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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei353 – 3531Proton donorUniRule annotation
Active sitei384 – 3841UniRule annotation
Active sitei513 – 5131UniRule annotation

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:BMEI1636
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Glucose-6-phosphate isomerasePRO_0000180609Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224914.BMEI1636.

Structurei

Secondary structure

1
549
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 2117Combined sources
Helixi27 – 337Combined sources
Helixi37 – 404Combined sources
Beta strandi42 – 454Combined sources
Beta strandi48 – 514Combined sources
Helixi59 – 7113Combined sources
Helixi74 – 829Combined sources
Turni89 – 924Combined sources
Helixi97 – 1015Combined sources
Helixi116 – 13520Combined sources
Beta strandi136 – 1394Combined sources
Beta strandi148 – 1525Combined sources
Helixi155 – 1573Combined sources
Helixi159 – 1679Combined sources
Helixi169 – 1713Combined sources
Beta strandi174 – 1807Combined sources
Helixi185 – 1928Combined sources
Helixi197 – 1993Combined sources
Beta strandi200 – 2056Combined sources
Beta strandi207 – 2093Combined sources
Helixi212 – 22918Combined sources
Helixi231 – 2366Combined sources
Beta strandi238 – 2414Combined sources
Helixi245 – 2517Combined sources
Helixi255 – 2573Combined sources
Helixi267 – 2693Combined sources
Helixi274 – 2763Combined sources
Helixi277 – 2837Combined sources
Helixi285 – 30420Combined sources
Helixi307 – 3093Combined sources
Helixi311 – 32414Combined sources
Beta strandi330 – 3367Combined sources
Helixi338 – 3403Combined sources
Helixi343 – 35513Combined sources
Beta strandi373 – 3753Combined sources
Helixi381 – 3844Combined sources
Helixi387 – 3926Combined sources
Beta strandi393 – 3953Combined sources
Beta strandi399 – 4068Combined sources
Helixi410 – 4123Combined sources
Helixi413 – 43220Combined sources
Helixi436 – 44510Combined sources
Helixi450 – 4567Combined sources
Helixi457 – 4604Combined sources
Beta strandi468 – 4747Combined sources
Helixi478 – 49922Combined sources
Helixi507 – 5093Combined sources
Helixi510 – 52314Combined sources
Helixi534 – 54714Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EM6X-ray1.90A/B/C/D1-549[»]
ProteinModelPortaliQ8YF86.
SMRiQ8YF86. Positions 13-549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261370.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YF86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARDATKLEA TVAKLKKHWA ESAPRDMRAA FSADPGRFGR YSLCLDDLLF
60 70 80 90 100
DWSKCRVNDE TMALLKELAV AADVEGRRAA MFAGEHINNT EDRAVLHVAL
110 120 130 140 150
RDTSSKEVLV DGHNVLPDVK HVLDRMAAFA DGIRSGALKG ATGRKITDIV
160 170 180 190 200
NIGIGGSDLG PVMATLALAP YHDEPRAHFV SNIDGAHIAD TLSPLDPAST
210 220 230 240 250
LIIVASKTFT TIETMTNAQT ARKWVADTLG EAAVGAHFAA VSTALDKVAA
260 270 280 290 300
FGIPEDRVFG FWDWVGGRYS VWSAIGLPVM IAVGPDNFRK FLAGAHAMDV
310 320 330 340 350
HFRDAPLEKN LPVMLGLIGY WHRAICGYGS RAIIPYDQRL SRLPAYLQQL
360 370 380 390 400
DMESNGKSVT LDGKPVSGPT GPVVWGEPGT NGQHAFFQLL HQGTDTIPLE
410 420 430 440 450
FIVAAKGHEP TLDHQHEMLM ANCLAQSEAL MKGRTLDEAR AQLQAKNLPA
460 470 480 490 500
SQVERIAPHR VFSGNRPSLT LIHDMLDPYT LGRLIALYEH RVFVEAQIFG
510 520 530 540
INAFDQWGVE LGKELATELL PVVSGKEGAS GRDASTQGLV AHLHARRKA
Length:549
Mass (Da):59,642
Last modified:March 27, 2002 - v1
Checksum:iB2EFDDCE8392C968
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52817.1.
PIRiAF3456.
RefSeqiNP_540553.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL52817; AAL52817; BMEI1636.
GeneIDi1197347.
KEGGibme:BMEI1636.
PATRICi17796651. VBIBruMel146950_0145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL52817.1.
PIRiAF3456.
RefSeqiNP_540553.1. NC_003317.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4EM6X-ray1.90A/B/C/D1-549[»]
ProteinModelPortaliQ8YF86.
SMRiQ8YF86. Positions 13-549.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BMEI1636.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL52817; AAL52817; BMEI1636.
GeneIDi1197347.
KEGGibme:BMEI1636.
PATRICi17796651. VBIBruMel146950_0145.

Phylogenomic databases

HOGENOMiHOG000261370.
KOiK01810.
OMAiFELANDC.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiG6PI_BRUME
AccessioniPrimary (citable) accession number: Q8YF86
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 27, 2002
Last modified: January 7, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.