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Q8YA46 (THIM_LISMO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydroxyethylthiazole kinase

EC=2.7.1.50
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name=TH kinase
Short name=Thz kinase
Gene names
Name:thiM
Ordered Locus Names:lmo0316
OrganismListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) [Reference proteome] [HAMAP]
Taxonomic identifier169963 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole. HAMAP-Rule MF_00228

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00228

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1. HAMAP-Rule MF_00228

Sequence similarities

Belongs to the Thz kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Hydroxyethylthiazole kinase HAMAP-Rule MF_00228
PRO_0000156945

Sites

Binding site421Substrate; via amide nitrogen By similarity
Binding site1181ATP By similarity
Binding site1641ATP By similarity
Binding site1911Substrate; via amide nitrogen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8YA46 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 74A32D672176242C

FASTA26928,052
        10         20         30         40         50         60 
MFDFMTLEKV REKGPLVHNI TNIVVANDSA NGLLAIGASP IMASAKEEMD ELAKMADVLV 

        70         80         90        100        110        120 
INIGTLDGEL VTAMKIAGRA ANVAGTPVVL DPVGVGATSY RRKVVQELLA EIQFAAIRGN 

       130        140        150        160        170        180 
AGELAAIAGE AWEAKGVDAG VGSADVLSIA GKVANEWSTV VIISGEVDVI SDGTRFAKVA 

       190        200        210        220        230        240 
NGSALLPRIT GSGCLLSAVC GSFIAVQDDA FRASVEACAS YAVASEYAEM ELERKLPGSF 

       250        260 
RPLFLDALAS WSVEKTRAKA KIQESGEHK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591974 Genomic DNA. Translation: CAD00843.1.
PIRAE1114.
RefSeqNP_463846.1. NC_003210.1.

3D structure databases

ProteinModelPortalQ8YA46.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING169963.lmo0316.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD00843; CAD00843; CAD00843.
GeneID987532.
KEGGlmo:lmo0316.
PATRIC20309679. VBILisMon69206_0325.

Organism-specific databases

GenoListLMO0316.

Phylogenomic databases

eggNOGCOG2145.
HOGENOMHOG000114352.
KOK00878.
OMAQTFTANV.
OrthoDBEOG628F8M.
PhylomeDBQ8YA46.

Enzyme and pathway databases

BioCycLMON169963:LMO0316-MONOMER.
UniPathwayUPA00060; UER00139.

Family and domain databases

Gene3D3.40.1190.20. 1 hit.
HAMAPMF_00228. Thz_kinase.
InterProIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamPF02110. HK. 1 hit.
[Graphical view]
PIRSFPIRSF000513. Thz_kinase. 1 hit.
PRINTSPR01099. HYETHTZKNASE.
SUPFAMSSF53613. SSF53613. 1 hit.
TIGRFAMsTIGR00694. thiM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTHIM_LISMO
AccessionPrimary (citable) accession number: Q8YA46
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways