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Protein

Membrane protein insertase YidC

Gene

yidC

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.UniRule annotation

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciBMEL224914:G1FZL-2480-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein insertase YidCUniRule annotation
Alternative name(s):
Foldase YidCUniRule annotation
Membrane integrase YidCUniRule annotation
Membrane protein YidCUniRule annotation
Gene namesi
Name:yidCUniRule annotation
Ordered Locus Names:BMEII0275
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome II

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalUniRule annotationAdd BLAST21
Transmembranei358 – 378HelicalUniRule annotationAdd BLAST21
Transmembranei387 – 407HelicalUniRule annotationAdd BLAST21
Transmembranei458 – 478HelicalUniRule annotationAdd BLAST21
Transmembranei510 – 530HelicalUniRule annotationAdd BLAST21
Transmembranei546 – 566HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001246941 – 610Membrane protein insertase YidCAdd BLAST610

Interactioni

Subunit structurei

Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BAWG_2283

Family & Domainsi

Sequence similaritiesi

Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DHW Bacteria
COG0706 LUCA
HOGENOMiHOG000101821
KOiK03217
OMAiINPVAGC

Family and domain databases

Gene3Di2.70.98.90, 1 hit
HAMAPiMF_01810 YidC_type1, 1 hit
InterProiView protein in InterPro
IPR019998 Membr_insert_YidC
IPR028055 Membr_insert_YidC/Oxa1_C
IPR028053 Membr_insert_YidC_N
IPR001708 YidC/ALB3/OXA1/COX18
IPR038210 YidC_periplasmic
IPR038221 YidC_periplasmic_sf
PANTHERiPTHR12428 PTHR12428, 1 hit
PfamiView protein in Pfam
PF02096 60KD_IMP, 1 hit
PF14849 YidC_periplas, 1 hit
PRINTSiPR00701 60KDINNERMP
PR01900 YIDCPROTEIN
TIGRFAMsiTIGR03593 yidC_nterm, 1 hit
TIGR03592 yidC_oxa1_cterm, 1 hit

Sequencei

Sequence statusi: Complete.

Q8YDA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENKRNFFIT IALSILILAL WQVFYLGPKT EAQREQARIE EQQRQAQQAA
60 70 80 90 100
QNRQASSSTG DTPQMPANPD SIPGQGDTKA AGAPLTRDAA IAQSPRIEID
110 120 130 140 150
TPSLRGSINL TGARLDDLYL KKYHETVSDK SPEIELLAPS SLKQGYFVEL
160 170 180 190 200
GFTGNDATGA VPGPNTVWVV EGNNKLTPST PVTLTYTNDK NLTFKRVISV
210 220 230 240 250
DDAYMFTVDD TIINNGGSTV SLASYGRVTR FNQPEHASAT YVLHEGLIGV
260 270 280 290 300
MGQDGLQEIK YAKIEDNKDI SFKDVIGGWV GITDKYWAAT LIPPQDEKFT
310 320 330 340 350
GRFSHFTNDR PRYQSDLLSA PLTVAPGQSQ KIQNRVFAGA KVVNTIQNYE
360 370 380 390 400
TKYHIKQFDL LIDWGWFYFI TKPMFYLIDW IYKFTGNFGV AILVVTVLLK
410 420 430 440 450
ALFFPLANKS YKSMARMKLM QPKMTEIREK YADDKMKQQQ AMMELYKREK
460 470 480 490 500
INPLAGCWPV LVQIPVFFAL YKVLYVTIEM RHAPFFGWIQ DLAAPDPTSI
510 520 530 540 550
FNLFGLLPYT VPHFLMIGVW PIIMGIIMFL QMRMNPTPPD PTQAAIFTWM
560 570 580 590 600
PIIFTFMLAS FPAGLVIYWA WNNTLSIIQQ SVIMKRQGVK IELFDNLKGL
610
FRRKPKEANK
Length:610
Mass (Da):69,051
Last modified:November 21, 2003 - v2
Checksum:iFB13B7D1B5C1652D
GO

Sequence cautioni

The sequence AAL53516 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008918 Genomic DNA Translation: AAL53516.1 Different initiation.
PIRiAI3543
RefSeqiWP_004682443.1, NZ_GG703779.1

Genome annotation databases

EnsemblBacteriaiAAL53516; AAL53516; BMEII0275
GeneIDi29596016
KEGGibme:BMEII0275
bmel:DK63_2967
PATRICifig|224914.52.peg.3113

Similar proteinsi

Entry informationi

Entry nameiYIDC_BRUME
AccessioniPrimary (citable) accession number: Q8YDA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: April 25, 2018
This is version 81 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health