDMRAA FSADPGRFGR YSLCLDDLLF    50
    DWSKCRVNDE TMALLKELAV AADVEGRRAA MFAGEHINNT EDRAVLHVAL 100
    RDTSSKEVLV DGHNVLPDVK HVLDRMAAFA DGIRSGALKG ATGRKITDIV 150
    NIGIGGSDLG PVMATLALAP YHDEPRAHFV SNIDGAHIAD TLSPLDPAST 200
    LIIVASKTFT TIETMTNAQT ARKWVADTLG EAAVGAHFAA VSTALDKVAA 250
    FGIPEDRVFG FWDWVGGRYS VWSAIGLPVM IAVGPDNFRK FLAGAHAMDV 300
    HFRDAPLEKN LPVMLGLIGY WHRAICGYGS RAIIPYDQRL SRLPAYLQQL 350
    DMESNGKSVT LDGKPVSGPT GPVVWGEPGT NGQHAFFQLL HQGTDTIPLE 400
    FIVAAKGHEP TLDHQHEMLM ANCLAQSEAL MKGRTLDEAR AQLQAKNLPA 450
    SQVERIAPHR VFSGNRPSLT LIHDMLDPYT LGRLIALYEH RVFVEAQIFG 500
    INAFDQWGVE LGKELATELL PVVSGKEGAS GRDASTQGLV AHLHARRKA 549
    Length:549
    Mass (Da):59,642
    Last modified:March 27, 2002 - v1
    Checksum:iB2EFDDCE8392C968
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52817.1.
    PIRiAF3456.
    RefSeqiNP_540553.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL52817; AAL52817; BMEI1636.
    GeneIDi1197347.
    KEGGibme:BMEI1636.
    PATRICi17796651. VBIBruMel146950_0145.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL52817.1 .
    PIRi AF3456.
    RefSeqi NP_540553.1. NC_003317.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4EM6 X-ray 1.90 A/B/C/D 1-549 [» ]
    ProteinModelPortali Q8YF86.
    SMRi Q8YF86. Positions 13-549.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI1636.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL52817 ; AAL52817 ; BMEI1636 .
    GeneIDi 1197347.
    KEGGi bme:BMEI1636.
    PATRICi 17796651. VBIBruMel146950_0145.

    Phylogenomic databases

    HOGENOMi HOG000261370.
    KOi K01810.
    OMAi RAHYVSN.
    OrthoDBi EOG64R61J.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00181 .

    Family and domain databases

    Gene3Di 1.10.1390.10. 1 hit.
    HAMAPi MF_00473. G6P_isomerase.
    InterProi IPR001672. G6P_Isomerase.
    IPR023096. G6P_Isomerase_C.
    IPR018189. Phosphoglucose_isomerase_CS.
    [Graphical view ]
    PANTHERi PTHR11469. PTHR11469. 1 hit.
    Pfami PF00342. PGI. 1 hit.
    [Graphical view ]
    PRINTSi PR00662. G6PISOMERASE.
    PROSITEi PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
    PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
    PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiG6PI_BRUME
    AccessioniPrimary (citable) accession number: Q8YF86
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: March 27, 2002
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3