Q8YDS0 (BHUA_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heme transporter BhuA

Gene names

Name:	bhuA
Ordered Locus Names:	BMEII0105

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella melitensis › Brucella melitensis bv. 1

Protein attributes

Sequence length	661 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Heme transporter By similarity.
Subcellular location	Cell outer membrane By similarity.
Induction	Induced in absence of iron By similarity.
Sequence similarities	Belongs to the TonB-dependent receptor family.
Sequence caution	The sequence AAL53346.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Cell outer membrane Membrane
Domain	Signal TonB box Transmembrane Transmembrane beta strand
Molecular function	Receptor
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	cell outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	receptor activity Inferred from electronic annotation. Source: InterPro transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 661	638	Heme transporter BhuA		PRO_0000325858

Sequences

	Sequence		Length	Mass (Da)
	Q8YDS0 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: 05E037EE977894EE	FASTA	661	72,933
	10 20 30 40 50 60 MKFTRMLVLA STSLLATVAT SQAQEVKRDT KKQGEVVLKP ITIISHGKDN IEATGGTVLT 70 80 90 100 110 120 YKDIEKLQPA NVSELFSRQS SIAVSGGGGP SKRIHVLGME QSNLAVSVDG VPQTATSWHH 130 140 150 160 170 180 TGSNVIDPAF LKRVEVEAGA AAADSGFGAA AGAIRYETVN ALDLLEPGKT FGARIIGSYG 190 200 210 220 230 240 TNGRGFSGST AAYGLKDGFD WLLMLHGTSG HNYKNGDGTE ILGTEPAARN ILGKAGYEFD 250 260 270 280 290 300 GNRIDIGYER SRDKADRLIK MNMGLPGDTE YPLEVARDSV NIKYTRTDAT DMWDPEVQFY 310 320 330 340 350 360 YNRNDYWRND YQNRTNGNMI LKEDLYGGKL QNTFTIDYGK ITAGIDFGKH DYNTDNYGHN 370 380 390 400 410 420 DRRYRKFNTQ QVGAFTQGRF EFDNGFSLST GARYDYSRFA DWNDEVFSDS GASVNGTLSY 430 440 450 460 470 480 KFNEHIEVFA GASRTWLGYV LGDYGYVHAR NNAFYTDPTF SPGRARNYKA GVNFGGADWS 490 500 510 520 530 540 AGITLFDTRI AGLPNYDSQK LGNDPEEYRS RGFTLNARYI WNYTTIGATF TKAKVTAGDD 550 560 570 580 590 600 PVLPNSGSFM PIGDMATLFI DQEIPDYNMK VGATLAWAGR ISDEAATAAN FYDQPAYTVV 610 620 630 640 650 660 NAYAEWNPPA VKNMTLRVGV ENLFNENYYE RTSFAPSQNR GGIDAVWAPG RTFTFQTAFK F

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008918 Genomic DNA. Translation: AAL53346.1. Different initiation.
PIR	AG3522.
RefSeq	NP_541082.1. NC_003318.1.
3D structure databases
ProteinModelPortal	Q8YDS0.
ModBase	Search...
Protein-protein interaction databases
STRING	224914.BMEII0105.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL53346; AAL53346; BMEII0105.
GeneID	1197876.
KEGG	bme:BMEII0105.
PATRIC	17854806. VBIBruMel92729_2384.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000143472.
KO	K16087.
ProtClustDB	CLSK898692.
Enzyme and pathway databases
BioCyc	BMEL224914:GCJ0-2213-MONOMER.
Family and domain databases
Gene3D	2.170.130.10. 1 hit. 2.40.170.20. 1 hit.
InterPro	IPR012910. Plug. IPR000531. TonB-dep_rcpt_b-brl. [Graphical view]
Pfam	PF07715. Plug. 1 hit. PF00593. TonB_dep_Rec. 1 hit. [Graphical view]
PROSITE	PS00430. TONB_DEPENDENT_REC_1. False negative. PS01156. TONB_DEPENDENT_REC_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BHUA_BRUME

Accession

Primary (citable) accession number: Q8YDS0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	May 29, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program