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Q8YDA3 (YIDC_BRUME) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Membrane protein insertase YidC
Alternative name(s):
Foldase YidC
Membrane integrase YidC
Membrane protein YidC
Gene names
Name:yidC
Ordered Locus Names:BMEII0275
OrganismBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]
Taxonomic identifier224914 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length610 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins By similarity. HAMAP-Rule MF_01810

Subunit structure

Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01810.

Sequence similarities

Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.

Sequence caution

The sequence AAL53516.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionChaperone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein insertion into membrane

Inferred from electronic annotation. Source: InterPro

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 610610Membrane protein insertase YidC HAMAP-Rule MF_01810
PRO_0000124694

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane358 – 37821Helical; Potential
Transmembrane387 – 40721Helical; Potential
Transmembrane458 – 47821Helical; Potential
Transmembrane510 – 53021Helical; Potential
Transmembrane546 – 56621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q8YDA3 [UniParc].

Last modified November 21, 2003. Version 2.
Checksum: FB13B7D1B5C1652D

FASTA61069,051
        10         20         30         40         50         60 
MENKRNFFIT IALSILILAL WQVFYLGPKT EAQREQARIE EQQRQAQQAA QNRQASSSTG 

        70         80         90        100        110        120 
DTPQMPANPD SIPGQGDTKA AGAPLTRDAA IAQSPRIEID TPSLRGSINL TGARLDDLYL 

       130        140        150        160        170        180 
KKYHETVSDK SPEIELLAPS SLKQGYFVEL GFTGNDATGA VPGPNTVWVV EGNNKLTPST 

       190        200        210        220        230        240 
PVTLTYTNDK NLTFKRVISV DDAYMFTVDD TIINNGGSTV SLASYGRVTR FNQPEHASAT 

       250        260        270        280        290        300 
YVLHEGLIGV MGQDGLQEIK YAKIEDNKDI SFKDVIGGWV GITDKYWAAT LIPPQDEKFT 

       310        320        330        340        350        360 
GRFSHFTNDR PRYQSDLLSA PLTVAPGQSQ KIQNRVFAGA KVVNTIQNYE TKYHIKQFDL 

       370        380        390        400        410        420 
LIDWGWFYFI TKPMFYLIDW IYKFTGNFGV AILVVTVLLK ALFFPLANKS YKSMARMKLM 

       430        440        450        460        470        480 
QPKMTEIREK YADDKMKQQQ AMMELYKREK INPLAGCWPV LVQIPVFFAL YKVLYVTIEM 

       490        500        510        520        530        540 
RHAPFFGWIQ DLAAPDPTSI FNLFGLLPYT VPHFLMIGVW PIIMGIIMFL QMRMNPTPPD 

       550        560        570        580        590        600 
PTQAAIFTWM PIIFTFMLAS FPAGLVIYWA WNNTLSIIQQ SVIMKRQGVK IELFDNLKGL 

       610 
FRRKPKEANK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008918 Genomic DNA. Translation: AAL53516.1. Different initiation.
PIRAI3543.
RefSeqNP_541252.2. NC_003318.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224914.BMEII0275.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL53516; AAL53516; BMEII0275.
GeneID1198046.
KEGGbme:BMEII0275.
PATRIC17855188. VBIBruMel92729_2565.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000101821.
KOK03217.
OMAFVTIEMR.
OrthoDBEOG6X6RF2.

Family and domain databases

HAMAPMF_01810. YidC_type1.
InterProIPR019998. Membr_insert_YidC.
IPR028055. Membr_insert_YidC/Oxa1_C.
IPR028053. Membr_insert_YidC_N.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERPTHR12428. PTHR12428. 1 hit.
PfamPF02096. 60KD_IMP. 1 hit.
PF14849. YidC_periplas. 1 hit.
[Graphical view]
PRINTSPR00701. 60KDINNERMP.
PR01900. YIDCPROTEIN.
TIGRFAMsTIGR03593. yidC_nterm. 1 hit.
TIGR03592. yidC_oxa1_cterm. 1 hit.
ProtoNetSearch...

Entry information

Entry nameYIDC_BRUME
AccessionPrimary (citable) accession number: Q8YDA3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: May 14, 2014
This is version 66 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names