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Reviewed, UniProtKB/Swiss-Prot Q8YDE7 (MSRA_BRUME)

Last modified February 9, 2010. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Peptide methionine sulfoxide reductase msrA
      Short name=Protein-methionine-S-oxide reductase
    EC=1.8.4.11
Alternative name(s):
    Peptide-methionine (S)-S-oxide reductase
      Short name=Peptide Met(O) reductase
Gene names
Name: msrA
Ordered Locus Names: BMEII0230
OrganismBrucella melitensis [Complete proteome] [HAMAP]
Taxonomic identifier29459 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401

Catalytic activity

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401

L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401

Sequence similarities

Belongs to the msrA Met sulfoxide reductase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 218218Peptide methionine sulfoxide reductase msrA HAMAP MF_01401
PRO_0000138532

Sites

Active site571 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8YDE7-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 94B42010667417AD

FASTA21824,047
        10         20         30         40         50         60 
MSFFDSYRKK MQMPSKEEVL PGRVQPIPTA AAHFVSGHPL KGPWPDGMKQ VLFGMGCFWG 

        70         80         90        100        110        120 
AERLFWQVPG VYVTAVGYAG GITPNPTYEE TCTGLTGHAE VVLVVYDPKV VTLNELLALF 

       130        140        150        160        170        180 
WEEHDPTQGM RQGNDIGTTY RSVIYTFNAV DRAVAEKSRD AYSQALASRG LGPVTTQITD 

       190        200        210 
APDFYYAEDY HQQYLAKNPD GYCGLRGTGV SCPIPLAH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008918 Genomic DNA. Translation: AAL53471.1.
PIRAD3538.
RefSeqNP_541207.1.

3D structure databases

SMRQ8YDE7. Positions 15-213.
ModBaseSearch...

Genome annotation databases

GeneID1198001.
GenomeReviewsGene locus BMEII0230 in contig AE008918_GR.
KEGGbme:BMEII0230.
NMPDRfig|224914.1.peg.2289.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG748152.
OMAQETSFEQ.
PhylomeDBQ8YDE7.

Enzyme and pathway databases

BioCycBMEL224914:BMEII0230-MONOMER.
BRENDA1.8.4.11. 277959.

Family and domain databases

HAMAPMF_01401. MsrA.
[Tree]
InterProIPR002569. Peptide_Met_Sox_Rdtase_MsrA.
[Graphical view]
Gene3DG3DSA:3.30.1060.10. MsrA. 1 hit.
PfamPF01625. PMSR. 1 hit.
[Graphical view]
TIGRFAMsTIGR00401. msrA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMSRA_BRUME
AccessionPrimary (citable) accession number: Q8YDE7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 1, 2002
Last modified: February 9, 2010
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents