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Protein

Alkyl hydroperoxide reductase AhpD

Gene

ahpD

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.UniRule annotation

Catalytic activityi

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311Proton donorUniRule annotation
Active sitei134 – 1341Cysteine sulfenic acid (-SOH) intermediateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase, Peroxidase

Protein family/group databases

PeroxiBasei4603. BmeAhpD.

Names & Taxonomyi

Protein namesi
Recommended name:
Alkyl hydroperoxide reductase AhpDUniRule annotation (EC:1.11.1.15UniRule annotation)
Alternative name(s):
Alkylhydroperoxidase AhpDUniRule annotation
Gene namesi
Name:ahpDUniRule annotation
Ordered Locus Names:BMEII0578
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 175175Alkyl hydroperoxide reductase AhpDPRO_0000359480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi131 ↔ 134By similarity
Disulfide bondi134 – 134Interchain (with AhpC); in linked formUniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_1995.

Structurei

3D structure databases

ProteinModelPortaliQ8YCF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AhpD family.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4108X7C. Bacteria.
COG2128. LUCA.
HOGENOMiHOG000261487.
KOiK04756.
OMAiAIMAMNN.
OrthoDBiEOG6PCQ0G.

Family and domain databases

Gene3Di1.20.1290.10. 1 hit.
HAMAPiMF_01676. AhpD.
InterProiIPR004674. AhpD.
IPR029032. AhpD-like.
IPR004675. AhpD_core.
IPR003779. CMD-like.
[Graphical view]
PfamiPF02627. CMD. 1 hit.
[Graphical view]
SUPFAMiSSF69118. SSF69118. 1 hit.
TIGRFAMsiTIGR00777. ahpD. 1 hit.
TIGR00778. ahpD_dom. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8YCF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIDDLKSKI PDFAKDVRLN LSSMASDETL TPQQKYGLFV ACGIASRNAD
60 70 80 90 100
VRKALVAEAA GKVDASVIQA AKAAASIMGM NNVYYRFVHL ASNKDYRTMP
110 120 130 140 150
ARLRMNVISN PGVDKVDFEL WSLAVSAING CGMCIDAHED VLRKANVTAE
160 170
AIQAAVRFAS IIQSAAIALE AADTE
Length:175
Mass (Da):18,769
Last modified:March 1, 2002 - v1
Checksum:iD8E719D7F4B571CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008918 Genomic DNA. Translation: AAL53820.1.
PIRiAI3581.
RefSeqiWP_004682000.1. NZ_GG703779.1.

Genome annotation databases

EnsemblBacteriaiAAL53820; AAL53820; BMEII0578.
KEGGibme:BMEII0578.
PATRICi17799950. VBIBruMel146950_2309.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008918 Genomic DNA. Translation: AAL53820.1.
PIRiAI3581.
RefSeqiWP_004682000.1. NZ_GG703779.1.

3D structure databases

ProteinModelPortaliQ8YCF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224914.BAWG_1995.

Protein family/group databases

PeroxiBasei4603. BmeAhpD.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAL53820; AAL53820; BMEII0578.
KEGGibme:BMEII0578.
PATRICi17799950. VBIBruMel146950_2309.

Phylogenomic databases

eggNOGiENOG4108X7C. Bacteria.
COG2128. LUCA.
HOGENOMiHOG000261487.
KOiK04756.
OMAiAIMAMNN.
OrthoDBiEOG6PCQ0G.

Family and domain databases

Gene3Di1.20.1290.10. 1 hit.
HAMAPiMF_01676. AhpD.
InterProiIPR004674. AhpD.
IPR029032. AhpD-like.
IPR004675. AhpD_core.
IPR003779. CMD-like.
[Graphical view]
PfamiPF02627. CMD. 1 hit.
[Graphical view]
SUPFAMiSSF69118. SSF69118. 1 hit.
TIGRFAMsiTIGR00777. ahpD. 1 hit.
TIGR00778. ahpD_dom. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiAHPD_BRUME
AccessioniPrimary (citable) accession number: Q8YCF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: March 1, 2002
Last modified: November 11, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.