Reviewed, UniProtKB/Swiss-Prot Q8YCF2 (AHPD_BRUME)

Names and origin

Protein names

Recommended name:
    Alkyl hydroperoxide reductase ahpD
    EC=1.11.1.15
Alternative name(s):
    Alkylhydroperoxidase ahpD

Gene names

Name:	ahpD
Ordered Locus Names:	BMEII0578

Organism

Brucella melitensis [Complete proteome] [HAMAP]

Taxonomic identifier

29459 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the ahpC active site cysteine residues and for the regeneration of the ahpC enzyme activity By similarity.
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Sequence similarities	Belongs to the ahpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alkyl hydroperoxide reductase activity Inferred from electronic annotation. Source: HAMAP peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 175	175	Alkyl hydroperoxide reductase ahpD HAMAP MF_01676		PRO_0000359480
Sites
	Active site	131	1	Proton donor By similarity
	Active site	134	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	131 ↔ 134		Alternate By similarity
	Disulfide bond	134		Interchain (with ahpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8YCF2-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: D8E719D7F4B571CA	FASTA	175	18,769
	10 20 30 40 50 60 MSIDDLKSKI PDFAKDVRLN LSSMASDETL TPQQKYGLFV ACGIASRNAD VRKALVAEAA 70 80 90 100 110 120 GKVDASVIQA AKAAASIMGM NNVYYRFVHL ASNKDYRTMP ARLRMNVISN PGVDKVDFEL 130 140 150 160 170 WSLAVSAING CGMCIDAHED VLRKANVTAE AIQAAVRFAS IIQSAAIALE AADTE

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed: 11756688] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094 / Biotype 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008918 Genomic DNA. Translation: AAL53820.1.
PIR	AI3581.
RefSeq	NP_541556.1.
3D structure databases
HSSP	HSSP built from PDB template 1ME5 based on UniProtKB Q57353.
ModBase	Search...
Protein family/group databases
PeroxiBase	4603. BmeAhpD.
Genome annotation databases
GeneID	1198350.
GenomeReviews	Gene locus BMEII0578 in contig AE008918_GR.
KEGG	bme:BMEII0578.
NMPDR	fig|224914.1.peg.2638.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8YCF2.
OMA	MAMNNVY.
Enzyme and pathway databases
BioCyc	BMEL224914:BMEII0578-MON.
Family and domain databases
HAMAP	MF_01676. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. ahpD. 1 hit. TIGR00778. ahpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_BRUME

Accession

Primary (citable) accession number: Q8YCF2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	March 1, 2002
Last modified:	November 3, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)