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Protein

Methionine import ATP-binding protein MetN

Gene

metN

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi63 – 708ATPUniRule annotation

GO - Molecular functioni

  1. amino acid-transporting ATPase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. methionine transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBMEL224914:GCJ0-2456-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine import ATP-binding protein MetNUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:metNUniRule annotation
Ordered Locus Names:BMEII0337
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419 Componenti: Chromosome II

Subcellular locationi

  1. Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

  1. ATP-binding cassette (ABC) transporter complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Methionine import ATP-binding protein MetNPRO_0000270259Add
BLAST

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (MetN), two transmembrane proteins (MetI) and a solute-binding protein (MetQ).UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEII0337.

Structurei

3D structure databases

ProteinModelPortaliQ8YD40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 266236ABC transporterUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Methionine importer (TC 3.A.1.24) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

KOiK02071.
OMAiYIGHRAL.
OrthoDBiEOG6T7N3V.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR026253. ABC_MetN.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017908. ABC_transprt_methionine_MetN_C.
IPR018449. NIL_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24220:SF186. PTHR24220:SF186. 1 hit.
PfamiPF00005. ABC_tran. 1 hit.
PF09383. NIL. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00930. NIL. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51264. METN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YD40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHAAVCSGT SRHRRTTVTI EKPPATSAPI VEMKDVRRMF GETAAINGVS
60 70 80 90 100
LSVARGEILG IIGRSGAGKS TLIRCVNGLE KPDTGSIHIE GREITSLDED
110 120 130 140 150
ALRPVRRRIG MVFQHFNLLS AKTAAQNIAL PLKIAGMPKA ERIKRVAELL
160 170 180 190 200
ELVGLSDKAS HYPAQLSGGQ KQRVGIARAL AAEPAVLLSD EATSALDPET
210 220 230 240 250
TQSILALLKD INAKLGLTIL LITHEMDVIR RIADRVIVLD HGLIAEEGPV
260 270 280 290 300
WKVFANPQSP VTQSMLQVLT PELPAIWRNR LEKKGDQAIL RVKLSGMAAK
310 320 330 340 350
GAFFNDVAAA TSLAPQLIHG GMDTIQGEPV GTLFIGLPAE DKTKLKAAIG
360
YLNTHADATE VLGYVSGNA
Length:369
Mass (Da):39,445
Last modified:March 1, 2002 - v1
Checksum:i0E42048280DB72DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008918 Genomic DNA. Translation: AAL53579.1.
PIRiAH3551.
RefSeqiNP_541315.1. NC_003318.1.

Genome annotation databases

EnsemblBacteriaiAAL53579; AAL53579; BMEII0337.
KEGGibme:BMEII0337.
PATRICi17855329. VBIBruMel92729_2633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008918 Genomic DNA. Translation: AAL53579.1.
PIRiAH3551.
RefSeqiNP_541315.1. NC_003318.1.

3D structure databases

ProteinModelPortaliQ8YD40.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BMEII0337.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL53579; AAL53579; BMEII0337.
KEGGibme:BMEII0337.
PATRICi17855329. VBIBruMel92729_2633.

Phylogenomic databases

KOiK02071.
OMAiYIGHRAL.
OrthoDBiEOG6T7N3V.

Enzyme and pathway databases

BioCyciBMEL224914:GCJ0-2456-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR026253. ABC_MetN.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017908. ABC_transprt_methionine_MetN_C.
IPR018449. NIL_domain.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24220:SF186. PTHR24220:SF186. 1 hit.
PfamiPF00005. ABC_tran. 1 hit.
PF09383. NIL. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00930. NIL. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51264. METN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiMETN_BRUME
AccessioniPrimary (citable) accession number: Q8YD40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 1, 2002
Last modified: April 29, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.