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Q8Y7I9 (LUXS_LISMO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
S-ribosylhomocysteine lyase

EC=4.4.1.21
Alternative name(s):
AI-2 synthesis protein
Autoinducer-2 production protein LuxS
Gene names
Name:luxS
Ordered Locus Names:lmo1288
OrganismListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) [Reference proteome] [HAMAP]
Taxonomic identifier169963 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length155 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity. HAMAP-Rule MF_00091

Catalytic activity

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. HAMAP-Rule MF_00091

Cofactor

Binds 1 iron ion per subunit By similarity. HAMAP-Rule MF_00091

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00091

Sequence similarities

Belongs to the LuxS family.

Ontologies

Keywords
   Biological processAutoinducer synthesis
Quorum sensing
   LigandIron
Metal-binding
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processbiofilm formation

Inferred from mutant phenotype PubMed 16885324. Source: CACAO

quorum sensing

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionS-ribosylhomocysteine lyase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 155155S-ribosylhomocysteine lyase HAMAP-Rule MF_00091
PRO_0000172237

Sites

Metal binding571Iron By similarity
Metal binding611Iron By similarity
Metal binding1241Iron By similarity

Experimental info

Sequence conflict1311S → R in AAM48492. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8Y7I9 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: EC7003D5C9F22248

FASTA15517,368
        10         20         30         40         50         60 
MAEKMNVESF NLDHTKVKAP FVRLAGTKVG VHGDEIYKYD VRFKQPNKEH MEMPALHSLE 

        70         80         90        100        110        120 
HLMAELARNH TDKLVDISPM GCQTGFYVSF INHSDYDDAL EIIATTLTDV LVATEVPACN 

       130        140        150 
EVQCGWAASH SLEGAKALAE EFLAKRSEWK NVFGE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF084044 Genomic DNA. Translation: AAM48492.1.
AL591978 Genomic DNA. Translation: CAC99366.1.
PIRAH1235.
RefSeqNP_464813.1. NC_003210.1.

3D structure databases

ProteinModelPortalQ8Y7I9.
SMRQ8Y7I9. Positions 4-152.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING169963.lmo1288.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC99366; CAC99366; CAC99366.
GeneID987285.
KEGGlmo:lmo1288.
PATRIC20311693. VBILisMon69206_1323.

Organism-specific databases

GenoListLMO1288.

Phylogenomic databases

eggNOGCOG1854.
HOGENOMHOG000040372.
KOK07173.
OMALTKYDVR.
OrthoDBEOG68WRBM.
ProtClustDBPRK02260.

Enzyme and pathway databases

BioCycLMON169963:LMO1288-MONOMER.

Family and domain databases

Gene3D3.30.1360.80. 1 hit.
HAMAPMF_00091. LuxS.
InterProIPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view]
PfamPF02664. LuxS. 1 hit.
[Graphical view]
PIRSFPIRSF006160. AI2. 1 hit.
PRINTSPR01487. LUXSPROTEIN.
ProDomPD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF63411. SSF63411. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLUXS_LISMO
AccessionPrimary (citable) accession number: Q8Y7I9
Secondary accession number(s): Q8KYA8
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families