ID   GLUP_BRUME              Reviewed;         412 AA.
AC   Q8YB48;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   27-MAR-2024, entry version 109.
DE   RecName: Full=Glucose/galactose transporter;
GN   Name=gluP; OrderedLocusNames=BMEII1053;
OS   Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094).
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=224914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=16M / ATCC 23456 / NCTC 10094;
RX   PubMed=11756688; DOI=10.1073/pnas.221575398;
RA   DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T.,
RA   Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G.,
RA   Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E.,
RA   Selkov E., Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J.,
RA   Haselkorn R., Kyrpides N.C., Overbeek R.;
RT   "The genome sequence of the facultative intracellular pathogen Brucella
RT   melitensis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002).
CC   -!- FUNCTION: Intake of glucose and galactose. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. FHS
CC       transporter (TC 2.A.1.7) family. {ECO:0000305}.
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DR   EMBL; AE008918; AAL54295.1; -; Genomic_DNA.
DR   PIR; AD3641; AD3641.
DR   RefSeq; WP_011005795.1; NC_003318.1.
DR   AlphaFoldDB; Q8YB48; -.
DR   SMR; Q8YB48; -.
DR   GeneID; 29595792; -.
DR   KEGG; bme:BMEII1053; -.
DR   eggNOG; COG0738; Bacteria.
DR   PhylomeDB; Q8YB48; -.
DR   PRO; PR:Q8YB48; -.
DR   Proteomes; UP000000419; Chromosome II.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005354; F:galactose transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005355; F:glucose transmembrane transporter activity; IEA:InterPro.
DR   CDD; cd17394; MFS_FucP_like; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR   InterPro; IPR005964; Glc/Gal_transptr_bac.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   NCBIfam; TIGR01272; gluP; 1.
DR   PANTHER; PTHR43702; L-FUCOSE-PROTON SYMPORTER; 1.
DR   PANTHER; PTHR43702:SF2; PROTEIN TSGA; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..412
FT                   /note="Glucose/galactose transporter"
FT                   /id="PRO_0000094505"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        62..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        331..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        388..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   412 AA;  43648 MW;  DA5FD6AD00949CF7 CRC64;
     MATSIPTNNP LHTETSSQKN YGFALTSLTL LFFMSGFITC LNDILIPHLK NVFQLNYTQS
     MLIQFCFFGA YFIVSLPAGQ LVKRISYKCG IVVGLIVAAI GCALFIPAAS YRVYALFLGA
     LFVLASGVTI LQVAANPYVT ILGKPETAAS RLTLTQAFNS LGTTVAPVFG AVLILSAATD
     ATVNAEADAV RFPYLLLALA FTVLAIIFAI LKPPDVQEDE PALSDKKEGS AWQYRHLVLG
     AIGIFVYVGA EVSVGSFLVN FLSDPTVAGL SETDAAHHVA YFWGGAMVGR FIGSAAMRYI
     DDGKALAFNA FVAIILLFIT VATTGHIAMW SVLAIGLFNS IMFPTIFSLA LHGLGSHTSQ
     GSGILCLAIV GGAIVPLIQG ALADAIGIHL AFLMPIICYA YIAFYGLIGS KS
//