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Q8YCN8 (NIKD_BRUME) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nickel import ATP-binding protein NikD

EC=3.6.3.24
Gene names
Name:nikD
Ordered Locus Names:BMEII0490
OrganismBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]
Taxonomic identifier224914 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system By similarity.

Catalytic activity

ATP + H2O + Ni2+(Out) = ADP + phosphate + Ni2+(In).

Subunit structure

The complex is composed of two ATP-binding proteins (NikD and NikE), two transmembrane proteins (NikB and NikC) and a solute-binding protein (NikA) Potential.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. [View classification]

Contains 1 ABC transporter domain.

Ontologies

Keywords
   Biological processIon transport
Nickel transport
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   LigandATP-binding
Nickel
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentplasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

nickel cation binding

Inferred from electronic annotation. Source: InterPro

nickel-transporting ATPase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Nickel import ATP-binding protein NikD
PRO_0000092618

Regions

Domain6 – 249244ABC transporter
Nucleotide binding42 – 498ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q8YCN8 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 773F874C645C344B

FASTA26228,251
        10         20         30         40         50         60 
MTRKTLAIEG LTATTVIDGQ QRVLVDNLSL GVQRGRILAL VGASGSGKSM TCSAALGVLP 

        70         80         90        100        110        120 
PGVTASRGRV TIDGVPYAAN ALRGRHVATI MQNPRSAFNP VRTMRDHAIE TLQALGKLSS 

       130        140        150        160        170        180 
NPQDQIVHCM RAAGLEDVKT ILSLHPFEMS GGMLQRMMIA LALLSEAPFL FADEPTTDLD 

       190        200        210        220        230        240 
LVVQLRVLEL LEKLVEERDL GILLVTHDMG VVARLAHDVA VLDHGRLIEQ APVMDIFQTP 

       250        260 
GHEVTRMLVS AHLSLYGMEL NA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008918 Genomic DNA. Translation: AAL53732.1.
PIRAI3570.
RefSeqNP_541468.1. NC_003318.1.

3D structure databases

ProteinModelPortalQ8YCN8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224914.BMEII0490.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAL53732; AAL53732; BMEII0490.
GeneID1198262.
KEGGbme:BMEII0490.
PATRIC17800146. VBIBruMel146950_2407.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK15587.
OMAHAFEMSG.
OrthoDBEOG6T7N3V.
ProtClustDBPRK10418.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015857. ABC_transpr_NikD.
IPR014138. Nickel_NikD.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR02770. nickel_nikD. 1 hit.
PROSITEPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51247. NIKD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNIKD_BRUME
AccessionPrimary (citable) accession number: Q8YCN8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella melitensis

Brucella melitensis (strain 16M): entries and gene names