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Q8YC47

- GLMS_BRUME

UniProt

Q8YC47 - GLMS_BRUME

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, BMEII0685
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei602 – 6021For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciBMEL224914:GCJ0-2809-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:BMEII0685
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome II

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 607606Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135309Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEII0685.

Structurei

3D structure databases

ProteinModelPortaliQ8YC47.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2
Add
BLAST
Domaini283 – 422140SIS 1
Add
BLAST
Domaini455 – 597143SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

HOGENOMiHOG000258896.
KOiK00820.
OMAiGHKHTLA.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8YC47-1 [UniParc]FASTAAdd to Basket

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MCGIIGIIGN DEVAPRLVDA LKRLEYRGYD SAGIATLQNG RLDRRRAEGK    50
LVNLEKRLAG EPLPGVIGIG HTRWATHGRP VEHNAHPHIT TRLAVVHNGI 100
IENFAELRAM LEAEGRKFET ETDTEAVAHL VTRELEKGKS PVEAVRDCLP 150
HLKGAFALAF LFEGDEELLI GARQGPPLAV GYGEGEMFLG SDAIALAPFT 200
DTISYLEDGD WAVLTRNGVS IYDENNKPVE RPVQKSQNTN MLVSKGNHRH 250
FMQKEMFEQP EVISHTLANY LDFTTGKVRK EAIGIDFSKV DRLTITACGT 300
AYYAATVAKY WFEQIARLPV DSDIASEFRY REMPLSKDSL AMFVSQSGET 350
ADTLASLRYC KAQGLKIASV LNVTGSTIAR ESDAVFPTLA GPEIGVASTK 400
AFTCQLSAMA SLAIAAARAR GAIDEVREQE LVHQLSEAPR FINQVLKLED 450
QIAVVCHDLS KVNHVLYLGR GTSFPLAMEG ALKLKEISYI HAEGYAAGEL 500
KHGPIALIDE TMPVIVIAPS DRLYEKTVSN MQEVAARGGR IILITDKKGA 550
ESASIDTMAT IVLPEVPEFI SPLVYALPIQ MLAYHTAVLM GTDVDQPRNL 600
AKSVTVE 607
Length:607
Mass (Da):66,330
Last modified:January 23, 2007 - v4
Checksum:i8DFBB72BC3DB000F
GO

Sequence cautioni

The sequence AAL53927.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008918 Genomic DNA. Translation: AAL53927.1. Different initiation.
PIRiAD3595.
RefSeqiNP_541663.1. NC_003318.1.

Genome annotation databases

EnsemblBacteriaiAAL53927; AAL53927; BMEII0685.
GeneIDi1198457.
KEGGibme:BMEII0685.
PATRICi17856110. VBIBruMel92729_3017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008918 Genomic DNA. Translation: AAL53927.1 . Different initiation.
PIRi AD3595.
RefSeqi NP_541663.1. NC_003318.1.

3D structure databases

ProteinModelPortali Q8YC47.
ModBasei Search...

Protein-protein interaction databases

STRINGi 224914.BMEII0685.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL53927 ; AAL53927 ; BMEII0685 .
GeneIDi 1198457.
KEGGi bme:BMEII0685.
PATRICi 17856110. VBIBruMel92729_3017.

Phylogenomic databases

HOGENOMi HOG000258896.
KOi K00820.
OMAi GHKHTLA.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci BMEL224914:GCJ0-2809-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiGLMS_BRUME
AccessioniPrimary (citable) accession number: Q8YC47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 84 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi