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Protein

Uracil-DNA glycosylase 2

Gene

ung2

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylase 2UniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDG 2UniRule annotation
Gene namesi
Name:ung2UniRule annotation
Ordered Locus Names:lmo1227
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001761141 – 224Uracil-DNA glycosylase 2Add BLAST224

Proteomic databases

PaxDbiQ8Y7P6.

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo1227.

Structurei

3D structure databases

ProteinModelPortaliQ8Y7P6.
SMRiQ8Y7P6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5S. Bacteria.
COG0692. LUCA.
HOGENOMiHOG000229528.
KOiK03648.
OMAiQANGLCF.
PhylomeDBiQ8Y7P6.

Family and domain databases

CDDicd10027. UDG_F1. 1 hit.
Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG. 1 hit.
InterProiView protein in InterPro
IPR002043. UDG_fam1.
IPR018085. Ura-DNA_Glyclase_AS.
IPR005122. Uracil-DNA_glycosylase-like.
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiView protein in Pfam
PF03167. UDG. 1 hit.
SMARTiView protein in SMART
SM00986. UDG. 1 hit.
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiView protein in PROSITE
PS00130. U_DNA_GLYCOSYLASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8Y7P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKLGNDWDE LLKNEFNQPY YLTLRQFLKK EYQTKKVFPD MYDIFNALKH
60 70 80 90 100
TAYKDVKVVI LGQDPYHGPG QAHGLSFSVQ QGVQIPPSLQ NIYLELHNDL
110 120 130 140 150
NCEIPNNGYL IPWADQGVLL LNTVLTVRAG QANSHRGQGW EILTNHIIEI
160 170 180 190 200
INQKEEPVVF LLWGSNAKEK LQLLTNPKHT AFTSVHPSPL SASRGFMGCK
210 220
HFSKTNQFLE QNGVKPIDWQ IPSI
Length:224
Mass (Da):25,562
Last modified:March 1, 2002 - v1
Checksum:i1610F811E552431D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591978 Genomic DNA. Translation: CAC99305.1.
PIRiAC1228.
RefSeqiNP_464752.1. NC_003210.1.
WP_003732773.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAC99305; CAC99305; CAC99305.
GeneIDi986857.
KEGGilmo:lmo1227.
PATRICifig|169963.11.peg.1258.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiUNG2_LISMO
AccessioniPrimary (citable) accession number: Q8Y7P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2002
Last modified: July 5, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families