Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8Y7D3

- GCSPB_LISMO

UniProt

Q8Y7D3 - GCSPB_LISMO

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciLMON169963:LMO1350-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:lmo1350
    OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
    Taxonomic identifieri169963 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000000817: Chromosome

    Organism-specific databases

    GenoListiLMO1350.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_0000167007Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei274 – 2741N6-(pyridoxal phosphate)lysineUniRule annotation

    PTM databases

    PhosSiteiP11111107.

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi169963.lmo1350.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8Y7D3.
    SMRiQ8Y7D3. Positions 6-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239368.
    KOiK00283.
    OMAiWTGLMMI.
    OrthoDBiEOG6HMXDX.
    PhylomeDBiQ8Y7D3.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8Y7D3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLEETMPLV FERSIPGRIG FSLPESDVPE TNAGDYFDQA YIRSIPADLP    50
    ELSELEIMRH YTNLSNHNFG VDSGFYPLGS CTMKYNPKIN EKVARFPGFA 100
    NIHPNQPESS VQGALELLYD LQTSLVEITG MDEVTLQPAA GAHGEWTGLM 150
    LIRAFHEKNG DTKRTKVIIP DSAHGTNPAS AAVAGFDVVT VKSNEKGLVD 200
    VADLKKVVGE DTAALMLTNP NTLGLFEKDI VEMAEIVHEA GGKLYYDGAN 250
    LNAIMAKVRP GDMGFDVVHL NLHKTFTGPH GGGGPGSGPI GVKKELIPFL 300
    PTPVLTKKED IYTFDYNYPD SIGRVKPYYG NFGINVRAYT YIRTMGPDGL 350
    KLVTEYAVLN ANYMMRKLQE AYDLPFDQVC KHEFVLSGNR QKKLGVRTVD 400
    IAKRLLDHNF HPPTVYFPLI VGEAIMIEPT ETESKETLDS FIDTMLKIAK 450
    EAEENPEIVQ EAPHSTYVKR LDETRAARKP ILRYQKEV 488
    Length:488
    Mass (Da):54,198
    Last modified:March 1, 2002 - v1
    Checksum:iE2C8A3BB619EB081
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591978 Genomic DNA. Translation: CAC99428.1.
    PIRiAF1243.
    RefSeqiNP_464875.1. NC_003210.1.

    Genome annotation databases

    EnsemblBacteriaiCAC99428; CAC99428; CAC99428.
    GeneIDi987740.
    KEGGilmo:lmo1350.
    PATRICi20311821. VBILisMon69206_1387.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591978 Genomic DNA. Translation: CAC99428.1 .
    PIRi AF1243.
    RefSeqi NP_464875.1. NC_003210.1.

    3D structure databases

    ProteinModelPortali Q8Y7D3.
    SMRi Q8Y7D3. Positions 6-486.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 169963.lmo1350.

    PTM databases

    PhosSitei P11111107.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC99428 ; CAC99428 ; CAC99428 .
    GeneIDi 987740.
    KEGGi lmo:lmo1350.
    PATRICi 20311821. VBILisMon69206_1387.

    Organism-specific databases

    GenoListi LMO1350.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239368.
    KOi K00283.
    OMAi WTGLMMI.
    OrthoDBi EOG6HMXDX.
    PhylomeDBi Q8Y7D3.

    Enzyme and pathway databases

    BioCyci LMON169963:LMO1350-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-679 / EGD-e.

    Entry informationi

    Entry nameiGCSPB_LISMO
    AccessioniPrimary (citable) accession number: Q8Y7D3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3