Reviewed,
UniProtKB/Swiss-Prot Q8Y9Y4 (IOLA_LISMO)
Last modified
February 9, 2010.
Version 44.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Methylmalonate semialdehyde dehydrogenase [acylating] Short name=MMSA dehydrogenase Short name=MMSDH Short name=MSDH EC=1.2.1.27 Alternative name(s): Malonate semialdehyde dehydrogenase [acetylating] Short name=MSA dehydrogenase EC=1.2.1.18 | ||||
| Gene names |
| ||||
| Organism | Listeria monocytogenes [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 1639 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria |
Protein attributes
| Sequence length | 488 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively By similarity. HAMAP MF_01670 |
| Catalytic activity | 3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. HAMAP MF_01670 2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH. HAMAP MF_01670 |
| Pathway | Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 7/7. HAMAP MF_01670 |
| Subunit structure | Homotetramer By similarity. HAMAP MF_01670 |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. IolA subfamily. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | inositol catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW valine metabolic processInferred from electronic annotation. Source: InterPro |
| Molecular function | malonate-semialdehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: HAMAP methylmalonate-semialdehyde dehydrogenase (acylating) activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 488 | 488 | Methylmalonate semialdehyde dehydrogenase [acylating] HAMAP MF_01670 | PRO_0000352346 | |||||
Regions | |||||||||
| Nucleotide binding | 176 – 180 | 5 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 284 | 1 | Nucleophile By similarity | ||||||
| Binding site | 382 | 1 | NAD By similarity | ||||||
Sequences
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References
| [1] | "Comparative genomics of Listeria species." Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., Dominguez-Bernal G., Duchaud E. Cossart P.Science 294:849-852(2001) [PubMed: 11679669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-679 / EGD-e / Serovar 1/2a. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL591975 Genomic DNA. Translation: CAC98462.1. |
| PIR | AH1122. |
| RefSeq | NP_463913.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1T90 based on UniProtKB P42412. |
| SMR | Q8Y9Y4. Positions 3-481. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 987639. |
| KEGG | lmo:lmo0383. |
Organism-specific databases | |
| ListiList | LMO0383. |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG752218. |
| OMA | HIYTTAS. |
Enzyme and pathway databases | |
| BioCyc | LMON169963:LMO0383-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01670. IolA. [Tree] |
| InterPro | IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. IPR010061. MeMal-semiAld_DH. [Graphical view] |
| Gene3D | G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| PANTHER | PTHR11699. Aldehyde_dehyd. 1 hit. PTHR11699:SF27. MMSDH. 1 hit. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01722. MMSDH. 1 hit. |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | IOLA_LISMO | ||||||||
| Accession | Primary (citable) accession number: Q8Y9Y4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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