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Q8YDM5

- FLIC_BRUME

UniProt

Q8YDM5 - FLIC_BRUME

Protein

Flagellin

Gene

fliC

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella By similarity. The flagellum is required to cause a persistent disease in a murine model of infection.By similarity1 Publication

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. bacterial-type flagellum-dependent cell motility Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Flagellin
    Gene namesi
    Name:fliC
    Ordered Locus Names:BMEII0150
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome II

    Subcellular locationi

    GO - Cellular componenti

    1. bacterial-type flagellum filament Source: InterPro
    2. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Bacterial flagellum, Secreted

    Pathology & Biotechi

    Disruption phenotypei

    A fliC mutant is attenuated in a murine model of infection. As the infection progresses, the number of cfu per spleen from mice infected with the mutant is significantly lower than the number from mice infected with the wild-type.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 282282FlagellinPRO_0000323998Add
    BLAST

    Expressioni

    Inductioni

    Expressed at the onset of the exponential phase (after 4, 8 and 12 hours of culture) but not at later time points.

    Interactioni

    Protein-protein interaction databases

    STRINGi224914.BMEII0150.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YDM5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the bacterial flagellin family.Curated

    Phylogenomic databases

    HOGENOMiHOG000255145.
    KOiK02406.
    OMAiTKQAAYD.
    OrthoDBiEOG622PP4.

    Family and domain databases

    InterProiIPR001492. Flagellin.
    IPR001029. Flagellin_D0/D1.
    [Graphical view]
    PfamiPF00700. Flagellin_C. 1 hit.
    PF00669. Flagellin_N. 1 hit.
    [Graphical view]
    PRINTSiPR00207. FLAGELLIN.

    Sequencei

    Sequence statusi: Complete.

    Q8YDM5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASILTNSSA LTALQTLAST NKSLESTQNR ISTGLRISEA SDNASYWSIA    50
    TSMKSDNKAN SAVQDALGLG AGKVDTAYSA INKIRESVDD IKTKLVSAMG 100
    ASTEDKGKIE TEIKSIVANI NSALSNANYA GSNLLNGPTT DLNVVASYNR 150
    SGNAVAVDKI TVKATDTDAK TMVKDIVDAG FFTSASDDTA IGTALNTVET 200
    ALASLATGAA TLGAAKSQID SQKSFLSGLQ DSIEKGVGTL VDADMNKESA 250
    RLSALQVQQQ LGVQALSIAN SSNQSILSLF RG 282
    Length:282
    Mass (Da):29,069
    Last modified:March 1, 2002 - v1
    Checksum:iDF645A110EC1D4B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008918 Genomic DNA. Translation: AAL53391.1.
    PIRiAD3528.
    RefSeqiNP_541127.1. NC_003318.1.

    Genome annotation databases

    EnsemblBacteriaiAAL53391; AAL53391; BMEII0150.
    GeneIDi1197921.
    KEGGibme:BMEII0150.
    PATRICi17798345. VBIBruMel146950_1519.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008918 Genomic DNA. Translation: AAL53391.1 .
    PIRi AD3528.
    RefSeqi NP_541127.1. NC_003318.1.

    3D structure databases

    ProteinModelPortali Q8YDM5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEII0150.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL53391 ; AAL53391 ; BMEII0150 .
    GeneIDi 1197921.
    KEGGi bme:BMEII0150.
    PATRICi 17798345. VBIBruMel146950_1519.

    Phylogenomic databases

    HOGENOMi HOG000255145.
    KOi K02406.
    OMAi TKQAAYD.
    OrthoDBi EOG622PP4.

    Miscellaneous databases

    PROi Q8YDM5.

    Family and domain databases

    InterProi IPR001492. Flagellin.
    IPR001029. Flagellin_D0/D1.
    [Graphical view ]
    Pfami PF00700. Flagellin_C. 1 hit.
    PF00669. Flagellin_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00207. FLAGELLIN.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.
    2. "The sheathed flagellum of Brucella melitensis is involved in persistence in a murine model of infection."
      Fretin D., Fauconnier A., Koehler S., Halling S., Leonard S., Nijskens C., Ferooz J., Lestrate P., Delrue R.-M., Danese I., Vandenhaute J., Tibor A., DeBolle X., Letesson J.-J.
      Cell. Microbiol. 7:687-698(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN INFECTION PERSISTENCE, EXPRESSION, DISRUPTION PHENOTYPE.
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiFLIC_BRUME
    AccessioniPrimary (citable) accession number: Q8YDM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Despite the presence of a stop codon in position 243 in the fliF gene and in position 127 in the flhA gene, it has been shown that B.melitensis is able to express genes corresponding to the M ring, the hook and the filament of the flagellar apparatus in the early log phase of growth in 2YT broth. Under these conditions, a polar and sheathed flagellar structure is visible by transmission electron microscopy.Curated

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3