ID   FDHD_BRUME              Reviewed;         269 AA.
AC   Q8YCE3;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   27-MAR-2024, entry version 110.
DE   RecName: Full=Sulfur carrier protein FdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN   Name=fdhD {ECO:0000255|HAMAP-Rule:MF_00187};
GN   OrderedLocusNames=BMEII0588;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- FUNCTION: Required for formate dehydrogenase (FDH) activity. Acts as a
CC       sulfur carrier protein that transfers sulfur from IscS to the
CC       molybdenum cofactor prior to its insertion into FDH.
CC       {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00187}.
CC   -!- SIMILARITY: Belongs to the FdhD family. {ECO:0000255|HAMAP-
CC       Rule:MF_00187}.
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DR   EMBL; AE008918; AAL53830.1; -; Genomic_DNA.
DR   PIR; AC3583; AC3583.
DR   RefSeq; WP_004681982.1; NZ_GG703779.1.
DR   AlphaFoldDB; Q8YCE3; -.
DR   SMR; Q8YCE3; -.
DR   GeneID; 29595913; -.
DR   KEGG; bme:BMEII0588; -.
DR   KEGG; bmel:DK63_2657; -.
DR   PATRIC; fig|224914.52.peg.2785; -.
DR   eggNOG; COG1526; Bacteria.
DR   Proteomes; UP000000419; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0097163; F:sulfur carrier activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016783; F:sulfurtransferase activity; IEA:InterPro.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.10.20.10; -; 1.
DR   Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR   HAMAP; MF_00187; FdhD; 1.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   InterPro; IPR003786; FdhD.
DR   NCBIfam; TIGR00129; fdhD_narQ; 1.
DR   PANTHER; PTHR30592; FORMATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR30592:SF1; SULFUR CARRIER PROTEIN FDHD; 1.
DR   Pfam; PF02634; FdhD-NarQ; 1.
DR   PIRSF; PIRSF015626; FdhD; 1.
DR   SUPFAM; SSF53927; Cytidine deaminase-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Molybdenum cofactor biosynthesis.
FT   CHAIN           1..269
FT                   /note="Sulfur carrier protein FdhD"
FT                   /id="PRO_0000152894"
FT   ACT_SITE        111
FT                   /note="Cysteine persulfide intermediate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00187"
SQ   SEQUENCE   269 AA;  28876 MW;  33117EBD4F459A99 CRC64;
     MTNQKISRDV HHLAHRMSGF QESSRIVPEE APIAMSYNGT TQAVMMATPG DLEDFAIGFS
     LTENIVTRIE EIEALDIVAF ESGIDIQMKL AKQPEQRLSA RRRFMAGQVG CGLCGIDSIE
     QALRPLHPLE ECSTTFTTRD IAAAVASLGA AQALNAKTHA THGAGFFRPG EGLFAVREDI
     GRHNALDKLI GAVAREGLLA EEGIVAITSR VSVEMVQKAV MLGVPVLAAI SAPTALAIRT
     AEAANLTLVA LVRDEEFDIY THCGRIIEG
//