Q8YAB5 (ISPD1_LISMO) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 59.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1 EC=2.7.7.60 Alternative name(s): 4-diphosphocytidyl-2C-methyl-D-erythritol synthase 1 MEP cytidylyltransferase 1 Short name=MCT 1 | ||||||
| Gene names |
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| Organism | Listeria monocytogenes | ||||||
| Taxonomic identifier | 1639 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria |
Protein attributes
| Sequence length | 232 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108 |
| Catalytic activity | CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108 |
| Pathway | Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108 |
| Sequence similarities | Belongs to the IspD family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Isoprene biosynthesis |
| Molecular function | Nucleotidyltransferase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 232 | 232 | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1 HAMAP MF_00108 | PRO_0000075587 | |||||
Sites | |||||||||
| Site | 15 | 1 | Transition state stabilizer By similarity | ||||||
| Site | 22 | 1 | Transition state stabilizer By similarity | ||||||
| Site | 153 | 1 | Positions MEP for the nucleophilic attack By similarity | ||||||
| Site | 209 | 1 | Positions MEP for the nucleophilic attack By similarity | ||||||
Sequences
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References
| [1] | "Comparative genomics of Listeria species." Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., Dominguez-Bernal G., Duchaud E. Cossart P.Science 294:849-852(2001) [PubMed: 11679669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-679 / EGD-e / Serovar 1/2a. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL591974 Genomic DNA. Translation: CAD00762.1. |
| PIR | AD1104. |
| RefSeq | NP_463766.1. NC_003210.1. |
3D structure databases | |
| ProteinModelPortal | Q8YAB5. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 987220. |
| GenomeReviews | Gene locus lmo0235 in contig AL591824_GR. |
| KEGG | lmo:lmo0235. |
| PATRIC | 20309514. VBILisMon69206_0243. |
Organism-specific databases | |
| GenoList | LMO0235. |
Phylogenomic databases | |
| HOGENOM | HBG672839. |
| OMA | SKVIVVC. |
| ProtClustDB | PRK13385. |
Enzyme and pathway databases | |
| BioCyc | LMON169963:LMO0235-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00108. IspD. [Tree] |
| InterPro | IPR001228. ISPD_synthase. IPR018294. ISPD_synthase_CS. [Graphical view] |
| KO | K00991. |
| Pfam | PF01128. IspD. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00453. IspD. 1 hit. |
| PROSITE | PS01295. ISPD. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ISPD1_LISMO | ||||||||
| Accession | Primary (citable) accession number: Q8YAB5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with