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Q8Y766 (DAPA_LISMO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydrodipicolinate synthase
Short name=DHDPS
EC=4.2.1.52
Gene names
Name:dapA
Ordered Locus Names:lmo1435
OrganismListeria monocytogenes
Taxonomic identifier1639 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418

Subunit structure

Homotetramer By similarity. HAMAP MF_00418

Subcellular location

Cytoplasm By similarity HAMAP MF_00418.

Sequence similarities

Belongs to the DHDPS family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrodipicolinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 293293Dihydrodipicolinate synthase HAMAP MF_00418
PRO_0000103125

Regions

Region50 – 512Pyruvate binding By similarity

Sites

Active site1641Schiff-base intermediate with substrate By similarity
Binding site1091Pyruvate By similarity
Site1361Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8Y766 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: B1703AFB2ED574EE

FASTA29331,408
        10         20         30         40         50         60 
MDLGKVITAM VTPIHPEKDK VCKKRIHHLV NHLIKNGSDG LVIAGTTGES PTLSHDEKIK 

        70         80         90        100        110        120 
LFRQVIETND GRAKLIAGTG SNNTAETIAF TKEVATLGGM DAVLIVAPYY NKPNQDGLYA 

       130        140        150        160        170        180 
HFAAVAEASD LPVVIYNIPG RSVVNIEPET IIRLAKLPNI VGVKESSGNL DNISKIIAET 

       190        200        210        220        230        240 
SDDFQVYSGD DSLTLPILAV GGNGVISVAS HIVGNEMQEM IQAFERGEVQ KAAQIHRELL 

       250        260        270        280        290 
PLMNGLFSVP NPAPTKYLLN QQGISVGPVR LPLVDLNAEQ GTKLQAILEG LSK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL591979 Genomic DNA. Translation: CAC99513.1.
PIRAC1254.
RefSeqNP_464960.1. NC_003210.1.

3D structure databases

ProteinModelPortalQ8Y766.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID986494.
GenomeReviewsGene locus lmo1435 in contig AL591824_GR.
KEGGlmo:lmo1435.
PATRIC20311995. VBILisMon69206_1474.

Organism-specific databases

GenoListLMO1435.

Phylogenomic databases

HOGENOMHBG358848.
OMACEMEDSN.
ProtClustDBPRK03170.

Enzyme and pathway databases

BioCycLMON169963:LMO1435-MONOMER.

Family and domain databases

HAMAPMF_00418. DapA.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
IPR020624. Dihydrodipicolinate_synth_CS.
IPR005263. Dihydrodipicolinate_synth_DapA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01714.
PANTHERPTHR12128. DHDPS. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
TIGRFAMsTIGR00674. DapA. 1 hit.
PROSITEPS00665. DHDPS_1. 1 hit.
PS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPA_LISMO
AccessionPrimary (citable) accession number: Q8Y766
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2002
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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