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Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei170 – 1701UniRule annotation
Active sitei220 – 2201Proton donorUniRule annotation
Active sitei290 – 2901UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciLMON169963:LMO1420-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation (EC:1.3.1.98UniRule annotation)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenaseUniRule annotation
Gene namesi
Name:murBUniRule annotation
Ordered Locus Names:lmo1420
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298UDP-N-acetylenolpyruvoylglucosamine reductasePRO_0000179227Add
BLAST

Proteomic databases

PaxDbiQ8Y776.

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo1420.

Structurei

Secondary structure

1
298
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 74Combined sources
Beta strandi11 – 188Combined sources
Helixi19 – 224Combined sources
Beta strandi30 – 367Combined sources
Helixi40 – 5213Combined sources
Beta strandi57 – 615Combined sources
Beta strandi66 – 683Combined sources
Beta strandi73 – 797Combined sources
Beta strandi86 – 894Combined sources
Beta strandi92 – 965Combined sources
Helixi101 – 11010Combined sources
Beta strandi113 – 1153Combined sources
Helixi117 – 1193Combined sources
Helixi126 – 1327Combined sources
Helixi141 – 1444Combined sources
Beta strandi145 – 1517Combined sources
Beta strandi157 – 1615Combined sources
Helixi162 – 1643Combined sources
Turni173 – 1753Combined sources
Helixi176 – 1783Combined sources
Beta strandi180 – 1878Combined sources
Helixi193 – 21018Combined sources
Helixi230 – 2367Combined sources
Beta strandi247 – 2493Combined sources
Beta strandi257 – 2593Combined sources
Helixi265 – 28319Combined sources
Beta strandi289 – 2957Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TX1X-ray2.69A1-298[»]
ProteinModelPortaliQ8Y776.
SMRiQ8Y776. Positions 3-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 191166FAD-binding PCMH-typeUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MurB family.UniRule annotation
Contains 1 FAD-binding PCMH-type domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D4A. Bacteria.
COG0812. LUCA.
HOGENOMiHOG000284355.
KOiK00075.
OMAiLAPLTWF.
PhylomeDBiQ8Y776.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.78.10. 1 hit.
HAMAPiMF_00037. MurB. 1 hit.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERiPTHR21071. PTHR21071. 1 hit.
PfamiPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsiTIGR00179. murB. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8Y776-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNLQTKFPH IAIKLNEPLS KYTYTKTGGA ADVFVMPKTI EEAQEVVAYC
60 70 80 90 100
HQNKIPLTIL GNGSNLIIKD GGIRGVILHL DLLQTIERNN TQIVAMSGAK
110 120 130 140 150
LIDTAKFALN ESLSGLEFAC GIPGSIGGAL HMNAGAYGGE ISDVLEAATV
160 170 180 190 200
LTQTGELKKL KRSELKAAYR FSTIAEKNYI VLDATFSLAL EEKNLIQAKM
210 220 230 240 250
DELTAAREAK QPLEYPSCGS VFKRPPGHFA GKLIQDSGLQ GHIIGGAQVS
260 270 280 290
LKHAGFIVNI GGATATDYMN LIAYVQQTVR EKFDVELETE VKIIGEDK
Length:298
Mass (Da):32,206
Last modified:March 1, 2002 - v1
Checksum:i56CB7CDA15613864
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591979 Genomic DNA. Translation: CAC99498.1.
PIRiAD1252.
RefSeqiNP_464945.1. NC_003210.1.
WP_010990117.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAC99498; CAC99498; CAC99498.
GeneIDi984666.
KEGGilmo:lmo1420.
PATRICi20311965. VBILisMon69206_1459.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591979 Genomic DNA. Translation: CAC99498.1.
PIRiAD1252.
RefSeqiNP_464945.1. NC_003210.1.
WP_010990117.1. NC_003210.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3TX1X-ray2.69A1-298[»]
ProteinModelPortaliQ8Y776.
SMRiQ8Y776. Positions 3-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi169963.lmo1420.

Proteomic databases

PaxDbiQ8Y776.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC99498; CAC99498; CAC99498.
GeneIDi984666.
KEGGilmo:lmo1420.
PATRICi20311965. VBILisMon69206_1459.

Phylogenomic databases

eggNOGiENOG4105D4A. Bacteria.
COG0812. LUCA.
HOGENOMiHOG000284355.
KOiK00075.
OMAiLAPLTWF.
PhylomeDBiQ8Y776.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciLMON169963:LMO1420-MONOMER.

Family and domain databases

Gene3Di3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.78.10. 1 hit.
HAMAPiMF_00037. MurB. 1 hit.
InterProiIPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR003170. MurB.
IPR011601. MurB_C.
IPR006094. Oxid_FAD_bind_N.
[Graphical view]
PANTHERiPTHR21071. PTHR21071. 1 hit.
PfamiPF01565. FAD_binding_4. 1 hit.
PF02873. MurB_C. 1 hit.
[Graphical view]
SUPFAMiSSF56176. SSF56176. 1 hit.
SSF56194. SSF56194. 1 hit.
TIGRFAMsiTIGR00179. murB. 1 hit.
PROSITEiPS51387. FAD_PCMH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMURB_LISMO
AccessioniPrimary (citable) accession number: Q8Y776
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.