Reviewed,
UniProtKB/Swiss-Prot Q8YEK2 (DNAE2_BRUME)
Last modified
February 9, 2010.
Version 53.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Error-prone DNA polymerase EC=2.7.7.7 | ||||
| Gene names |
| ||||
| Organism | Brucella melitensis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 29459 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 1077 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity. HAMAP MF_01902 |
| Catalytic activity | Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902 |
| Subcellular location | Cytoplasm Probable HAMAP MF_01902. |
| Sequence similarities | Belongs to the DNA polymerase type-C family. DnaE2 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA damage DNA repair DNA replication |
| Cellular component | Cytoplasm |
| Molecular function | DNA-directed DNA polymerase Nucleotidyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA repair Inferred from electronic annotation. Source: UniProtKB-KW DNA replicationInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA bindingInferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 1077 | 1077 | Error-prone DNA polymerase HAMAP MF_01902 | PRO_0000103371 | |||
Sequences
| ||||||||||||||||||
References
| [1] | "The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. Overbeek R.Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094 / Biotype 1. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE008917 Genomic DNA. Translation: AAL53057.1. Different initiation. |
| PIR | AF3486. |
| RefSeq | NP_540793.1. |
3D structure databases | |
| SMR | Q8YEK2. Positions 3-886. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1197587. |
| GenomeReviews | Gene locus BMEI1876 in contig AE008917_GR. |
| KEGG | bme:BMEI1876. |
| NMPDR | fig|224914.1.peg.1875. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG734490. |
| OMA | MGFYSPD. |
Enzyme and pathway databases | |
| BioCyc | BMEL224914:BMEI1876-MONOMER. |
| BRENDA | 2.7.7.7. 277959. |
Family and domain databases | |
| HAMAP | MF_01902. DNApol_error_prone. [Tree] |
| InterPro | IPR011708. DNA_pol3_alpha. IPR004365. NA_bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view] |
| Pfam | PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view] |
| SMART | SM00481. POLIIIAc. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00594. polc. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | DNAE2_BRUME | ||||||||
| Accession | Primary (citable) accession number: Q8YEK2 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Brucella melitensis Brucella melitensis (strain 16M): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with


