Q8YDZ2 (VIRB6_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Type IV secretion system protein VirB6

Gene names

Name:	virB6
Ordered Locus Names:	BMEII0030

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella melitensis › Brucella melitensis bv. 1

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Cell inner membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the TrbL/VirB6 family.

Ontologies

Keywords
Biological process	Virulence
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW protein secretion by the type IV secretion system Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	Type IV secretion system protein VirB6		PRO_0000290182
Regions
	Transmembrane	32 – 52	21	Helical; Potential
	Transmembrane	61 – 81	21	Helical; Potential
	Transmembrane	153 – 173	21	Helical; Potential
	Transmembrane	177 – 197	21	Helical; Potential
	Transmembrane	205 – 225	21	Helical; Potential
	Transmembrane	245 – 265	21	Helical; Potential
	Transmembrane	270 – 290	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8YDZ2 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 32ABBB639420053F	FASTA	347	36,175
	10 20 30 40 50 60 MVNPVIFEFI GTSIHNQLNN YVTMVASNTM NMIATTAVLA GGLYYTAMGI LMSVGRIEGP 70 80 90 100 110 120 FSQLVISCIK FMLIAAFALN ISTYSEWVID TVHNMESGFA DAFAGNHGTP SSTIYQTLDN 130 140 150 160 170 180 SLGKGWNIAA MLFEKGDNRG LTQIVQGFSE LLLSFLVAGS TLILAGPTGA MIVATNAVIA 190 200 210 220 230 240 ILLGIGPLFI LALGWAPTRG FFDRWFGTIV TSILQVALLS AVLSISSAIF SRMVAAINLA 250 260 270 280 290 300 SATQSTLFSC LSLTAVTIVM PYMMYKVYEY GGILGSSISA ATISLGSLAV NTAKSGGGAM 310 320 330 340 TSIFSGSSGG GGSGSAKAGG ESSYSAGGNA MWSPAFRQHV LGQFNRD

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008918 Genomic DNA. Translation: AAL53271.1.
PIR	AD3513.
RefSeq	NP_541007.1. NC_003318.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	224914.BMEII0030.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL53271; AAL53271; BMEII0030.
GeneID	1197801.
KEGG	bme:BMEII0030.
PATRIC	17798615. VBIBruMel146950_1651.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000289241.
KO	K03201.
OMA	YQSQVVT.
ProtClustDB	CLSK884265.
Family and domain databases
InterPro	IPR007688. Conjugal_tfr_TrbL/VirB6. [Graphical view]
Pfam	PF04610. TrbL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

VIRB6_BRUME

Accession

Primary (citable) accession number: Q8YDZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 12, 2007
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program