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Protein

Uracil-DNA glycosylase 2

Gene

ung2

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BioCyciLMON169963:LMO1227-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylase 2UniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDG 2UniRule annotation
Gene namesi
Name:ung2UniRule annotation
Ordered Locus Names:lmo1227
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Uracil-DNA glycosylase 2PRO_0000176114Add
BLAST

Proteomic databases

PaxDbiQ8Y7P6.

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo1227.

Structurei

3D structure databases

ProteinModelPortaliQ8Y7P6.
SMRiQ8Y7P6. Positions 7-223.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5S. Bacteria.
COG0692. LUCA.
HOGENOMiHOG000229528.
KOiK03648.
OMAiIALIPKN.
OrthoDBiEOG6MSS63.
PhylomeDBiQ8Y7P6.

Family and domain databases

Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG.
InterProiIPR018085. Ura-DNA_Glyclase_AS.
IPR002043. Ura_DNA_glycsylse.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8Y7P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKLGNDWDE LLKNEFNQPY YLTLRQFLKK EYQTKKVFPD MYDIFNALKH
60 70 80 90 100
TAYKDVKVVI LGQDPYHGPG QAHGLSFSVQ QGVQIPPSLQ NIYLELHNDL
110 120 130 140 150
NCEIPNNGYL IPWADQGVLL LNTVLTVRAG QANSHRGQGW EILTNHIIEI
160 170 180 190 200
INQKEEPVVF LLWGSNAKEK LQLLTNPKHT AFTSVHPSPL SASRGFMGCK
210 220
HFSKTNQFLE QNGVKPIDWQ IPSI
Length:224
Mass (Da):25,562
Last modified:March 1, 2002 - v1
Checksum:i1610F811E552431D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591978 Genomic DNA. Translation: CAC99305.1.
PIRiAC1228.
RefSeqiNP_464752.1. NC_003210.1.
WP_003732773.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAC99305; CAC99305; CAC99305.
GeneIDi986857.
KEGGilmo:lmo1227.
PATRICi20311561. VBILisMon69206_1258.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591978 Genomic DNA. Translation: CAC99305.1.
PIRiAC1228.
RefSeqiNP_464752.1. NC_003210.1.
WP_003732773.1. NC_003210.1.

3D structure databases

ProteinModelPortaliQ8Y7P6.
SMRiQ8Y7P6. Positions 7-223.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi169963.lmo1227.

Proteomic databases

PaxDbiQ8Y7P6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC99305; CAC99305; CAC99305.
GeneIDi986857.
KEGGilmo:lmo1227.
PATRICi20311561. VBILisMon69206_1258.

Phylogenomic databases

eggNOGiENOG4105D5S. Bacteria.
COG0692. LUCA.
HOGENOMiHOG000229528.
KOiK03648.
OMAiIALIPKN.
OrthoDBiEOG6MSS63.
PhylomeDBiQ8Y7P6.

Enzyme and pathway databases

BioCyciLMON169963:LMO1227-MONOMER.

Family and domain databases

Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG.
InterProiIPR018085. Ura-DNA_Glyclase_AS.
IPR002043. Ura_DNA_glycsylse.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiUNG2_LISMO
AccessioniPrimary (citable) accession number: Q8Y7P6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2002
Last modified: February 17, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.