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Protein

Flagellar transcriptional regulator FtcR

Gene

ftcR

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for transcription of the fliF gene during vegetative and intracellular growth and for production of the two flagellar components flgE and fliC during vegetative growth. Specifically binds to the fliF promoter region. Could mediate the action of VjbR on flagellar gene expression.1 Publication

Miscellaneous

There is no cognate histidine kinase partner identified so far for FtcR.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi127 – 226OmpR/PhoB-typePROSITE-ProRule annotationAdd BLAST100

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Flagellar transcriptional regulator FtcR
Gene namesi
Name:ftcR
Ordered Locus Names:BMEII0158
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome II

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Disruption phenotypei

Inactivation of the ftcR gene down-regulates the activity of the fliF promoter region and the production of both flgE and fliC proteins during vegetative growth or during macrophage infection. This mutant also lacks the flagellar structures under growth conditions in which the wild-type strain is flagellated. The mutant is not attenuated in cellular infection models but exhibits a marked virulence defect after 4 weeks or more of infection in mice.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003196121 – 227Flagellar transcriptional regulator FtcRAdd BLAST227

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_1319.

Structurei

3D structure databases

ProteinModelPortaliQ8YDL7.
SMRiQ8YDL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 116Response regulatoryPROSITE-ProRule annotationAdd BLAST116

Phylogenomic databases

eggNOGiENOG4106R6A. Bacteria.
ENOG410XRGP. LUCA.
HOGENOMiHOG000226660.
KOiK21603.
OMAiTEIGAMR.

Family and domain databases

CDDicd00156. REC. 1 hit.
cd00383. trans_reg_C. 1 hit.
Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR011006. CheY-like_superfamily.
IPR001867. OmpR/PhoB-type_DNA-bd.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR036388. WH-like_DNA-bd_sf.
PfamiView protein in Pfam
PF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
SMARTiView protein in SMART
SM00862. Trans_reg_C. 1 hit.
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiView protein in PROSITE
PS51755. OMPR_PHOB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YDL7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVVVDDRDM VTEGYSSWFG REGITTTGFT PTDFDEWVES VPEQDIMAIE
60 70 80 90 100
AFLIGECADQ HRLPARIRER CKAPVIAVND RPSLEHTLEL FQSGVDDVVR
110 120 130 140 150
KPVHVREILA RINAIRRRAG ASATSGADGT QLGPIRVFSD GRDPQINGID
160 170 180 190 200
FPLPRRERRI LEYLIANRGR RLNKVQIFSA IYGIFDSEVE ENVVESHISK
210 220
LRKKLRGQLG FDPIDSKRFL GYCINIE
Length:227
Mass (Da):25,738
Last modified:March 1, 2002 - v1
Checksum:i8F95853C781A7748
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008918 Genomic DNA. Translation: AAL53399.1.
PIRiAD3529.
RefSeqiWP_002966643.1. NZ_GG703779.1.

Genome annotation databases

EnsemblBacteriaiAAL53399; AAL53399; BMEII0158.
GeneIDi29595068.
KEGGibme:BMEII0158.
bmel:DK63_3087.
PATRICifig|224914.52.peg.3231.

Similar proteinsi

Entry informationi

Entry nameiFTCR_BRUME
AccessioniPrimary (citable) accession number: Q8YDL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2002
Last modified: October 25, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Lacks the conserved Asp residue in position 50 usually required for phosphorylation. The Glu residue in position 50 may mimic constitutive phosphorylation and allow FtcR to bypass the requirement for phosphorylation.Curated

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names