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Q8Y7D3

- GCSPB_LISMO

UniProt

Q8Y7D3 - GCSPB_LISMO

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, lmo1350
Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciLMON169963:LMO1350-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:lmo1350
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000817: Chromosome

Organism-specific databases

GenoListiLMO1350.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_0000167007Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei274 – 2741N6-(pyridoxal phosphate)lysine By similarity

PTM databases

PhosSiteiP11111107.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi169963.lmo1350.

Structurei

3D structure databases

ProteinModelPortaliQ8Y7D3.
SMRiQ8Y7D3. Positions 6-486.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.
PhylomeDBiQ8Y7D3.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8Y7D3-1 [UniParc]FASTAAdd to Basket

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MNLEETMPLV FERSIPGRIG FSLPESDVPE TNAGDYFDQA YIRSIPADLP    50
ELSELEIMRH YTNLSNHNFG VDSGFYPLGS CTMKYNPKIN EKVARFPGFA 100
NIHPNQPESS VQGALELLYD LQTSLVEITG MDEVTLQPAA GAHGEWTGLM 150
LIRAFHEKNG DTKRTKVIIP DSAHGTNPAS AAVAGFDVVT VKSNEKGLVD 200
VADLKKVVGE DTAALMLTNP NTLGLFEKDI VEMAEIVHEA GGKLYYDGAN 250
LNAIMAKVRP GDMGFDVVHL NLHKTFTGPH GGGGPGSGPI GVKKELIPFL 300
PTPVLTKKED IYTFDYNYPD SIGRVKPYYG NFGINVRAYT YIRTMGPDGL 350
KLVTEYAVLN ANYMMRKLQE AYDLPFDQVC KHEFVLSGNR QKKLGVRTVD 400
IAKRLLDHNF HPPTVYFPLI VGEAIMIEPT ETESKETLDS FIDTMLKIAK 450
EAEENPEIVQ EAPHSTYVKR LDETRAARKP ILRYQKEV 488
Length:488
Mass (Da):54,198
Last modified:March 1, 2002 - v1
Checksum:iE2C8A3BB619EB081
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591978 Genomic DNA. Translation: CAC99428.1.
PIRiAF1243.
RefSeqiNP_464875.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAC99428; CAC99428; CAC99428.
GeneIDi987740.
KEGGilmo:lmo1350.
PATRICi20311821. VBILisMon69206_1387.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591978 Genomic DNA. Translation: CAC99428.1 .
PIRi AF1243.
RefSeqi NP_464875.1. NC_003210.1.

3D structure databases

ProteinModelPortali Q8Y7D3.
SMRi Q8Y7D3. Positions 6-486.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 169963.lmo1350.

PTM databases

PhosSitei P11111107.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC99428 ; CAC99428 ; CAC99428 .
GeneIDi 987740.
KEGGi lmo:lmo1350.
PATRICi 20311821. VBILisMon69206_1387.

Organism-specific databases

GenoListi LMO1350.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.
PhylomeDBi Q8Y7D3.

Enzyme and pathway databases

BioCyci LMON169963:LMO1350-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiGCSPB_LISMO
AccessioniPrimary (citable) accession number: Q8Y7D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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