Q8YB48 (GLUP_BRUME) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose/galactose transporter

Gene names

Name:	gluP
Ordered Locus Names:	BMEII1053

Organism

Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) [Complete proteome] [HAMAP]

Taxonomic identifier

224914 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella melitensis › Brucella melitensis bv. 1

Protein attributes

Sequence length	412 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Intake of glucose and galactose Potential.
Subcellular location	Cell inner membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family. [View classification]

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	Gram-negative-bacterium-type cell wall Inferred from electronic annotation. Source: InterPro integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	galactose transmembrane transporter activity Inferred from electronic annotation. Source: InterPro glucose transmembrane transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 412	412	Glucose/galactose transporter		PRO_0000094505
Regions
	Transmembrane	21 – 41	21	Helical; Potential
	Transmembrane	62 – 82	21	Helical; Potential
	Transmembrane	90 – 110	21	Helical; Potential
	Transmembrane	113 – 133	21	Helical; Potential
	Transmembrane	158 – 178	21	Helical; Potential
	Transmembrane	192 – 212	21	Helical; Potential
	Transmembrane	239 – 259	21	Helical; Potential
	Transmembrane	310 – 330	21	Helical; Potential
	Transmembrane	331 – 351	21	Helical; Potential
	Transmembrane	363 – 383	21	Helical; Potential
	Transmembrane	388 – 408	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8YB48 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: DA5FD6AD00949CF7	FASTA	412	43,648
	10 20 30 40 50 60 MATSIPTNNP LHTETSSQKN YGFALTSLTL LFFMSGFITC LNDILIPHLK NVFQLNYTQS 70 80 90 100 110 120 MLIQFCFFGA YFIVSLPAGQ LVKRISYKCG IVVGLIVAAI GCALFIPAAS YRVYALFLGA 130 140 150 160 170 180 LFVLASGVTI LQVAANPYVT ILGKPETAAS RLTLTQAFNS LGTTVAPVFG AVLILSAATD 190 200 210 220 230 240 ATVNAEADAV RFPYLLLALA FTVLAIIFAI LKPPDVQEDE PALSDKKEGS AWQYRHLVLG 250 260 270 280 290 300 AIGIFVYVGA EVSVGSFLVN FLSDPTVAGL SETDAAHHVA YFWGGAMVGR FIGSAAMRYI 310 320 330 340 350 360 DDGKALAFNA FVAIILLFIT VATTGHIAMW SVLAIGLFNS IMFPTIFSLA LHGLGSHTSQ 370 380 390 400 410 GSGILCLAIV GGAIVPLIQG ALADAIGIHL AFLMPIICYA YIAFYGLIGS KS

References

[1]

"The genome sequence of the facultative intracellular pathogen Brucella melitensis." DelVecchio V.G., Kapatral V., Redkar R.J., Patra G., Mujer C., Los T., Ivanova N., Anderson I., Bhattacharyya A., Lykidis A., Reznik G., Jablonski L., Larsen N., D'Souza M., Bernal A., Mazur M., Goltsman E., Selkov E. , Elzer P.H., Hagius S., O'Callaghan D., Letesson J.-J., Haselkorn R., Kyrpides N.C., Overbeek R. Proc. Natl. Acad. Sci. U.S.A. 99:443-448(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 16M / ATCC 23456 / NCTC 10094.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008918 Genomic DNA. Translation: AAL54295.1.
PIR	AD3641.
RefSeq	NP_542031.1. NC_003318.1.
3D structure databases
ProteinModelPortal	Q8YB48.
ModBase	Search...
Protein-protein interaction databases
STRING	224914.BMEII1053.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAL54295; AAL54295; BMEII1053.
GeneID	1198825.
KEGG	bme:BMEII1053.
PATRIC	17856899. VBIBruMel92729_3408.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HOG000267862.
KO	K02429.
OMA	LKGYKQE.
ProtClustDB	CLSK2303108.
Family and domain databases
InterPro	IPR005964. Glc/Gal_transptr_bac. IPR011701. MFS. IPR016196. MFS_dom_general_subst_transpt. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR01272. gluP. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLUP_BRUME

Accession

Primary (citable) accession number: Q8YB48

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program