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Q8YEP2

- PNCB_BRUME

UniProt

Q8YEP2 - PNCB_BRUME

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Protein
Nicotinate phosphoribosyltransferase
Gene
pncB, BMEI1836
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate phosphoribosyltransferase activity Source: InterPro
  3. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferase (EC:6.3.4.21)
Short name:
NAPRTase
Gene namesi
Name:pncB
Ordered Locus Names:BMEI1836
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Nicotinate phosphoribosyltransferaseUniRule annotation
PRO_0000205821Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224914.BMEI1836.

Structurei

3D structure databases

ProteinModelPortaliQ8YEP2.
SMRiQ8YEP2. Positions 1-426.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.

Phylogenomic databases

HOGENOMiHOG000284929.
KOiK00763.
OMAiSIVCKVI.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YEP2-1 [UniParc]FASTAAdd to Basket

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MAKTDLARRV YNHTWKLDPI IRSLLDTDFY KLLMLQMIWG LYPRVDATFS    50
LINRTSSVRL ADEIDEGELR AQLDHARTLR FSKKEMIWLA GNTFYGRKQI 100
FQPEFLAWLH DCQLPEYELR RKDGQYELHF HGPWTHTTMW EIPALAIINE 150
LRSRAAMKNL GPFSLDVLYA RAKAKMWSKV ERLRQLPDLK ISDFGTRRRH 200
SFLWQRWCVE ALKEGIGSAF TGTSNVLLAM DTDLEALGTN AHELPMVLAA 250
LAKTDDELRS APYRVLQDWN RYYGGNLLIV LPDAFGTAAF LRNAPDWVAD 300
WTGFRPDSAP PIEGGERIIE WWKSKGKDPR EKLLIFSDAL DVDTIEETYR 350
HFEGRVRMGF GWGTNLTNDF AGCAPQSIDG LKAISLVCKV TDANGHPAVK 400
LSDNPQKATG DPKEVARYLR FFGNEERVEQ LVRV 434
Length:434
Mass (Da):49,865
Last modified:March 1, 2002 - v1
Checksum:i63A902D78DE93490
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL53017.1.
PIRiAF3481.
RefSeqiNP_540753.1. NC_003317.1.

Genome annotation databases

EnsemblBacteriaiAAL53017; AAL53017; BMEI1836.
GeneIDi1197547.
KEGGibme:BMEI1836.
PATRICi17796218. VBIBruMel146950_1382.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008917 Genomic DNA. Translation: AAL53017.1 .
PIRi AF3481.
RefSeqi NP_540753.1. NC_003317.1.

3D structure databases

ProteinModelPortali Q8YEP2.
SMRi Q8YEP2. Positions 1-426.
ModBasei Search...

Protein-protein interaction databases

STRINGi 224914.BMEI1836.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL53017 ; AAL53017 ; BMEI1836 .
GeneIDi 1197547.
KEGGi bme:BMEI1836.
PATRICi 17796218. VBIBruMel146950_1382.

Phylogenomic databases

HOGENOMi HOG000284929.
KOi K00763.
OMAi SIVCKVI.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiPNCB_BRUME
AccessioniPrimary (citable) accession number: Q8YEP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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