Q8YDE7 (MSRA_BRUME) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 60.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Peptide methionine sulfoxide reductase MsrA Short name=Protein-methionine-S-oxide reductase EC=1.8.4.11 Alternative name(s): Peptide-methionine (S)-S-oxide reductase Short name=Peptide Met(O) reductase | ||||
| Gene names |
| ||||
| Organism | Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 224914 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 218 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401 |
| Catalytic activity | Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 |
| Sequence similarities | Belongs to the MsrA Met sulfoxide reductase family. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | protein metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 218 | 218 | Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401 | PRO_0000138532 | |||||
Sites | |||||||||
| Active site | 57 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. Overbeek R.Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE008918 Genomic DNA. Translation: AAL53471.1. |
| PIR | AD3538. |
| RefSeq | NP_541207.1. NC_003318.1. |
3D structure databases | |
| ProteinModelPortal | Q8YDE7. |
| SMR | Q8YDE7. Positions 15-213. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1198001. |
| GenomeReviews | Gene locus BMEII0230 in contig AE008918_GR. |
| KEGG | bme:BMEII0230. |
| NMPDR | fig|224914.1.peg.2289. |
| PATRIC | 17800731. VBIBruMel146950_2695. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG748152. |
| OMA | QETSFEQ. |
| PhylomeDB | Q8YDE7. |
| ProtClustDB | PRK00058. |
Enzyme and pathway databases | |
| BioCyc | BMEL224914:BMEII0230-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01401. MsrA. [Tree] |
| InterPro | IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view] |
| Gene3D | G3DSA:3.30.1060.10. MsrA. 1 hit. |
| KO | K07304. |
| Pfam | PF01625. PMSR. 1 hit. [Graphical view] |
| SUPFAM | SSF55068. MsrA. 1 hit. |
| TIGRFAMs | TIGR00401. MsrA. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | MSRA_BRUME | ||||||||
| Accession | Primary (citable) accession number: Q8YDE7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| Brucella melitensis Brucella melitensis (strain 16M): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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