Q8Y7D5 (GCST_LISMO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	lmo1348

Organism

Listeria monocytogenes

Taxonomic identifier

1639 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Aminomethyltransferase HAMAP MF_00259		PRO_0000122569

Sequences

	Sequence		Length	Mass (Da)
	Q8Y7D5 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 02388A0C6D3B9600	FASTA	362	39,535
	10 20 30 40 50 60 MTELLKTPIH PLYAKYGAKT IDFGGWDLPV QFAGIKAEHE AVRTDAGLFD VSHMGEILVK 70 80 90 100 110 120 GPDSTSYLQY LLSNDIEKIK IGKAQYNIMC YETGGTVDDL VVYKKSETEY ILVVNAANTD 130 140 150 160 170 180 KDFEWMVKNI RGDVSVTNVS SEYGQLALQG PNAEKILSKL TDVDLSSISF FGFVEDADVA 190 200 210 220 230 240 GVKTIISRSG YTGEDGFEIY MPSADAGKVF EAILAEGVAP IGLGARDTLR LEAVLALYGQ 250 260 270 280 290 300 ELSKDITPLE AGLNFAVKLK KEADFIGKEA LIKQKEAGLN RKLVGIELIE RGIPRHDYPV 310 320 330 340 350 360 FLNEEQIGVV TSGTQSPTLG INIGLALIDT AYTELGQEVE VGIRNKKVKA KIVPTPFYKR AK

References

[1]

"Comparative genomics of Listeria species." Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., Dominguez-Bernal G., Duchaud E. , Durant L., Dussurget O., Entian K.-D., Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W., Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U., Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A., Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P. Science 294:849-852(2001) [PubMed: 11679669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-679 / EGD-e / Serovar 1/2a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL591978 Genomic DNA. Translation: CAC99426.1.
PIR	AD1243.
RefSeq	NP_464873.1. NC_003210.1.
3D structure databases
ProteinModelPortal	Q8Y7D5.
SMR	Q8Y7D5. Positions 4-357.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	987736.
GenomeReviews	Gene locus lmo1348 in contig AL591824_GR.
KEGG	lmo:lmo1348.
PATRIC	20311817. VBILisMon69206_1385.
Organism-specific databases
GenoList	LMO1348.
Phylogenomic databases
HOGENOM	HBG299834.
OMA	MVKNIRG.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	LMON169963:LMO1348-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_LISMO

Accession

Primary (citable) accession number: Q8Y7D5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program