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Protein

Membrane protein insertase YidC

Gene

yidC

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.UniRule annotation

GO - Biological processi

  1. protein insertion into membrane Source: InterPro
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane protein insertase YidCUniRule annotation
Alternative name(s):
Foldase YidCUniRule annotation
Membrane integrase YidCUniRule annotation
Membrane protein YidCUniRule annotation
Gene namesi
Name:yidCUniRule annotation
Ordered Locus Names:BMEII0275
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419 Componenti: Chromosome II

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalUniRule annotationAdd
BLAST
Transmembranei358 – 37821HelicalUniRule annotationAdd
BLAST
Transmembranei387 – 40721HelicalUniRule annotationAdd
BLAST
Transmembranei458 – 47821HelicalUniRule annotationAdd
BLAST
Transmembranei510 – 53021HelicalUniRule annotationAdd
BLAST
Transmembranei546 – 56621HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 610610Membrane protein insertase YidCPRO_0000124694Add
BLAST

Interactioni

Subunit structurei

Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEII0275.

Family & Domainsi

Sequence similaritiesi

Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000101821.
KOiK03217.
OMAiINPVAGC.
OrthoDBiEOG6X6RF2.

Family and domain databases

HAMAPiMF_01810. YidC_type1.
InterProiIPR019998. Membr_insert_YidC.
IPR028055. Membr_insert_YidC/Oxa1_C.
IPR028053. Membr_insert_YidC_N.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 1 hit.
PfamiPF02096. 60KD_IMP. 1 hit.
PF14849. YidC_periplas. 1 hit.
[Graphical view]
PRINTSiPR00701. 60KDINNERMP.
PR01900. YIDCPROTEIN.
TIGRFAMsiTIGR03593. yidC_nterm. 1 hit.
TIGR03592. yidC_oxa1_cterm. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YDA3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENKRNFFIT IALSILILAL WQVFYLGPKT EAQREQARIE EQQRQAQQAA
60 70 80 90 100
QNRQASSSTG DTPQMPANPD SIPGQGDTKA AGAPLTRDAA IAQSPRIEID
110 120 130 140 150
TPSLRGSINL TGARLDDLYL KKYHETVSDK SPEIELLAPS SLKQGYFVEL
160 170 180 190 200
GFTGNDATGA VPGPNTVWVV EGNNKLTPST PVTLTYTNDK NLTFKRVISV
210 220 230 240 250
DDAYMFTVDD TIINNGGSTV SLASYGRVTR FNQPEHASAT YVLHEGLIGV
260 270 280 290 300
MGQDGLQEIK YAKIEDNKDI SFKDVIGGWV GITDKYWAAT LIPPQDEKFT
310 320 330 340 350
GRFSHFTNDR PRYQSDLLSA PLTVAPGQSQ KIQNRVFAGA KVVNTIQNYE
360 370 380 390 400
TKYHIKQFDL LIDWGWFYFI TKPMFYLIDW IYKFTGNFGV AILVVTVLLK
410 420 430 440 450
ALFFPLANKS YKSMARMKLM QPKMTEIREK YADDKMKQQQ AMMELYKREK
460 470 480 490 500
INPLAGCWPV LVQIPVFFAL YKVLYVTIEM RHAPFFGWIQ DLAAPDPTSI
510 520 530 540 550
FNLFGLLPYT VPHFLMIGVW PIIMGIIMFL QMRMNPTPPD PTQAAIFTWM
560 570 580 590 600
PIIFTFMLAS FPAGLVIYWA WNNTLSIIQQ SVIMKRQGVK IELFDNLKGL
610
FRRKPKEANK
Length:610
Mass (Da):69,051
Last modified:November 20, 2003 - v2
Checksum:iFB13B7D1B5C1652D
GO

Sequence cautioni

The sequence AAL53516.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008918 Genomic DNA. Translation: AAL53516.1. Different initiation.
PIRiAI3543.
RefSeqiNP_541252.2. NC_003318.1.

Genome annotation databases

EnsemblBacteriaiAAL53516; AAL53516; BMEII0275.
KEGGibme:BMEII0275.
PATRICi17855188. VBIBruMel92729_2565.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008918 Genomic DNA. Translation: AAL53516.1. Different initiation.
PIRiAI3543.
RefSeqiNP_541252.2. NC_003318.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BMEII0275.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL53516; AAL53516; BMEII0275.
KEGGibme:BMEII0275.
PATRICi17855188. VBIBruMel92729_2565.

Phylogenomic databases

HOGENOMiHOG000101821.
KOiK03217.
OMAiINPVAGC.
OrthoDBiEOG6X6RF2.

Family and domain databases

HAMAPiMF_01810. YidC_type1.
InterProiIPR019998. Membr_insert_YidC.
IPR028055. Membr_insert_YidC/Oxa1_C.
IPR028053. Membr_insert_YidC_N.
IPR001708. Membrane_insert_OXA1/ALB3/YidC.
[Graphical view]
PANTHERiPTHR12428. PTHR12428. 1 hit.
PfamiPF02096. 60KD_IMP. 1 hit.
PF14849. YidC_periplas. 1 hit.
[Graphical view]
PRINTSiPR00701. 60KDINNERMP.
PR01900. YIDCPROTEIN.
TIGRFAMsiTIGR03593. yidC_nterm. 1 hit.
TIGR03592. yidC_oxa1_cterm. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiYIDC_BRUME
AccessioniPrimary (citable) accession number: Q8YDA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 20, 2003
Last sequence update: November 20, 2003
Last modified: March 31, 2015
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.