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Q8Y915

- GLMS_LISMO

UniProt

Q8Y915 - GLMS_LISMO

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei596 – 5961For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciLMON169963:LMO0727-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:lmo0727
    OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
    Taxonomic identifieri169963 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000000817: Chromosome

    Organism-specific databases

    GenoListiLMO0727.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 601600Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135353Add
    BLAST

    PTM databases

    PhosSiteiP11111108.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi169963.lmo0727.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8Y915.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 216215Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini282 – 421140SIS 1UniRule annotationAdd
    BLAST
    Domaini453 – 591139SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiPVTRRFM.
    OrthoDBiEOG6KT2Q1.
    PhylomeDBiQ8Y915.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8Y915-1 [UniParc]FASTAAdd to Basket

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    MCGIVGYIGT NNAKGILLEG LEKLEYRGYD SAGIALQNKE LVTVVKEKGR    50
    IADLASLVPS DAFGTTGIGH TRWATHGKPN HENAHPHQSK SGRFTIVHNG 100
    VIENYTLLKE EYLKNHSFVS DTDTEVIVQL IELFAAELST KEAFKKALSL 150
    LHGSYAICLI DQTNTETLYA AKNKSPLLIG KGENFNVIAS DAMAVLKETD 200
    EFVEIMDKEI VIVTKDGFTL ETLEGEEITR ASYKAELDAS DIEKGTYPHY 250
    MLKEIDEQPA VTRKIIQAYQ DEAGEINVDK TIIDEILSSD RIHIVACGTS 300
    YHAGLVGKNL IEKMAKIPVE VHVSSEFAYN LPLMSKKPLF IFITQSGETA 350
    DSRQCLVKVK ELGYRTLTLT NVPGSTLDRE ADHSMYLYAG PEIAVASTKA 400
    YTAQISVLAV LAVSLGREIG DEEALNINLA AELGIVATAM EAMVSSKEVI 450
    EHIAGEYLAT SRNAFFLGRN IDYFVAMEAA LKLKEISYIQ AEGFASGELK 500
    HGTIALIEDG TPVLALITQE SINWNIRGNV NEVLARGAKT CIFAMENVAQ 550
    PGDRFVIPQV HPLLTPLASV IPCQLLAYYA ALHRDCDVDK PRNLAKSVTV 600
    E 601
    Length:601
    Mass (Da):65,767
    Last modified:January 23, 2007 - v3
    Checksum:iCE9182743475C273
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591976 Genomic DNA. Translation: CAC98805.1.
    PIRiAG1165.
    RefSeqiNP_464254.1. NC_003210.1.

    Genome annotation databases

    EnsemblBacteriaiCAC98805; CAC98805; CAC98805.
    GeneIDi986353.
    KEGGilmo:lmo0727.
    PATRICi20310529. VBILisMon69206_0749.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591976 Genomic DNA. Translation: CAC98805.1 .
    PIRi AG1165.
    RefSeqi NP_464254.1. NC_003210.1.

    3D structure databases

    ProteinModelPortali Q8Y915.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 169963.lmo0727.

    PTM databases

    PhosSitei P11111108.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC98805 ; CAC98805 ; CAC98805 .
    GeneIDi 986353.
    KEGGi lmo:lmo0727.
    PATRICi 20310529. VBILisMon69206_0749.

    Organism-specific databases

    GenoListi LMO0727.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi PVTRRFM.
    OrthoDBi EOG6KT2Q1.
    PhylomeDBi Q8Y915.

    Enzyme and pathway databases

    BioCyci LMON169963:LMO0727-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-679 / EGD-e.

    Entry informationi

    Entry nameiGLMS_LISMO
    AccessioniPrimary (citable) accession number: Q8Y915
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 79 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3