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Protein

Probable acid stress chaperone HdeA

Gene

hdeA

Organism
Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins.

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Probable acid stress chaperone HdeA
Gene namesi
Name:hdeA
Ordered Locus Names:BMEII0906
OrganismiBrucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)
Taxonomic identifieri224914 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000000419 Componenti: Chromosome II

Subcellular locationi

  • Periplasm

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000033863427 – 114Probable acid stress chaperone HdeAAdd BLAST88

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 94

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi224914.BAWG_1681.

Structurei

3D structure databases

ProteinModelPortaliQ8YBJ4.
SMRiQ8YBJ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HdeA family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG41060V2. Bacteria.
ENOG41128BT. LUCA.
HOGENOMiHOG000125826.
KOiK19777.

Family and domain databases

HAMAPiMF_00946. HdeA. 1 hit.
InterProiView protein in InterPro
IPR024972. HdeA.
IPR036831. HdeA_sf.
IPR010486. HNS-dep_expression_A/B.
PfamiView protein in Pfam
PF06411. HdeA. 1 hit.
PIRSFiPIRSF009564. HNS-dep_expression_A. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD065392. HNS-dep_expression_A. 1 hit.
SUPFAMiSSF47752. SSF47752. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8YBJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKALFNKNT ALAAVAILAL SGGAMAESAK THKTDMAKKK VSELTCEDFN
60 70 80 90 100
GLEESFKPTV VGWVVGFNKK GKEEDAVIDV DGIETVTPAI IEACKQEPKA
110
SFWKKAEAEL KKVF
Length:114
Mass (Da):12,332
Last modified:June 10, 2008 - v2
Checksum:i0B5A298253466C53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY518304 Genomic DNA. Translation: AAR98497.1.
AE008918 Genomic DNA. Translation: AAL54148.1.
PIRiAI3622.
RefSeqiWP_002966248.1. NZ_GG703779.1.

Genome annotation databases

EnsemblBacteriaiAAL54148; AAL54148; BMEII0906.
GeneIDi29596047.
KEGGibme:BMEII0906.
bmel:DK63_2344.
PATRICifig|224914.52.peg.2455.

Similar proteinsi

Entry informationi

Entry nameiHDEA_BRUME
AccessioniPrimary (citable) accession number: Q8YBJ4
Secondary accession number(s): Q6R2J7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: October 25, 2017
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella melitensis
    Brucella melitensis (strain 16M): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families