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Protein

LexA repressor

Gene

lexA

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.UniRule annotation

Catalytic activityi

Hydrolysis of Ala-|-Gly bond in repressor LexA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei126For autocatalytic cleavage activityUniRule annotation1
Active sitei164For autocatalytic cleavage activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi27 – 47H-T-H motifUniRule annotationAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Hydrolase, Repressor
Biological processDNA damage, DNA repair, DNA replication, SOS response, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciLMON169963:LMO1302-MONOMER

Protein family/group databases

MEROPSiS24.001

Names & Taxonomyi

Protein namesi
Recommended name:
LexA repressorUniRule annotation (EC:3.4.21.88UniRule annotation)
Gene namesi
Name:lexAUniRule annotation
Ordered Locus Names:lmo1302
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001700531 – 204LexA repressorAdd BLAST204

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei90 – 91Cleavage; by autolysisUniRule annotation2

Keywords - PTMi

Autocatalytic cleavage

Proteomic databases

PaxDbiQ8Y7H7

Expressioni

Gene expression databases

CollecTFiEXPREG_000013e0

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi169963.lmo1302

Structurei

3D structure databases

ProteinModelPortaliQ8Y7H7
SMRiQ8Y7H7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S24 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DS7 Bacteria
COG1974 LUCA
HOGENOMiHOG000232168
KOiK01356
OMAiRQMMQAM
PhylomeDBiQ8Y7H7

Family and domain databases

CDDicd00090 HTH_ARSR, 1 hit
Gene3Di1.10.10.10, 1 hit
HAMAPiMF_00015 LexA, 1 hit
InterProiView protein in InterPro
IPR011991 ArsR-like_HTH
IPR006200 LexA
IPR036286 LexA/Signal_pep-like_sf
IPR006199 LexA_DNA-bd_dom
IPR006197 Peptidase_S24_LexA
IPR015927 Peptidase_S24_S26A/B/C
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01726 LexA_DNA_bind, 1 hit
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00726 LEXASERPTASE
SUPFAMiSSF46785 SSF46785, 1 hit
SSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR00498 lexA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Y7H7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKISKRQQDI YEFIKSEVKE KGYPPSVREI GEAVGLASSS TVHGHLARLE
60 70 80 90 100
GKGLIRRDPT KPRAIEILSL EDEAETPNVV NIPIIGKVTA GMPITAIENI
110 120 130 140 150
DEYFPLPEYM AAGETNVFML EIDGESMINA GILDGDKVIV RQESSAINGE
160 170 180 190 200
IVVAMTDENE ATCKRFYKEA NHFRLQPEND ALEPILLNNV TILGKVIGLY

RDIR
Length:204
Mass (Da):22,638
Last modified:March 1, 2002 - v1
Checksum:i05DBADBEC089F313
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591978 Genomic DNA Translation: CAC99380.1
PIRiAF1237
RefSeqiNP_464827.1, NC_003210.1
WP_009930693.1, NC_003210.1

Genome annotation databases

EnsemblBacteriaiCAC99380; CAC99380; CAC99380
GeneIDi985139
KEGGilmo:lmo1302
PATRICifig|169963.11.peg.1338

Similar proteinsi

Entry informationi

Entry nameiLEXA_LISMO
AccessioniPrimary (citable) accession number: Q8Y7H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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