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Q8YC29

- RIMO_BRUME

UniProt

Q8YC29 - RIMO_BRUME

Protein

Ribosomal protein S12 methylthiotransferase RimO

Gene

rimO

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.UniRule annotation

    Cofactori

    Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi13 – 131Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi49 – 491Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi78 – 781Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi145 – 1451Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi149 – 1491Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation
    Metal bindingi152 – 1521Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
    2. iron ion binding Source: UniProtKB-HAMAP
    3. transferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid Source: UniProtKB-HAMAP
    2. RNA modification Source: InterPro

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal protein S12 methylthiotransferase RimOUniRule annotation (EC:2.-.-.-UniRule annotation)
    Short name:
    S12 MTTaseUniRule annotation
    Short name:
    S12 methylthiotransferaseUniRule annotation
    Alternative name(s):
    Ribosome maturation factor RimOUniRule annotation
    Gene namesi
    Name:rimOUniRule annotation
    Ordered Locus Names:BMEII0703
    OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
    Taxonomic identifieri224914 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000419: Chromosome II

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 437437Ribosomal protein S12 methylthiotransferase RimOPRO_0000374724Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi224914.BMEII0703.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8YC29.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 114111MTTase N-terminalUniRule annotationAdd
    BLAST
    Domaini372 – 43766TRAMUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the methylthiotransferase family. RimO subfamily.UniRule annotation
    Contains 1 MTTase N-terminal domain.UniRule annotation
    Contains 1 TRAM domain.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000224766.
    KOiK14441.
    OMAiPHDPFID.
    OrthoDBiEOG6P5ZD8.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    3.80.30.20. 1 hit.
    HAMAPiMF_01865. MTTase_RimO.
    InterProiIPR006638. Elp3/MiaB/NifB.
    IPR023970. MeThioTfrase/rSAM.
    IPR005839. Methylthiotransferase.
    IPR020612. Methylthiotransferase_CS.
    IPR013848. Methylthiotransferase_N.
    IPR012340. NA-bd_OB-fold.
    IPR005840. Ribosomal_S12_MeSTrfase_RimO.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    IPR002792. TRAM_dom.
    [Graphical view]
    PANTHERiPTHR11918. PTHR11918. 1 hit.
    PfamiPF04055. Radical_SAM. 1 hit.
    PF00919. UPF0004. 1 hit.
    [Graphical view]
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00089. TIGR00089. 1 hit.
    TIGR01125. TIGR01125. 1 hit.
    PROSITEiPS51449. MTTASE_N. 1 hit.
    PS01278. MTTASE_RADICAL. 1 hit.
    PS50926. TRAM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8YC29-1 [UniParc]FASTAAdd to Basket

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    MSAPRVSFVS LGCPKALVDS ERIITGLRSE GYEISRKHDG ADLVIVNTCG    50
    FLDSARDESL EAIGLALNEN GKVIVTGCLG AEPDVIRERH PNVLAITGPQ 100
    AYESVMNAVH EVAPPAHDPF VDLVPPQGVK LTPRHYAYLK ISEGCSNRCS 150
    FCIIPALRGD LVSRPINEVL REAEKLVQAG VKEILVISQD TSAYGLDIKY 200
    QEAMWQDRTV RTKFLDLSRE LGEMGVWVRM HYVYPYPHVD EVIPLMAEGK 250
    ILPYLDIPFQ HASPAVLKNM RRPAHQEKTS RRIQAWRETC PDLAVRSTFI 300
    VGYPGETEED FQMLLDWLDE AKIERAGCFK YEAVKGAKAN DLGLEQVPEE 350
    VKEARWHRFM AKQQQISTNL LKKKVGKRLP VIIDEANGTI GKGRTRYDAP 400
    EIDGSVHISS RRPLRVGDIV TVKIEASDAY DLHGTAV 437
    Length:437
    Mass (Da):48,774
    Last modified:March 1, 2002 - v1
    Checksum:i530B6217DDF24656
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008918 Genomic DNA. Translation: AAL53945.1.
    PIRiAF3597.
    RefSeqiNP_541681.1. NC_003318.1.

    Genome annotation databases

    EnsemblBacteriaiAAL53945; AAL53945; BMEII0703.
    GeneIDi1198475.
    KEGGibme:BMEII0703.
    PATRICi17799660. VBIBruMel146950_2167.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008918 Genomic DNA. Translation: AAL53945.1 .
    PIRi AF3597.
    RefSeqi NP_541681.1. NC_003318.1.

    3D structure databases

    ProteinModelPortali Q8YC29.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224914.BMEII0703.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAL53945 ; AAL53945 ; BMEII0703 .
    GeneIDi 1198475.
    KEGGi bme:BMEII0703.
    PATRICi 17799660. VBIBruMel146950_2167.

    Phylogenomic databases

    HOGENOMi HOG000224766.
    KOi K14441.
    OMAi PHDPFID.
    OrthoDBi EOG6P5ZD8.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    3.80.30.20. 1 hit.
    HAMAPi MF_01865. MTTase_RimO.
    InterProi IPR006638. Elp3/MiaB/NifB.
    IPR023970. MeThioTfrase/rSAM.
    IPR005839. Methylthiotransferase.
    IPR020612. Methylthiotransferase_CS.
    IPR013848. Methylthiotransferase_N.
    IPR012340. NA-bd_OB-fold.
    IPR005840. Ribosomal_S12_MeSTrfase_RimO.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    IPR002792. TRAM_dom.
    [Graphical view ]
    PANTHERi PTHR11918. PTHR11918. 1 hit.
    Pfami PF04055. Radical_SAM. 1 hit.
    PF00919. UPF0004. 1 hit.
    [Graphical view ]
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00089. TIGR00089. 1 hit.
    TIGR01125. TIGR01125. 1 hit.
    PROSITEi PS51449. MTTASE_N. 1 hit.
    PS01278. MTTASE_RADICAL. 1 hit.
    PS50926. TRAM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 16M / ATCC 23456 / NCTC 10094.

    Entry informationi

    Entry nameiRIMO_BRUME
    AccessioniPrimary (citable) accession number: Q8YC29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella melitensis
      Brucella melitensis (strain 16M): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3