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Q8YC47

- GLMS_BRUME

UniProt

Q8YC47 - GLMS_BRUME

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei602 – 6021For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciBMEL224914:GCJ0-2809-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:BMEII0685
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome II

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 607606Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135309Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi224914.BMEII0685.

Structurei

3D structure databases

ProteinModelPortaliQ8YC47.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini283 – 422140SIS 1UniRule annotationAdd
BLAST
Domaini455 – 597143SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

HOGENOMiHOG000258896.
KOiK00820.
OMAiGHKHTLA.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8YC47-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIIGIIGN DEVAPRLVDA LKRLEYRGYD SAGIATLQNG RLDRRRAEGK
60 70 80 90 100
LVNLEKRLAG EPLPGVIGIG HTRWATHGRP VEHNAHPHIT TRLAVVHNGI
110 120 130 140 150
IENFAELRAM LEAEGRKFET ETDTEAVAHL VTRELEKGKS PVEAVRDCLP
160 170 180 190 200
HLKGAFALAF LFEGDEELLI GARQGPPLAV GYGEGEMFLG SDAIALAPFT
210 220 230 240 250
DTISYLEDGD WAVLTRNGVS IYDENNKPVE RPVQKSQNTN MLVSKGNHRH
260 270 280 290 300
FMQKEMFEQP EVISHTLANY LDFTTGKVRK EAIGIDFSKV DRLTITACGT
310 320 330 340 350
AYYAATVAKY WFEQIARLPV DSDIASEFRY REMPLSKDSL AMFVSQSGET
360 370 380 390 400
ADTLASLRYC KAQGLKIASV LNVTGSTIAR ESDAVFPTLA GPEIGVASTK
410 420 430 440 450
AFTCQLSAMA SLAIAAARAR GAIDEVREQE LVHQLSEAPR FINQVLKLED
460 470 480 490 500
QIAVVCHDLS KVNHVLYLGR GTSFPLAMEG ALKLKEISYI HAEGYAAGEL
510 520 530 540 550
KHGPIALIDE TMPVIVIAPS DRLYEKTVSN MQEVAARGGR IILITDKKGA
560 570 580 590 600
ESASIDTMAT IVLPEVPEFI SPLVYALPIQ MLAYHTAVLM GTDVDQPRNL

AKSVTVE
Length:607
Mass (Da):66,330
Last modified:January 23, 2007 - v4
Checksum:i8DFBB72BC3DB000F
GO

Sequence cautioni

The sequence AAL53927.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008918 Genomic DNA. Translation: AAL53927.1. Different initiation.
PIRiAD3595.
RefSeqiNP_541663.1. NC_003318.1.

Genome annotation databases

EnsemblBacteriaiAAL53927; AAL53927; BMEII0685.
GeneIDi1198457.
KEGGibme:BMEII0685.
PATRICi17856110. VBIBruMel92729_3017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008918 Genomic DNA. Translation: AAL53927.1 . Different initiation.
PIRi AD3595.
RefSeqi NP_541663.1. NC_003318.1.

3D structure databases

ProteinModelPortali Q8YC47.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEII0685.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL53927 ; AAL53927 ; BMEII0685 .
GeneIDi 1198457.
KEGGi bme:BMEII0685.
PATRICi 17856110. VBIBruMel92729_3017.

Phylogenomic databases

HOGENOMi HOG000258896.
KOi K00820.
OMAi GHKHTLA.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci BMEL224914:GCJ0-2809-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiGLMS_BRUME
AccessioniPrimary (citable) accession number: Q8YC47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 86 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3