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Q8YC29

- RIMO_BRUME

UniProt

Q8YC29 - RIMO_BRUME

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Protein
Ribosomal protein S12 methylthiotransferase RimO
Gene
rimO, BMEII0703
Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 By similarity.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131Iron-sulfur (4Fe-4S) By similarity
Metal bindingi49 – 491Iron-sulfur (4Fe-4S) By similarity
Metal bindingi78 – 781Iron-sulfur (4Fe-4S) By similarity
Metal bindingi145 – 1451Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal bindingi149 – 1491Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal bindingi152 – 1521Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. iron ion binding Source: UniProtKB-HAMAP
  3. transferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA modification Source: InterPro
  2. peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal protein S12 methylthiotransferase RimO (EC:2.-.-.-)
Short name:
S12 MTTase
Short name:
S12 methylthiotransferase
Alternative name(s):
Ribosome maturation factor RimO
Gene namesi
Name:rimO
Ordered Locus Names:BMEII0703
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000419: Chromosome II

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Ribosomal protein S12 methylthiotransferase RimOUniRule annotation
PRO_0000374724Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi224914.BMEII0703.

Structurei

3D structure databases

ProteinModelPortaliQ8YC29.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 114111MTTase N-terminal
Add
BLAST
Domaini372 – 43766TRAM
Add
BLAST

Sequence similaritiesi

Contains 1 TRAM domain.

Phylogenomic databases

HOGENOMiHOG000224766.
KOiK14441.
OMAiPHDPFID.
OrthoDBiEOG6P5ZD8.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
3.80.30.20. 1 hit.
HAMAPiMF_01865. MTTase_RimO.
InterProiIPR006638. Elp3/MiaB/NifB.
IPR023970. MeThioTfrase/rSAM.
IPR005839. Methylthiotransferase.
IPR020612. Methylthiotransferase_CS.
IPR013848. Methylthiotransferase_N.
IPR012340. NA-bd_OB-fold.
IPR005840. Ribosomal_S12_MeSTrfase_RimO.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
IPR002792. TRAM_dom.
[Graphical view]
PANTHERiPTHR11918. PTHR11918. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
PF00919. UPF0004. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00089. TIGR00089. 1 hit.
TIGR01125. TIGR01125. 1 hit.
PROSITEiPS51449. MTTASE_N. 1 hit.
PS01278. MTTASE_RADICAL. 1 hit.
PS50926. TRAM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8YC29-1 [UniParc]FASTAAdd to Basket

« Hide

MSAPRVSFVS LGCPKALVDS ERIITGLRSE GYEISRKHDG ADLVIVNTCG    50
FLDSARDESL EAIGLALNEN GKVIVTGCLG AEPDVIRERH PNVLAITGPQ 100
AYESVMNAVH EVAPPAHDPF VDLVPPQGVK LTPRHYAYLK ISEGCSNRCS 150
FCIIPALRGD LVSRPINEVL REAEKLVQAG VKEILVISQD TSAYGLDIKY 200
QEAMWQDRTV RTKFLDLSRE LGEMGVWVRM HYVYPYPHVD EVIPLMAEGK 250
ILPYLDIPFQ HASPAVLKNM RRPAHQEKTS RRIQAWRETC PDLAVRSTFI 300
VGYPGETEED FQMLLDWLDE AKIERAGCFK YEAVKGAKAN DLGLEQVPEE 350
VKEARWHRFM AKQQQISTNL LKKKVGKRLP VIIDEANGTI GKGRTRYDAP 400
EIDGSVHISS RRPLRVGDIV TVKIEASDAY DLHGTAV 437
Length:437
Mass (Da):48,774
Last modified:March 1, 2002 - v1
Checksum:i530B6217DDF24656
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008918 Genomic DNA. Translation: AAL53945.1.
PIRiAF3597.
RefSeqiNP_541681.1. NC_003318.1.

Genome annotation databases

EnsemblBacteriaiAAL53945; AAL53945; BMEII0703.
GeneIDi1198475.
KEGGibme:BMEII0703.
PATRICi17799660. VBIBruMel146950_2167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008918 Genomic DNA. Translation: AAL53945.1 .
PIRi AF3597.
RefSeqi NP_541681.1. NC_003318.1.

3D structure databases

ProteinModelPortali Q8YC29.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224914.BMEII0703.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAL53945 ; AAL53945 ; BMEII0703 .
GeneIDi 1198475.
KEGGi bme:BMEII0703.
PATRICi 17799660. VBIBruMel146950_2167.

Phylogenomic databases

HOGENOMi HOG000224766.
KOi K14441.
OMAi PHDPFID.
OrthoDBi EOG6P5ZD8.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
3.80.30.20. 1 hit.
HAMAPi MF_01865. MTTase_RimO.
InterProi IPR006638. Elp3/MiaB/NifB.
IPR023970. MeThioTfrase/rSAM.
IPR005839. Methylthiotransferase.
IPR020612. Methylthiotransferase_CS.
IPR013848. Methylthiotransferase_N.
IPR012340. NA-bd_OB-fold.
IPR005840. Ribosomal_S12_MeSTrfase_RimO.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
IPR002792. TRAM_dom.
[Graphical view ]
PANTHERi PTHR11918. PTHR11918. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
PF00919. UPF0004. 1 hit.
[Graphical view ]
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00089. TIGR00089. 1 hit.
TIGR01125. TIGR01125. 1 hit.
PROSITEi PS51449. MTTASE_N. 1 hit.
PS01278. MTTASE_RADICAL. 1 hit.
PS50926. TRAM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 16M / ATCC 23456 / NCTC 10094.

Entry informationi

Entry nameiRIMO_BRUME
AccessioniPrimary (citable) accession number: Q8YC29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: March 1, 2002
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi