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Q8Y915

- GLMS_LISMO

UniProt

Q8Y915 - GLMS_LISMO

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Protein
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
glmS, lmo0727
Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei596 – 5961For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciLMON169963:LMO0727-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:lmo0727
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000817: Chromosome

Organism-specific databases

GenoListiLMO0727.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 601600Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation
PRO_0000135353Add
BLAST

PTM databases

PhosSiteiP11111108.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi169963.lmo0727.

Structurei

3D structure databases

ProteinModelPortaliQ8Y915.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 216215Glutamine amidotransferase type-2
Add
BLAST
Domaini282 – 421140SIS 1
Add
BLAST
Domaini453 – 591139SIS 2
Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.
PhylomeDBiQ8Y915.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8Y915-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIVGYIGT NNAKGILLEG LEKLEYRGYD SAGIALQNKE LVTVVKEKGR    50
IADLASLVPS DAFGTTGIGH TRWATHGKPN HENAHPHQSK SGRFTIVHNG 100
VIENYTLLKE EYLKNHSFVS DTDTEVIVQL IELFAAELST KEAFKKALSL 150
LHGSYAICLI DQTNTETLYA AKNKSPLLIG KGENFNVIAS DAMAVLKETD 200
EFVEIMDKEI VIVTKDGFTL ETLEGEEITR ASYKAELDAS DIEKGTYPHY 250
MLKEIDEQPA VTRKIIQAYQ DEAGEINVDK TIIDEILSSD RIHIVACGTS 300
YHAGLVGKNL IEKMAKIPVE VHVSSEFAYN LPLMSKKPLF IFITQSGETA 350
DSRQCLVKVK ELGYRTLTLT NVPGSTLDRE ADHSMYLYAG PEIAVASTKA 400
YTAQISVLAV LAVSLGREIG DEEALNINLA AELGIVATAM EAMVSSKEVI 450
EHIAGEYLAT SRNAFFLGRN IDYFVAMEAA LKLKEISYIQ AEGFASGELK 500
HGTIALIEDG TPVLALITQE SINWNIRGNV NEVLARGAKT CIFAMENVAQ 550
PGDRFVIPQV HPLLTPLASV IPCQLLAYYA ALHRDCDVDK PRNLAKSVTV 600
E 601
Length:601
Mass (Da):65,767
Last modified:January 23, 2007 - v3
Checksum:iCE9182743475C273
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591976 Genomic DNA. Translation: CAC98805.1.
PIRiAG1165.
RefSeqiNP_464254.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAC98805; CAC98805; CAC98805.
GeneIDi986353.
KEGGilmo:lmo0727.
PATRICi20310529. VBILisMon69206_0749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591976 Genomic DNA. Translation: CAC98805.1 .
PIRi AG1165.
RefSeqi NP_464254.1. NC_003210.1.

3D structure databases

ProteinModelPortali Q8Y915.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 169963.lmo0727.

PTM databases

PhosSitei P11111108.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC98805 ; CAC98805 ; CAC98805 .
GeneIDi 986353.
KEGGi lmo:lmo0727.
PATRICi 20310529. VBILisMon69206_0749.

Organism-specific databases

GenoListi LMO0727.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.
PhylomeDBi Q8Y915.

Enzyme and pathway databases

BioCyci LMON169963:LMO0727-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiGLMS_LISMO
AccessioniPrimary (citable) accession number: Q8Y915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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