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Protein

Glucokinase

Gene

glk

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-glucose = ADP + D-glucose 6-phosphate.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 23ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GlucokinaseUniRule annotation (EC:2.7.1.2UniRule annotation)
Alternative name(s):
Glucose kinaseUniRule annotation
Gene namesi
Name:glkUniRule annotation
Ordered Locus Names:BMEII0251
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome II

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002151211 – 343GlucokinaseAdd BLAST343

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_2306.

Structurei

3D structure databases

ProteinModelPortaliQ8YDC6.
SMRiQ8YDC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the bacterial glucokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHC. Bacteria.
COG0837. LUCA.
HOGENOMiHOG000274469.
KOiK00845.
OMAiGHADFAP.

Family and domain databases

HAMAPiMF_00524. Glucokinase. 1 hit.
InterProiView protein in InterPro
IPR003836. Glucokinase.
PfamiView protein in Pfam
PF02685. Glucokinase. 1 hit.
TIGRFAMsiTIGR00749. glk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YDC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQAIIDAEQS FKFPVLVGDI GGTNARFSIL VDSNAEPKEF PVLQTADYAT
60 70 80 90 100
IDEAIQHAIL DQTAIQPRSV ILAVAGPVDG DEIDLTNCDW VVRPKKMIAD
110 120 130 140 150
LGFEDVTVLN DFEAQALAVV SLEGHHMEQI GGKPEEAVAT RVVLGPGTGL
160 170 180 190 200
GVAGLVCTRH AWVPVPGEGG HIDIGPRTER DYQIFPHIER IEGRVTGEQI
210 220 230 240 250
LSGRGLRNLY LGICAADKIT PTLETPVDIT SAGLDGSNPQ AAETLDLFAT
260 270 280 290 300
YLGRLAGDLA LIFMAHGGVY LSGGIPVRIL SALKAGSFRA AFEDKAPNKA
310 320 330 340
IMRDIPVRVI TYQLAALTGL SAFARTPSRF EVSTEGRRWR MRR
Length:343
Mass (Da):36,919
Last modified:June 6, 2002 - v2
Checksum:i8984E115FE71B9EE
GO

Sequence cautioni

The sequence AAL53492 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008918 Genomic DNA. Translation: AAL53492.1. Different initiation.
PIRiAI3540.
RefSeqiWP_004682470.1. NZ_GG703779.1.

Genome annotation databases

EnsemblBacteriaiAAL53492; AAL53492; BMEII0251.
GeneIDi29595726.
KEGGibme:BMEII0251.
bmel:DK63_2990.
PATRICi17800683. VBIBruMel146950_2672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008918 Genomic DNA. Translation: AAL53492.1. Different initiation.
PIRiAI3540.
RefSeqiWP_004682470.1. NZ_GG703779.1.

3D structure databases

ProteinModelPortaliQ8YDC6.
SMRiQ8YDC6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BAWG_2306.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL53492; AAL53492; BMEII0251.
GeneIDi29595726.
KEGGibme:BMEII0251.
bmel:DK63_2990.
PATRICi17800683. VBIBruMel146950_2672.

Phylogenomic databases

eggNOGiENOG4105CHC. Bacteria.
COG0837. LUCA.
HOGENOMiHOG000274469.
KOiK00845.
OMAiGHADFAP.

Family and domain databases

HAMAPiMF_00524. Glucokinase. 1 hit.
InterProiView protein in InterPro
IPR003836. Glucokinase.
PfamiView protein in Pfam
PF02685. Glucokinase. 1 hit.
TIGRFAMsiTIGR00749. glk. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLK_BRUME
AccessioniPrimary (citable) accession number: Q8YDC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 6, 2002
Last modified: February 15, 2017
This is version 78 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.