Shikimate dehydrogenase - Listeria monocytogenes

Preferred order of sections

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	lmo0490

Organism

Listeria monocytogenes

Taxonomic identifier

1639 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Shikimate + NADP⁺ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 291

291

Shikimate dehydrogenase HAMAP MF_00222

PRO_0000136014

Regions

Nucleotide binding

137 – 141

5

NADP By similarity

Sites

Active site

77

1

Proton acceptor Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q8Y9N5 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: BDBDFF2732CD7D5D
Show »

FASTA

291

32,161

        10         20         30         40         50         60 
MTNKITERIT GHTELIGLIA TPIRHSLSPT MHNEAFAKLG LDYVYLAFEV GDKELKDVVQ 

        70         80         90        100        110        120 
GFRAMNLRGW NVSMPNKTNI HKYLDKLSPA AELVGAVNTV VNDDGVLTGH ITDGTGYMRA 

       130        140        150        160        170        180 
LKEAGHDIIG KKMTICGAGG AATAICIQAA LDGVKEISIF NRKDDFYANA EKTVEKINSK 

       190        200        210        220        230        240 
TDCKAQLFDI EDHEQLRKEI AESVIFTNAT GVGMKPFEGE TLLPSADMLR PELIVSDVVY 

       250        260        270        280        290 
KPTKTRLLEI AEEQGCQTLN GLGMMLWQGA KAFEIWTHKE MPVDYIKEIL F

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References

[1]

"Comparative genomics of Listeria species."
Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., Dominguez-Bernal G., Duchaud E.

Cossart P.
Science 294:849-852(2001) [PubMed: 11679669] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-679 / EGD-e / Serovar 1/2a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AL591975 Genomic DNA. Translation: CAC98569.1.

PIR

AC1136.

RefSeq

NP_464018.1. NC_003210.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3TNL	X-ray	1.45	A/B/C/D	1-291	[»]
3TOZ	X-ray	2.20	A/B/C/D/E/F/G/H	1-291	[»]

ProteinModelPortal

Q8Y9N5.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

GeneID

985396.

GenomeReviews

Gene locus lmo0490 in contig AL591824_GR.

KEGG

lmo:lmo0490.

PATRIC

20310047. VBILisMon69206_0509.

Organism-specific databases

GenoList

LMO0490.

Phylogenomic databases

HOGENOM

HBG553408.

OMA

SIYIDAT.

ProtClustDB

PRK00258.

Enzyme and pathway databases

BioCyc

LMON169963:LMO0490-MONOMER.

Family and domain databases

HAMAP

MF_00222. Shikimate_DH_AroE.
[Tree]

InterPro

IPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]

Gene3D

G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.

KO

K00014.

Pfam

PF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00507. AroE. 1 hit.

ProtoNet

Search...

Entry information

Entry name

AROE_LISMO

Accession

Primary (citable) accession number: Q8Y9N5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families