Q8YDJ7 (ZNUA_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
High-affinity zinc uptake system protein ZnuA

Gene names

Name:	znuA
Ordered Locus Names:	BMEII0178

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella melitensis › Brucella melitensis bv. 1

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Involved in the high-affinity zinc uptake transport system. Required for survival and normal growth under low Zn (2+) concentrations. Also required for virulence and intracellular growth in host cells By similarity.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the bacterial solute-binding protein 9 family.
Sequence caution	The sequence AAL53419.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ion transport Transport Virulence Zinc transport
Cellular component	Periplasm
Domain	Signal
Ligand	Metal-binding Zinc
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW zinc ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 334	311	High-affinity zinc uptake system protein ZnuA		PRO_0000248945
Regions
	Compositional bias	126 – 168	43	His-rich
Sites
	Metal binding	61	1	Zinc By similarity
	Metal binding	168	1	Zinc By similarity
	Metal binding	232	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8YDJ7 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: F3CAA3631569099F	FASTA	334	36,036
	10 20 30 40 50 60 MKNLHSLFLA SAFLAGFCGS SLAGEREGVV VSIKPLHSIV SAVMQGVGKP KLIVQGAGSE 70 80 90 100 110 120 HVYSLKPSDA EAIEHAKVIF WAGPSMETFL DKPIDTLGEG AKVVALGDAK GLTKLKFREG 130 140 150 160 170 180 GPFEAHDHGH GGSHEEEHDA HGSGDHDHAA EVAEEGHEHH HHGEYDLHFW LDPQNGKILA 190 200 210 220 230 240 ADIAKTLGES DPEHAAQYEK NAKAYGEKLD ALTREVAAEL KPVKDKPFIV FHDAYQYFEN 250 260 270 280 290 300 RFGMKAAGSI TVSPEKAPGA ARIQQIHDKI KSLGATCVFS EPQFEPKLVK TVVDGTKART 310 320 330 GVLDPLGAEL KDGPDLYPQL IRNLANSLKD CLSK

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008918 Genomic DNA. Translation: AAL53419.1. Different initiation.
PIR	AH3531.
RefSeq	NP_541155.1. NC_003318.1.
3D structure databases
ProteinModelPortal	Q8YDJ7.
ModBase	Search...
Protein-protein interaction databases
STRING	224914.BMEII0178.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL53419; AAL53419; BMEII0178.
GeneID	1197949.
KEGG	bme:BMEII0178.
PATRIC	17854962. VBIBruMel92729_2461.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000180311.
KO	K09815.
OMA	VQDLPGM.
ProtClustDB	CLSK886373.
Family and domain databases
InterPro	IPR006127. Perip_solute-bd_prot_fam. [Graphical view]
Pfam	PF01297. SBP_bac_9. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ZNUA_BRUME

Accession

Primary (citable) accession number: Q8YDJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	September 5, 2006
Last modified:	May 1, 2013
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program