Q8YEP2 (PNCB_BRUME) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 72.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Nicotinate phosphoribosyltransferase Short name=NAPRTase EC=2.4.2.11 | ||||
| Gene names |
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| Organism | Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 224914 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › ![]() |
Protein attributes
| Sequence length | 434 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | Beta-nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00570 |
| Pathway | Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570 |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the NAPRTase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Pyridine nucleotide biosynthesis |
| Cellular component | Cytoplasm |
| Molecular function | Glycosyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic processInferred from electronic annotation. Source: InterPro |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP nicotinate-nucleotide diphosphorylase (carboxylating) activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 434 | 434 | Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570 | PRO_0000205821 | |||
Sequences
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References
| [1] | "The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. Overbeek R.Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE008917 Genomic DNA. Translation: AAL53017.1. |
| PIR | AF3481. |
| RefSeq | NP_540753.1. NC_003317.1. |
3D structure databases | |
| ProteinModelPortal | Q8YEP2. |
| SMR | Q8YEP2. Positions 1-426. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 224914.BMEI1836. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | AAL53017; AAL53017; BMEI1836. |
| GeneID | 1197547. |
| KEGG | bme:BMEI1836. |
| PATRIC | 17796218. VBIBruMel146950_1382. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HOG000284929. |
| KO | K00763. |
| OMA | SFGWGTN. |
| ProtClustDB | PRK05321. |
Enzyme and pathway databases | |
| UniPathway | UPA00253; UER00457. |
Family and domain databases | |
| HAMAP | MF_00570. NAPRTase. |
| InterPro | IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. IPR002638. Quinolinate_PRibosylTrfase_C. [Graphical view] |
| PANTHER | PTHR11098:SF1. PTHR11098:SF1. 1 hit. |
| Pfam | PF04095. NAPRTase. 1 hit. [Graphical view] |
| PIRSF | PIRSF000484. NAPRT. 1 hit. |
| SUPFAM | SSF51690. Q_phspho_trans. 1 hit. |
| TIGRFAMs | TIGR01514. NAPRTase. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PNCB_BRUME | ||||||||
| Accession | Primary (citable) accession number: Q8YEP2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Brucella melitensis Brucella melitensis (strain 16M): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
