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Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei170UniRule annotation1
Active sitei220Proton donorUniRule annotation1
Active sitei290UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciLMON169963:G1GTA-1500-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation (EC:1.3.1.98UniRule annotation)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenaseUniRule annotation
Gene namesi
Name:murBUniRule annotation
Ordered Locus Names:lmo1420
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001792271 – 298UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST298

Proteomic databases

PaxDbiQ8Y776

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo1420

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 7Combined sources4
Beta strandi11 – 18Combined sources8
Helixi19 – 22Combined sources4
Beta strandi30 – 36Combined sources7
Helixi40 – 52Combined sources13
Beta strandi57 – 61Combined sources5
Beta strandi66 – 68Combined sources3
Beta strandi73 – 79Combined sources7
Beta strandi86 – 89Combined sources4
Beta strandi92 – 96Combined sources5
Helixi101 – 110Combined sources10
Beta strandi113 – 115Combined sources3
Helixi117 – 119Combined sources3
Helixi126 – 132Combined sources7
Helixi141 – 144Combined sources4
Beta strandi145 – 151Combined sources7
Beta strandi157 – 161Combined sources5
Helixi162 – 164Combined sources3
Turni173 – 175Combined sources3
Helixi176 – 178Combined sources3
Beta strandi180 – 187Combined sources8
Helixi193 – 210Combined sources18
Helixi230 – 236Combined sources7
Beta strandi247 – 249Combined sources3
Beta strandi257 – 259Combined sources3
Helixi265 – 283Combined sources19
Beta strandi289 – 295Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3TX1X-ray2.69A1-298[»]
ProteinModelPortaliQ8Y776
SMRiQ8Y776
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 191FAD-binding PCMH-typeUniRule annotationAdd BLAST166

Sequence similaritiesi

Belongs to the MurB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D4A Bacteria
COG0812 LUCA
HOGENOMiHOG000284355
KOiK00075
OMAiIGNAGSF
PhylomeDBiQ8Y776

Family and domain databases

Gene3Di3.30.43.10, 1 hit
3.90.78.10, 1 hit
HAMAPiMF_00037 MurB, 1 hit
InterProiView protein in InterPro
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR016167 FAD-bd_2_sub1
IPR003170 MurB
IPR011601 MurB_C
IPR036635 MurB_C_sf
IPR006094 Oxid_FAD_bind_N
PANTHERiPTHR21071 PTHR21071, 1 hit
PfamiView protein in Pfam
PF01565 FAD_binding_4, 1 hit
PF02873 MurB_C, 1 hit
SUPFAMiSSF56176 SSF56176, 1 hit
SSF56194 SSF56194, 1 hit
TIGRFAMsiTIGR00179 murB, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Y776-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNLQTKFPH IAIKLNEPLS KYTYTKTGGA ADVFVMPKTI EEAQEVVAYC
60 70 80 90 100
HQNKIPLTIL GNGSNLIIKD GGIRGVILHL DLLQTIERNN TQIVAMSGAK
110 120 130 140 150
LIDTAKFALN ESLSGLEFAC GIPGSIGGAL HMNAGAYGGE ISDVLEAATV
160 170 180 190 200
LTQTGELKKL KRSELKAAYR FSTIAEKNYI VLDATFSLAL EEKNLIQAKM
210 220 230 240 250
DELTAAREAK QPLEYPSCGS VFKRPPGHFA GKLIQDSGLQ GHIIGGAQVS
260 270 280 290
LKHAGFIVNI GGATATDYMN LIAYVQQTVR EKFDVELETE VKIIGEDK
Length:298
Mass (Da):32,206
Last modified:March 1, 2002 - v1
Checksum:i56CB7CDA15613864
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591979 Genomic DNA Translation: CAC99498.1
PIRiAD1252
RefSeqiNP_464945.1, NC_003210.1
WP_010990117.1, NC_003210.1

Genome annotation databases

EnsemblBacteriaiCAC99498; CAC99498; CAC99498
GeneIDi984666
KEGGilmo:lmo1420
PATRICifig|169963.11.peg.1459

Similar proteinsi

Entry informationi

Entry nameiMURB_LISMO
AccessioniPrimary (citable) accession number: Q8Y776
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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