Q8YCB1 (UGPC_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
sn-glycerol-3-phosphate import ATP-binding protein UgpC
EC=3.6.3.20

Gene names

Name:	ugpC
Ordered Locus Names:	BMEII0621

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella melitensis › Brucella melitensis bv. 1

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system By similarity.
Catalytic activity	ATP + H2O + glycerol-3-phosphate(Out) = ADP + phosphate + glycerol-3-phosphate(In).
Subunit structure	The complex is composed of two ATP-binding proteins (UgpC), two transmembrane proteins (UgpA and UgpE) and a solute-binding protein (UgpB) Potential.
Subcellular location	Cell inner membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the ABC transporter superfamily. sn-glycerol-3-phosphate importer (TC 3.A.1.1.3) family. [View classification] Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC carbohydrate transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	ATP-binding cassette (ABC) transporter complex Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerol-3-phosphate-transporting ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	sn-glycerol-3-phosphate import ATP-binding protein UgpC		PRO_0000289736
Regions
	Domain	4 – 235	232	ABC transporter
	Nucleotide binding	37 – 44	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8YCB1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 37A582BE843EBBE1	FASTA	351	38,531
	10 20 30 40 50 60 MSKIVLDNVR KSYGGNIEVI KGVSLEIADG EFVVLVGPSG CGKSTLLRMI AGLESITSGT 70 80 90 100 110 120 ISIGERVVNN VEPAERDIAM VFQNYALYPH MTVRENLAYG LKNRKTPKEE IERRIAKAAK 130 140 150 160 170 180 VLEIEQFLER KPRQLSGGQR QRVAMGRAIV REPAAFLFDE PLSNLDAKLR VQMRVEIKRL 190 200 210 220 230 240 QRSLGTTSVY VTHDQMEAMT MADRLVVLNA GHIEQVGTPI ELYEKPASIF VATFIGSPSM 250 260 270 280 290 300 NLLQSPESAA WQPGRAITLP SGGYTFGVRP EDIRILEEGD QDADGFNAQV RIEAVELVGA 310 320 330 340 350 ESYIHAALSD GKPLIFRVAG RSTHNIDEMV RVGASATDVH IFGADGRRVS D

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008918 Genomic DNA. Translation: AAL53863.1.
PIR	AD3587.
RefSeq	NP_541599.1. NC_003318.1.
3D structure databases
ProteinModelPortal	Q8YCB1.
ModBase	Search...
Protein-protein interaction databases
STRING	224914.BMEII0621.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL53863; AAL53863; BMEII0621.
GeneID	1198393.
KEGG	bme:BMEII0621.
PATRIC	17799854. VBIBruMel146950_2261.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K05816.
OMA	ALMGLRP.
ProtClustDB	PRK11650.
Family and domain databases
Gene3D	2.40.50.140. 1 hit.
InterPro	IPR003593. AAA+_ATPase. IPR017922. ABC_G3P_import_ATP-bd. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR008995. Mo/tungstate-bd_C_term_dom. IPR012340. NA-bd_OB-fold. IPR027417. P-loop_NTPase. IPR013611. Transp-assoc_OB_typ2. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. PF08402. TOBE_2. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
SUPFAM	SSF50331. MOP_like. 1 hit. SSF52540. SSF52540. 1 hit.
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. PS51315. UGPC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UGPC_BRUME

Accession

Primary (citable) accession number: Q8YCB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	March 1, 2002
Last modified:	May 29, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program