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Protein
Submitted name:

Hydroxymethylglutaryl-CoA lyase

Gene

BMEI1926

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi14 – 141CalciumCombined sources
Metal bindingi205 – 2051Calcium; via tele nitrogenCombined sources
Metal bindingi207 – 2071Calcium; via tele nitrogenCombined sources
Metal bindingi247 – 2471CalciumCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

LyaseImported

Keywords - Ligandi

CalciumCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BioCyciBMEL224914:GCJ0-1973-MONOMER.
BRENDAi4.1.3.4. 995.

Names & Taxonomyi

Protein namesi
Submitted name:
Hydroxymethylglutaryl-CoA lyaseImported (EC:4.1.3.4Imported)
Gene namesi
Ordered Locus Names:BMEI1926Imported
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)Imported
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_0314.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YDNX-ray2.30A/B/C/D1-287[»]
SMRiQ8YEF2. Positions 2-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4105CBH. Bacteria.
COG0119. LUCA.
HOGENOMiHOG000219757.
KOiK01640.
OMAiVWQFDTS.
OrthoDBiEOG6JMMRC.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000891. PYR_CT.
[Graphical view]
PfamiPF00682. HMGL-like. 1 hit.
[Graphical view]
PROSITEiPS50991. PYR_CT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YEF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEHVEIVEM AARDGLQNEK RFVPTADKIA LINRLSDCGY ARIEATSFVS
60 70 80 90 100
PKWVPQLADS REVMAGIRRA DGVRYSVLVP NMKGYEAAAA AHADEIAVFI
110 120 130 140 150
SASEGFSKAN INCTIAESIE RLSPVIGAAI NDGLAIRGYV SCVVECPYDG
160 170 180 190 200
PVTPQAVASV TEQLFSLGCH EVSLGDTIGR GTPDTVAAML DAVLAIAPAH
210 220 230 240 250
SLAGHYHDTG GRALDNIRVS LEKGLRVFDA SVGGLGGCPF APGAKGNVDT
260 270 280
VAVVEMLHEM GFETGLDLDR LRSAGLFTQA LRQDKAA
Length:287
Mass (Da):30,253
Last modified:March 1, 2002 - v1
Checksum:i0F0762A723BD9295
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL53107.1.
PIRiAH3492.
RefSeqiWP_004684602.1. NZ_GG703778.1.

Genome annotation databases

EnsemblBacteriaiAAL53107; AAL53107; BMEI1926.
EEW88206; EEW88206; BAWG_0314.
KEGGibme:BMEI1926.
bmel:DK63_1562.
PATRICi17796008. VBIBruMel146950_1275.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008917 Genomic DNA. Translation: AAL53107.1.
PIRiAH3492.
RefSeqiWP_004684602.1. NZ_GG703778.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YDNX-ray2.30A/B/C/D1-287[»]
SMRiQ8YEF2. Positions 2-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BAWG_0314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL53107; AAL53107; BMEI1926.
EEW88206; EEW88206; BAWG_0314.
KEGGibme:BMEI1926.
bmel:DK63_1562.
PATRICi17796008. VBIBruMel146950_1275.

Phylogenomic databases

eggNOGiENOG4105CBH. Bacteria.
COG0119. LUCA.
HOGENOMiHOG000219757.
KOiK01640.
OMAiVWQFDTS.
OrthoDBiEOG6JMMRC.

Enzyme and pathway databases

BioCyciBMEL224914:GCJ0-1973-MONOMER.
BRENDAi4.1.3.4. 995.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000891. PYR_CT.
[Graphical view]
PfamiPF00682. HMGL-like. 1 hit.
[Graphical view]
PROSITEiPS50991. PYR_CT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094Imported.

Entry informationi

Entry nameiQ8YEF2_BRUME
AccessioniPrimary (citable) accession number: Q8YEF2
Secondary accession number(s): D0B482
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.