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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei232 – 2321SubstrateUniRule annotation
Metal bindingi254 – 2541ZincUniRule annotation
Binding sitei254 – 2541SubstrateUniRule annotation
Metal bindingi257 – 2571ZincUniRule annotation
Binding sitei257 – 2571SubstrateUniRule annotation
Active sitei322 – 3221Proton acceptorUniRule annotation
Active sitei323 – 3231Proton acceptorUniRule annotation
Binding sitei323 – 3231SubstrateUniRule annotation
Metal bindingi356 – 3561ZincUniRule annotation
Binding sitei356 – 3561SubstrateUniRule annotation
Binding sitei410 – 4101SubstrateUniRule annotation
Metal bindingi415 – 4151ZincUniRule annotation
Binding sitei415 – 4151SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciLMON169963:LMO0567-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:lmo0567
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000817: Chromosome

Organism-specific databases

GenoListiLMO0567.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427Histidinol dehydrogenasePRO_0000135791Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo0567.

Structurei

3D structure databases

ProteinModelPortaliQ8Y9G1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ8Y9G1.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8Y9G1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILTGTINE LLNEVKAENN TNNSLQVESE VKSIIEKVKK DGDQALFDFT
60 70 80 90 100
SQFDGVRLTE LRVQTADIQS ASSKVDPAFL VALQQAKANI ESFHSKQKQH
110 120 130 140 150
AFLDSEKDGV IRGQLIRPLE TVGIYVPGGT AAYPSSVLMN VLPAKIAGVK
160 170 180 190 200
RIVMITPPAE NGINPHVLAA AQLAGVDEIY QVGGAHGIAA LAHGTESIPK
210 220 230 240 250
VDKIVGPGNI YVATAKREVF GLVDIDMIAG PSEIVVLADE NANPAFIASD
260 270 280 290 300
LLSQAEHDIL ARAILITTSK KIAEETQNEI NKQLENLPRK AIAQKSIETQ
310 320 330 340 350
GKIIIAANTQ EMFDIMNEIA PEHLEVQLEN PMNYLNQIKN AGSIFLGSYA
360 370 380 390 400
SEPLGDYFAG PNHVLPTSGT AKFFSPLGVE DFTKRSAFIS YTKEALAKEK
410 420
DAIVLLAKKE GLDAHAKAIQ IRFEEEN
Length:427
Mass (Da):46,230
Last modified:March 1, 2002 - v1
Checksum:iC7D0587C36E6E97C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591975 Genomic DNA. Translation: CAC98646.1.
PIRiAH1145.
RefSeqiNP_464095.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAC98646; CAC98646; CAC98646.
GeneIDi985596.
KEGGilmo:lmo0567.
PATRICi20310201. VBILisMon69206_0586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591975 Genomic DNA. Translation: CAC98646.1.
PIRiAH1145.
RefSeqiNP_464095.1. NC_003210.1.

3D structure databases

ProteinModelPortaliQ8Y9G1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi169963.lmo0567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC98646; CAC98646; CAC98646.
GeneIDi985596.
KEGGilmo:lmo0567.
PATRICi20310201. VBILisMon69206_0586.

Organism-specific databases

GenoListiLMO0567.

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.
PhylomeDBiQ8Y9G1.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciLMON169963:LMO0567-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiHISX_LISMO
AccessioniPrimary (citable) accession number: Q8Y9G1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2002
Last modified: January 7, 2015
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.