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Q8Y9Y4 (IOLA_LISMO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methylmalonate semialdehyde dehydrogenase [acylating]
Short name=MMSA dehydrogenase
Short name=MMSDH
Short name=MSDH
EC=1.2.1.27
Alternative name(s):
Malonate semialdehyde dehydrogenase [acetylating]
Short name=MSA dehydrogenase
EC=1.2.1.18
Gene names
Name:iolA
Ordered Locus Names:lmo0383
OrganismListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) [Reference proteome] [HAMAP]
Taxonomic identifier169963 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Listeriaceae › Listeria ›

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively By similarity. HAMAP-Rule MF_01670

Catalytic activity

3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. HAMAP-Rule MF_01670

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH. HAMAP-Rule MF_01670

Pathway

Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 7/7. HAMAP-Rule MF_01670

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_01670

Sequence similarities

Belongs to the aldehyde dehydrogenase family. IolA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Methylmalonate semialdehyde dehydrogenase [acylating] HAMAP-Rule MF_01670
PRO_0000352346

Regions

Nucleotide binding176 – 1805NAD By similarity

Sites

Active site2841Nucleophile By similarity
Binding site3821NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8Y9Y4 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 2E663708E37A0698

FASTA48853,321
        10         20         30         40         50         60 
MADVRKLKNY IDGEWVESKT DKYEDVINPA TGEVLCQVPI STRAELDQAA VIAEQAFEKW 

        70         80         90        100        110        120 
SQVAVPRRAR VLFGFQQLLI QHKEELARLI TLENGKNLSE ARGEVQRGIE NVEFAAGAPT 

       130        140        150        160        170        180 
LMMGDSLASI ATDVEAANYR YPVGVVGGIA PFNFPMMVPC WMFPMAIALG NSFILKPSER 

       190        200        210        220        230        240 
TPLLMEKLVE LFSEAGLPKG VFNVVYGAHD VVNGILENEI IKAVSFVGSK PVGEYVYKTG 

       250        260        270        280        290        300 
SANLKRVQAL TGAKNHTIVL NDADLEDTVT NVISAAFGSA GERCMACAVV TVEEGIADEF 

       310        320        330        340        350        360 
LEALRTAAQN VKIGNGLDDG VFLGPVIREE NQKRTIAYIE KGIEEGAKLT VDGRETGLSE 

       370        380        390        400        410        420 
GHFVGPTILE DVTTDMTIWK DEIFAPVLSV IRVKNLQEAV RVANQSEFAN GACIFTNNAK 

       430        440        450        460        470        480 
AIRYFREKID AGMLGVNLGV PAPMAFFPFS GWKSSFYGTL HANGKDSVDF YTHKKVVTAR 


YSLKGYEE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL591975 Genomic DNA. Translation: CAC98462.1.
PIRAH1122.
RefSeqNP_463913.1. NC_003210.1.

3D structure databases

ProteinModelPortalQ8Y9Y4.
SMRQ8Y9Y4. Positions 3-481.
ModBaseSearch...

Protein-protein interaction databases

STRING169963.lmo0383.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC98462; CAC98462; CAC98462.
GeneID987639.
KEGGlmo:lmo0383.
PATRIC20309821. VBILisMon69206_0396.

Organism-specific databases

GenoListLMO0383.

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271507.
KOK00140.
OMAVANQSEF.
ProtClustDBCLSK2460970.

Enzyme and pathway databases

BioCycLMON169963:LMO0383-MONOMER.
UniPathwayUPA00076; UER00148.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPMF_01670. IolA.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
IPR023510. MeMal-semiAld_DH_GmP_bac.
[Graphical view]
PANTHERPTHR11699:SF27. PTHR11699:SF27. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR01722. MMSDH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOLA_LISMO
AccessionPrimary (citable) accession number: Q8Y9Y4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: March 1, 2002
Last modified: May 29, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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