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Q8Y7F1

- PNP_LISMO

UniProt

Q8Y7F1 - PNP_LISMO

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi488 – 4881MagnesiumUniRule annotation
Metal bindingi494 – 4941MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciLMON169963:LMO1331-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:lmo1331
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000817: Chromosome

Organism-specific databases

GenoListiLMO1331.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 723723Polyribonucleotide nucleotidyltransferasePRO_0000329702Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo1331.

Structurei

3D structure databases

ProteinModelPortaliQ8Y7F1.
SMRiQ8Y7F1. Positions 620-692.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 61460KHUniRule annotationAdd
BLAST
Domaini624 – 69269S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.
PhylomeDBiQ8Y7F1.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8Y7F1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEKQVFSTE WAGKTLSVEV GQLAKQASGA ALIRYGDTVV LTAAVGSKKP
60 70 80 90 100
RPGDFFPLTV NYEEKMYSVG KVPGGFLKRE GRPSDRATLT ARLIDRPIRP
110 120 130 140 150
LFAEGFRNEV QITSTVFSVD QDCSPEMAAM LGSSVALVIS DIPFEGPIAG
160 170 180 190 200
VDVGRIDGKY VINPTIEQAE KSDISLTVAG TYDAINMVEA GAKEVSEEAM
210 220 230 240 250
LEAIMFGHEE IKRLCEFQQQ IIAAVGKEKR EIELFVSDPE LEAEVKAASE
260 270 280 290 300
GKMKTAIKTE EKKAREAAIE EVKEEILESY KAKELENESE ILSEVAHILE
310 320 330 340 350
MIEKDEMRRL ISQDKIRPDG RKVNEIRPLS SEVGMLPRVH GSGLFTRGQT
360 370 380 390 400
QALSVCTLAP LREHQIIDGL GTEEYKRFMH HYNFPQFSVG ETGPRRAPGR
410 420 430 440 450
REIGHGALGE RALQYVIPSE EEFPYTIRLV SEVLESNGSS SQASICGSTL
460 470 480 490 500
AMLDAGVPIK APVAGIAMGL VKLGDDYTIL SDIQGMEDHF GDMDFKVAGT
510 520 530 540 550
KDGITALQMD IKIDGLSRQI LDEALTQAKE GRLHILEHLT STISAPREEL
560 570 580 590 600
SAYAPKIITL NIKPEKIKDV IGPGGKQINA IIDETGVKID IEQDGTVYIA
610 620 630 640 650
SQDQAMNRKA IAIIEDIVRE VEVGEVYTGK VRRIEKFGAF VELFKGTDGL
660 670 680 690 700
VHISELAHER VGKVEDILKL GDEVTVKVIE VDQQGRVNLS RKALLEKKEQ
710 720
PEGDKKPQAE KKFYPKTKKP ESK
Length:723
Mass (Da):79,602
Last modified:March 1, 2002 - v1
Checksum:iC33F64C47EFD9EBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591978 Genomic DNA. Translation: CAC99409.1.
PIRiAC1241.
RefSeqiNP_464856.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAC99409; CAC99409; CAC99409.
GeneIDi987712.
KEGGilmo:lmo1331.
PATRICi20311783. VBILisMon69206_1368.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591978 Genomic DNA. Translation: CAC99409.1 .
PIRi AC1241.
RefSeqi NP_464856.1. NC_003210.1.

3D structure databases

ProteinModelPortali Q8Y7F1.
SMRi Q8Y7F1. Positions 620-692.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 169963.lmo1331.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC99409 ; CAC99409 ; CAC99409 .
GeneIDi 987712.
KEGGi lmo:lmo1331.
PATRICi 20311783. VBILisMon69206_1368.

Organism-specific databases

GenoListi LMO1331.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.
PhylomeDBi Q8Y7F1.

Enzyme and pathway databases

BioCyci LMON169963:LMO1331-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiPNP_LISMO
AccessioniPrimary (citable) accession number: Q8Y7F1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3