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Q8Y915

- GLMS_LISMO

UniProt

Q8Y915 - GLMS_LISMO

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei596 – 5961For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciLMON169963:LMO0727-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:lmo0727
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000817: Chromosome

Organism-specific databases

GenoListiLMO0727.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 601600Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135353Add
BLAST

PTM databases

PhosSiteiP11111108.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi169963.lmo0727.

Structurei

3D structure databases

ProteinModelPortaliQ8Y915.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 216215Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini282 – 421140SIS 1UniRule annotationAdd
BLAST
Domaini453 – 591139SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.
PhylomeDBiQ8Y915.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8Y915-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGYIGT NNAKGILLEG LEKLEYRGYD SAGIALQNKE LVTVVKEKGR
60 70 80 90 100
IADLASLVPS DAFGTTGIGH TRWATHGKPN HENAHPHQSK SGRFTIVHNG
110 120 130 140 150
VIENYTLLKE EYLKNHSFVS DTDTEVIVQL IELFAAELST KEAFKKALSL
160 170 180 190 200
LHGSYAICLI DQTNTETLYA AKNKSPLLIG KGENFNVIAS DAMAVLKETD
210 220 230 240 250
EFVEIMDKEI VIVTKDGFTL ETLEGEEITR ASYKAELDAS DIEKGTYPHY
260 270 280 290 300
MLKEIDEQPA VTRKIIQAYQ DEAGEINVDK TIIDEILSSD RIHIVACGTS
310 320 330 340 350
YHAGLVGKNL IEKMAKIPVE VHVSSEFAYN LPLMSKKPLF IFITQSGETA
360 370 380 390 400
DSRQCLVKVK ELGYRTLTLT NVPGSTLDRE ADHSMYLYAG PEIAVASTKA
410 420 430 440 450
YTAQISVLAV LAVSLGREIG DEEALNINLA AELGIVATAM EAMVSSKEVI
460 470 480 490 500
EHIAGEYLAT SRNAFFLGRN IDYFVAMEAA LKLKEISYIQ AEGFASGELK
510 520 530 540 550
HGTIALIEDG TPVLALITQE SINWNIRGNV NEVLARGAKT CIFAMENVAQ
560 570 580 590 600
PGDRFVIPQV HPLLTPLASV IPCQLLAYYA ALHRDCDVDK PRNLAKSVTV

E
Length:601
Mass (Da):65,767
Last modified:January 23, 2007 - v3
Checksum:iCE9182743475C273
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591976 Genomic DNA. Translation: CAC98805.1.
PIRiAG1165.
RefSeqiNP_464254.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAC98805; CAC98805; CAC98805.
GeneIDi986353.
KEGGilmo:lmo0727.
PATRICi20310529. VBILisMon69206_0749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591976 Genomic DNA. Translation: CAC98805.1 .
PIRi AG1165.
RefSeqi NP_464254.1. NC_003210.1.

3D structure databases

ProteinModelPortali Q8Y915.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 169963.lmo0727.

Protein family/group databases

MEROPSi C44.971.

PTM databases

PhosSitei P11111108.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC98805 ; CAC98805 ; CAC98805 .
GeneIDi 986353.
KEGGi lmo:lmo0727.
PATRICi 20310529. VBILisMon69206_0749.

Organism-specific databases

GenoListi LMO0727.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.
PhylomeDBi Q8Y915.

Enzyme and pathway databases

BioCyci LMON169963:LMO0727-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiGLMS_LISMO
AccessioniPrimary (citable) accession number: Q8Y915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3