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Protein

Nickel import ATP-binding protein NikD

Gene

nikD

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system.UniRule annotation

Catalytic activityi

ATP + H2O + Ni2+(Out) = ADP + phosphate + Ni2+(In).UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi42 – 498ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. nickel cation binding Source: InterPro
  3. nickel-transporting ATPase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Nickel transport, Transport

Keywords - Ligandi

ATP-binding, Nickel, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nickel import ATP-binding protein NikDUniRule annotation (EC:3.6.3.24UniRule annotation)
Gene namesi
Name:nikDUniRule annotation
Ordered Locus Names:BMEII0490
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419 Componenti: Chromosome II

Subcellular locationi

  1. Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

  1. ATP-binding cassette (ABC) transporter complex Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Nickel import ATP-binding protein NikDPRO_0000092618Add
BLAST

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (NikD and NikE), two transmembrane proteins (NikB and NikC) and a solute-binding protein (NikA).UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEII0490.

Structurei

3D structure databases

ProteinModelPortaliQ8YCN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 249244ABC transporterUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

KOiK15587.
OMAiRNLVSAH.
OrthoDBiEOG6T7N3V.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015857. ABC_transpr_NikD.
IPR014138. Nickel_NikD.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02770. nickel_nikD. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51247. NIKD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YCN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRKTLAIEG LTATTVIDGQ QRVLVDNLSL GVQRGRILAL VGASGSGKSM
60 70 80 90 100
TCSAALGVLP PGVTASRGRV TIDGVPYAAN ALRGRHVATI MQNPRSAFNP
110 120 130 140 150
VRTMRDHAIE TLQALGKLSS NPQDQIVHCM RAAGLEDVKT ILSLHPFEMS
160 170 180 190 200
GGMLQRMMIA LALLSEAPFL FADEPTTDLD LVVQLRVLEL LEKLVEERDL
210 220 230 240 250
GILLVTHDMG VVARLAHDVA VLDHGRLIEQ APVMDIFQTP GHEVTRMLVS
260
AHLSLYGMEL NA
Length:262
Mass (Da):28,251
Last modified:March 1, 2002 - v1
Checksum:i773F874C645C344B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008918 Genomic DNA. Translation: AAL53732.1.
PIRiAI3570.
RefSeqiNP_541468.1. NC_003318.1.

Genome annotation databases

EnsemblBacteriaiAAL53732; AAL53732; BMEII0490.
KEGGibme:BMEII0490.
PATRICi17800146. VBIBruMel146950_2407.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008918 Genomic DNA. Translation: AAL53732.1.
PIRiAI3570.
RefSeqiNP_541468.1. NC_003318.1.

3D structure databases

ProteinModelPortaliQ8YCN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BMEII0490.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL53732; AAL53732; BMEII0490.
KEGGibme:BMEII0490.
PATRICi17800146. VBIBruMel146950_2407.

Phylogenomic databases

KOiK15587.
OMAiRNLVSAH.
OrthoDBiEOG6T7N3V.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015857. ABC_transpr_NikD.
IPR014138. Nickel_NikD.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR02770. nickel_nikD. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51247. NIKD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiNIKD_BRUME
AccessioniPrimary (citable) accession number: Q8YCN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2002
Last modified: April 1, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.