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Q8Y7D3 (GCSPB_LISMO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene names
Name:gcvPB
Ordered Locus Names:lmo1350
OrganismListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) [Reference proteome] [HAMAP]
Taxonomic identifier169963 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00713

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00713

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00713

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. C-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Probable glycine dehydrogenase (decarboxylating) subunit 2 HAMAP-Rule MF_00713
PRO_0000167007

Amino acid modifications

Modified residue2741N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8Y7D3 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: E2C8A3BB619EB081

FASTA48854,198
        10         20         30         40         50         60 
MNLEETMPLV FERSIPGRIG FSLPESDVPE TNAGDYFDQA YIRSIPADLP ELSELEIMRH 

        70         80         90        100        110        120 
YTNLSNHNFG VDSGFYPLGS CTMKYNPKIN EKVARFPGFA NIHPNQPESS VQGALELLYD 

       130        140        150        160        170        180 
LQTSLVEITG MDEVTLQPAA GAHGEWTGLM LIRAFHEKNG DTKRTKVIIP DSAHGTNPAS 

       190        200        210        220        230        240 
AAVAGFDVVT VKSNEKGLVD VADLKKVVGE DTAALMLTNP NTLGLFEKDI VEMAEIVHEA 

       250        260        270        280        290        300 
GGKLYYDGAN LNAIMAKVRP GDMGFDVVHL NLHKTFTGPH GGGGPGSGPI GVKKELIPFL 

       310        320        330        340        350        360 
PTPVLTKKED IYTFDYNYPD SIGRVKPYYG NFGINVRAYT YIRTMGPDGL KLVTEYAVLN 

       370        380        390        400        410        420 
ANYMMRKLQE AYDLPFDQVC KHEFVLSGNR QKKLGVRTVD IAKRLLDHNF HPPTVYFPLI 

       430        440        450        460        470        480 
VGEAIMIEPT ETESKETLDS FIDTMLKIAK EAEENPEIVQ EAPHSTYVKR LDETRAARKP 


ILRYQKEV 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591978 Genomic DNA. Translation: CAC99428.1.
PIRAF1243.
RefSeqNP_464875.1. NC_003210.1.

3D structure databases

ProteinModelPortalQ8Y7D3.
SMRQ8Y7D3. Positions 6-486.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING169963.lmo1350.

PTM databases

PhosSiteP11111107.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC99428; CAC99428; CAC99428.
GeneID987740.
KEGGlmo:lmo1350.
PATRIC20311821. VBILisMon69206_1387.

Organism-specific databases

GenoListLMO1350.

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239368.
KOK00283.
OMAWTGLMMI.
OrthoDBEOG6HMXDX.
PhylomeDBQ8Y7D3.

Enzyme and pathway databases

BioCycLMON169963:LMO1350-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00713. GcvPB.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPB_LISMO
AccessionPrimary (citable) accession number: Q8Y7D3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families