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Q8YEG1

- AROA_BRUME

UniProt

Q8YEG1 - AROA_BRUME

Protein

3-phosphoshikimate 1-carboxyvinyltransferase

Gene

aroA

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (06 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 3-phosphoshikimate 1-carboxyvinyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-KW
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Enzyme and pathway databases

    BioCyciBMEL224914:GCJ0-1963-MONOMER.
    UniPathwayiUPA00053; UER00089.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-phosphoshikimate 1-carboxyvinyltransferaseUniRule annotation (EC:2.5.1.19UniRule annotation)
    Alternative name(s):
    5-enolpyruvylshikimate-3-phosphate synthaseUniRule annotation
    Short name:
    EPSP synthaseUniRule annotation
    Short name:
    EPSPSUniRule annotation
    Gene namesi
    Name:aroAUniRule annotation
    Ordered Locus Names:BMEI1917
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4504503-phosphoshikimate 1-carboxyvinyltransferasePRO_0000088233Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi224914.BMEI1917.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YEG1.
    SMRiQ8YEG1. Positions 8-447.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the EPSP synthase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000247371.
    KOiK00800.
    OMAiKRPMRRI.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.65.10.10. 2 hits.
    HAMAPiMF_00210. EPSP_synth.
    InterProiIPR001986. Enolpyruvate_Tfrase_dom.
    IPR006264. EPSP_synthase.
    IPR023193. EPSP_synthase_CS.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    [Graphical view]
    PfamiPF00275. EPSP_synthase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000505. EPSPS. 1 hit.
    SUPFAMiSSF55205. SSF55205. 1 hit.
    TIGRFAMsiTIGR01356. aroA. 1 hit.
    PROSITEiPS00104. EPSP_SYNTHASE_1. 1 hit.
    PS00885. EPSP_SYNTHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8YEG1-1 [UniParc]FASTAAdd to Basket

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    MSHSACPKPA TARHSQALTG EIRIPGDKSI SHRSFMFGGL ASGKTRITGL    50
    LEGEDVINTG RAMQAMGARI RKEGDVWIIN GVGNGCLLQP EAPLDFGNAG 100
    TGARLTMGLV GTYDMKTSFI GDASLSKRPM GRVLNPLREM GVQVEAAEGD 150
    RMPLTLIGPR TANPIAYRVP MASAQVKSAV LLAGLNTPGV TTVIEPVMTR 200
    DHTEKMLQGF GADLTVETDK DGVRHIRIVG QGKLTGQTID VPGDPSSTAF 250
    PLVAALLVEG SDVTIRNVLM NPTRTGLILT LQEMGADIEI IDPRLAGGED 300
    VADLRVKASK LKGVVVPPER APSMIDEYPV LAIAASFAEG ETVMDGLDEL 350
    RVKESDRLAA VARGLEANGV DCTEGEMSLT VRGRPGGKGL GGGTVGTHLD 400
    HRIAMSFLVM GLASEKPVTV DDSTMIATSF PEFMGMMAGL GAKIAESGAE 450
    Length:450
    Mass (Da):47,207
    Last modified:June 6, 2003 - v2
    Checksum:i931C4B483C162CB7
    GO

    Sequence cautioni

    The sequence AAL53098.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL53098.1. Different initiation.
    PIRiAG3491.
    RefSeqiNP_540834.1. NC_003317.1.

    Genome annotation databases

    EnsemblBacteriaiAAL53098; AAL53098; BMEI1917.
    GeneIDi1197628.
    KEGGibme:BMEI1917.
    PATRICi17854268. VBIBruMel92729_2119.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008917 Genomic DNA. Translation: AAL53098.1 . Different initiation.
    PIRi AG3491.
    RefSeqi NP_540834.1. NC_003317.1.

    3D structure databases

    ProteinModelPortali Q8YEG1.
    SMRi Q8YEG1. Positions 8-447.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEI1917.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL53098 ; AAL53098 ; BMEI1917 .
    GeneIDi 1197628.
    KEGGi bme:BMEI1917.
    PATRICi 17854268. VBIBruMel92729_2119.

    Phylogenomic databases

    HOGENOMi HOG000247371.
    KOi K00800.
    OMAi KRPMRRI.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00089 .
    BioCyci BMEL224914:GCJ0-1963-MONOMER.

    Family and domain databases

    Gene3Di 3.65.10.10. 2 hits.
    HAMAPi MF_00210. EPSP_synth.
    InterProi IPR001986. Enolpyruvate_Tfrase_dom.
    IPR006264. EPSP_synthase.
    IPR023193. EPSP_synthase_CS.
    IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
    [Graphical view ]
    Pfami PF00275. EPSP_synthase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000505. EPSPS. 1 hit.
    SUPFAMi SSF55205. SSF55205. 1 hit.
    TIGRFAMsi TIGR01356. aroA. 1 hit.
    PROSITEi PS00104. EPSP_SYNTHASE_1. 1 hit.
    PS00885. EPSP_SYNTHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiAROA_BRUME
    AccessioniPrimary (citable) accession number: Q8YEG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2003
    Last sequence update: June 6, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3