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Q8YCN8

- NIKD_BRUME

UniProt

Q8YCN8 - NIKD_BRUME

Protein

Nickel import ATP-binding protein NikD

Gene

nikD

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system.UniRule annotation

    Catalytic activityi

    ATP + H2O + Ni2+(Out) = ADP + phosphate + Ni2+(In).UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi42 – 498ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. nickel cation binding Source: InterPro
    3. nickel-transporting ATPase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Ion transport, Nickel transport, Transport

    Keywords - Ligandi

    ATP-binding, Nickel, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nickel import ATP-binding protein NikDUniRule annotation (EC:3.6.3.24UniRule annotation)
    Gene namesi
    Name:nikDUniRule annotation
    Ordered Locus Names:BMEII0490
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome II

    Subcellular locationi

    Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

    GO - Cellular componenti

    1. ATP-binding cassette (ABC) transporter complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262Nickel import ATP-binding protein NikDPRO_0000092618Add
    BLAST

    Interactioni

    Subunit structurei

    The complex is composed of two ATP-binding proteins (NikD and NikE), two transmembrane proteins (NikB and NikC) and a solute-binding protein (NikA).UniRule annotation

    Protein-protein interaction databases

    STRINGi224914.BMEII0490.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YCN8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 249244ABC transporterUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily. Nickel importer (TC 3.A.1.5.3) family. [View classification]UniRule annotation
    Contains 1 ABC transporter domain.UniRule annotation

    Phylogenomic databases

    KOiK15587.
    OMAiGDHASET.
    OrthoDBiEOG6T7N3V.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR015857. ABC_transpr_NikD.
    IPR014138. Nickel_NikD.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR02770. nickel_nikD. 1 hit.
    PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    PS51247. NIKD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8YCN8-1 [UniParc]FASTAAdd to Basket

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    MTRKTLAIEG LTATTVIDGQ QRVLVDNLSL GVQRGRILAL VGASGSGKSM    50
    TCSAALGVLP PGVTASRGRV TIDGVPYAAN ALRGRHVATI MQNPRSAFNP 100
    VRTMRDHAIE TLQALGKLSS NPQDQIVHCM RAAGLEDVKT ILSLHPFEMS 150
    GGMLQRMMIA LALLSEAPFL FADEPTTDLD LVVQLRVLEL LEKLVEERDL 200
    GILLVTHDMG VVARLAHDVA VLDHGRLIEQ APVMDIFQTP GHEVTRMLVS 250
    AHLSLYGMEL NA 262
    Length:262
    Mass (Da):28,251
    Last modified:March 1, 2002 - v1
    Checksum:i773F874C645C344B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008918 Genomic DNA. Translation: AAL53732.1.
    PIRiAI3570.
    RefSeqiNP_541468.1. NC_003318.1.

    Genome annotation databases

    EnsemblBacteriaiAAL53732; AAL53732; BMEII0490.
    GeneIDi1198262.
    KEGGibme:BMEII0490.
    PATRICi17800146. VBIBruMel146950_2407.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008918 Genomic DNA. Translation: AAL53732.1 .
    PIRi AI3570.
    RefSeqi NP_541468.1. NC_003318.1.

    3D structure databases

    ProteinModelPortali Q8YCN8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEII0490.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL53732 ; AAL53732 ; BMEII0490 .
    GeneIDi 1198262.
    KEGGi bme:BMEII0490.
    PATRICi 17800146. VBIBruMel146950_2407.

    Phylogenomic databases

    KOi K15587.
    OMAi GDHASET.
    OrthoDBi EOG6T7N3V.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR015857. ABC_transpr_NikD.
    IPR014138. Nickel_NikD.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR02770. nickel_nikD. 1 hit.
    PROSITEi PS00211. ABC_TRANSPORTER_1. 1 hit.
    PS50893. ABC_TRANSPORTER_2. 1 hit.
    PS51247. NIKD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiNIKD_BRUME
    AccessioniPrimary (citable) accession number: Q8YCN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3