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Q8YEP2 (PNCB_BRUME) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
Name:pncB
Ordered Locus Names:BMEI1836
OrganismBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]
Taxonomic identifier224914 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity. HAMAP-Rule MF_00570

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. HAMAP-Rule MF_00570

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570
PRO_0000205821

Sequences

Sequence LengthMass (Da)Tools
Q8YEP2 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 63A902D78DE93490

FASTA43449,865
        10         20         30         40         50         60 
MAKTDLARRV YNHTWKLDPI IRSLLDTDFY KLLMLQMIWG LYPRVDATFS LINRTSSVRL 

        70         80         90        100        110        120 
ADEIDEGELR AQLDHARTLR FSKKEMIWLA GNTFYGRKQI FQPEFLAWLH DCQLPEYELR 

       130        140        150        160        170        180 
RKDGQYELHF HGPWTHTTMW EIPALAIINE LRSRAAMKNL GPFSLDVLYA RAKAKMWSKV 

       190        200        210        220        230        240 
ERLRQLPDLK ISDFGTRRRH SFLWQRWCVE ALKEGIGSAF TGTSNVLLAM DTDLEALGTN 

       250        260        270        280        290        300 
AHELPMVLAA LAKTDDELRS APYRVLQDWN RYYGGNLLIV LPDAFGTAAF LRNAPDWVAD 

       310        320        330        340        350        360 
WTGFRPDSAP PIEGGERIIE WWKSKGKDPR EKLLIFSDAL DVDTIEETYR HFEGRVRMGF 

       370        380        390        400        410        420 
GWGTNLTNDF AGCAPQSIDG LKAISLVCKV TDANGHPAVK LSDNPQKATG DPKEVARYLR 

       430 
FFGNEERVEQ LVRV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008917 Genomic DNA. Translation: AAL53017.1.
PIRAF3481.
RefSeqNP_540753.1. NC_003317.1.

3D structure databases

ProteinModelPortalQ8YEP2.
SMRQ8YEP2. Positions 1-426.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224914.BMEI1836.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL53017; AAL53017; BMEI1836.
GeneID1197547.
KEGGbme:BMEI1836.
PATRIC17796218. VBIBruMel146950_1382.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000284929.
KOK00763.
OMAKLTMQCA.
OrthoDBEOG6X10XB.
ProtClustDBPRK05321.

Enzyme and pathway databases

UniPathwayUPA00253; UER00457.

Family and domain databases

HAMAPMF_00570. NAPRTase.
InterProIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERPTHR11098:SF1. PTHR11098:SF1. 1 hit.
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 1 hit.
TIGRFAMsTIGR01514. NAPRTase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNCB_BRUME
AccessionPrimary (citable) accession number: Q8YEP2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: March 1, 2002
Last modified: March 19, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names