Q8YDA3 (YIDC_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Membrane protein insertase YidC

Alternative name(s):
Foldase YidC
Membrane integrase YidC
Membrane protein YidC

Gene names

Name:	yidC
Ordered Locus Names:	BMEII0275

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella melitensis › Brucella melitensis bv. 1

Protein attributes

Sequence length	610 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins By similarity. HAMAP-Rule MF_01810
Subunit structure	Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01810.
Sequence similarities	Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
Sequence caution	The sequence AAL53516.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Chaperone
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein insertion into membrane Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 610	610	Membrane protein insertase YidC HAMAP-Rule MF_01810		PRO_0000124694
Regions
	Transmembrane	7 – 27	21	Helical; Potential
	Transmembrane	358 – 378	21	Helical; Potential
	Transmembrane	387 – 407	21	Helical; Potential
	Transmembrane	458 – 478	21	Helical; Potential
	Transmembrane	510 – 530	21	Helical; Potential
	Transmembrane	546 – 566	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8YDA3 [UniParc]. Last modified November 21, 2003. Version 2. Checksum: FB13B7D1B5C1652D	FASTA	610	69,051
	10 20 30 40 50 60 MENKRNFFIT IALSILILAL WQVFYLGPKT EAQREQARIE EQQRQAQQAA QNRQASSSTG 70 80 90 100 110 120 DTPQMPANPD SIPGQGDTKA AGAPLTRDAA IAQSPRIEID TPSLRGSINL TGARLDDLYL 130 140 150 160 170 180 KKYHETVSDK SPEIELLAPS SLKQGYFVEL GFTGNDATGA VPGPNTVWVV EGNNKLTPST 190 200 210 220 230 240 PVTLTYTNDK NLTFKRVISV DDAYMFTVDD TIINNGGSTV SLASYGRVTR FNQPEHASAT 250 260 270 280 290 300 YVLHEGLIGV MGQDGLQEIK YAKIEDNKDI SFKDVIGGWV GITDKYWAAT LIPPQDEKFT 310 320 330 340 350 360 GRFSHFTNDR PRYQSDLLSA PLTVAPGQSQ KIQNRVFAGA KVVNTIQNYE TKYHIKQFDL 370 380 390 400 410 420 LIDWGWFYFI TKPMFYLIDW IYKFTGNFGV AILVVTVLLK ALFFPLANKS YKSMARMKLM 430 440 450 460 470 480 QPKMTEIREK YADDKMKQQQ AMMELYKREK INPLAGCWPV LVQIPVFFAL YKVLYVTIEM 490 500 510 520 530 540 RHAPFFGWIQ DLAAPDPTSI FNLFGLLPYT VPHFLMIGVW PIIMGIIMFL QMRMNPTPPD 550 560 570 580 590 600 PTQAAIFTWM PIIFTFMLAS FPAGLVIYWA WNNTLSIIQQ SVIMKRQGVK IELFDNLKGL 610 FRRKPKEANK

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008918 Genomic DNA. Translation: AAL53516.1. Different initiation.
PIR	AI3543.
RefSeq	NP_541252.2. NC_003318.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	224914.BMEII0275.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL53516; AAL53516; BMEII0275.
GeneID	1198046.
KEGG	bme:BMEII0275.
PATRIC	17855188. VBIBruMel92729_2565.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000101821.
KO	K03217.
OMA	FVTIEMR.
ProtClustDB	PRK01318.
Family and domain databases
HAMAP	MF_01810. YidC_type1.
InterPro	IPR019998. Membr_insert_YidC. IPR001708. Membrane_insert_OXA1/ALB3/YidC. [Graphical view]
PANTHER	PTHR12428. PTHR12428. 1 hit.
Pfam	PF02096. 60KD_IMP. 1 hit. [Graphical view]
PRINTS	PR00701. 60KDINNERMP. PR01900. YIDCPROTEIN.
TIGRFAMs	TIGR03593. yidC_nterm. 1 hit. TIGR03592. yidC_oxa1_cterm. 1 hit.
ProtoNet	Search...

Entry information

Entry name

YIDC_BRUME

Accession

Primary (citable) accession number: Q8YDA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	November 21, 2003
Last modified:	May 1, 2013
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program