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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei353Proton donorUniRule annotation1
Active sitei384UniRule annotation1
Active sitei513UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:BMEI1636
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001806091 – 549Glucose-6-phosphate isomeraseAdd BLAST549

Proteomic databases

PRIDEiQ8YF86.

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_0590.

Structurei

Secondary structure

1549
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 21Combined sources17
Helixi27 – 33Combined sources7
Helixi37 – 40Combined sources4
Beta strandi42 – 45Combined sources4
Beta strandi48 – 51Combined sources4
Helixi59 – 71Combined sources13
Helixi74 – 82Combined sources9
Turni89 – 92Combined sources4
Helixi97 – 101Combined sources5
Helixi116 – 135Combined sources20
Beta strandi136 – 139Combined sources4
Beta strandi148 – 152Combined sources5
Helixi155 – 157Combined sources3
Helixi159 – 167Combined sources9
Helixi169 – 171Combined sources3
Beta strandi174 – 180Combined sources7
Helixi185 – 192Combined sources8
Helixi197 – 199Combined sources3
Beta strandi200 – 205Combined sources6
Beta strandi207 – 209Combined sources3
Helixi212 – 229Combined sources18
Helixi231 – 236Combined sources6
Beta strandi238 – 241Combined sources4
Helixi245 – 251Combined sources7
Helixi255 – 257Combined sources3
Helixi267 – 269Combined sources3
Helixi274 – 276Combined sources3
Helixi277 – 283Combined sources7
Helixi285 – 304Combined sources20
Helixi307 – 309Combined sources3
Helixi311 – 324Combined sources14
Beta strandi330 – 336Combined sources7
Helixi338 – 340Combined sources3
Helixi343 – 355Combined sources13
Beta strandi373 – 375Combined sources3
Helixi381 – 384Combined sources4
Helixi387 – 392Combined sources6
Beta strandi393 – 395Combined sources3
Beta strandi399 – 406Combined sources8
Helixi410 – 412Combined sources3
Helixi413 – 432Combined sources20
Helixi436 – 445Combined sources10
Helixi450 – 456Combined sources7
Helixi457 – 460Combined sources4
Beta strandi468 – 474Combined sources7
Helixi478 – 499Combined sources22
Helixi507 – 509Combined sources3
Helixi510 – 523Combined sources14
Helixi534 – 547Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4EM6X-ray1.90A/B/C/D1-549[»]
ProteinModelPortaliQ8YF86.
SMRiQ8YF86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QP8. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000261370.
KOiK01810.
OMAiSHLIAPY.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YF86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARDATKLEA TVAKLKKHWA ESAPRDMRAA FSADPGRFGR YSLCLDDLLF
60 70 80 90 100
DWSKCRVNDE TMALLKELAV AADVEGRRAA MFAGEHINNT EDRAVLHVAL
110 120 130 140 150
RDTSSKEVLV DGHNVLPDVK HVLDRMAAFA DGIRSGALKG ATGRKITDIV
160 170 180 190 200
NIGIGGSDLG PVMATLALAP YHDEPRAHFV SNIDGAHIAD TLSPLDPAST
210 220 230 240 250
LIIVASKTFT TIETMTNAQT ARKWVADTLG EAAVGAHFAA VSTALDKVAA
260 270 280 290 300
FGIPEDRVFG FWDWVGGRYS VWSAIGLPVM IAVGPDNFRK FLAGAHAMDV
310 320 330 340 350
HFRDAPLEKN LPVMLGLIGY WHRAICGYGS RAIIPYDQRL SRLPAYLQQL
360 370 380 390 400
DMESNGKSVT LDGKPVSGPT GPVVWGEPGT NGQHAFFQLL HQGTDTIPLE
410 420 430 440 450
FIVAAKGHEP TLDHQHEMLM ANCLAQSEAL MKGRTLDEAR AQLQAKNLPA
460 470 480 490 500
SQVERIAPHR VFSGNRPSLT LIHDMLDPYT LGRLIALYEH RVFVEAQIFG
510 520 530 540
INAFDQWGVE LGKELATELL PVVSGKEGAS GRDASTQGLV AHLHARRKA
Length:549
Mass (Da):59,642
Last modified:March 27, 2002 - v1
Checksum:iB2EFDDCE8392C968
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52817.1.
PIRiAF3456.
RefSeqiWP_004682840.1. NZ_GG703778.1.

Genome annotation databases

EnsemblBacteriaiAAL52817; AAL52817; BMEI1636.
KEGGibme:BMEI1636.
bmel:DK63_1855.
PATRICi17796651. VBIBruMel146950_0145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52817.1.
PIRiAF3456.
RefSeqiWP_004682840.1. NZ_GG703778.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4EM6X-ray1.90A/B/C/D1-549[»]
ProteinModelPortaliQ8YF86.
SMRiQ8YF86.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BAWG_0590.

Proteomic databases

PRIDEiQ8YF86.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL52817; AAL52817; BMEI1636.
KEGGibme:BMEI1636.
bmel:DK63_1855.
PATRICi17796651. VBIBruMel146950_0145.

Phylogenomic databases

eggNOGiENOG4107QP8. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000261370.
KOiK01810.
OMAiSHLIAPY.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Miscellaneous databases

PROiQ8YF86.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PI_BRUME
AccessioniPrimary (citable) accession number: Q8YF86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.