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Protein

Probable manganese-dependent inorganic pyrophosphatase

Gene

ppaC

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Manganese 1UniRule annotation1
Metal bindingi13Manganese 1UniRule annotation1
Metal bindingi15Manganese 2UniRule annotation1
Metal bindingi75Manganese 1UniRule annotation1
Metal bindingi75Manganese 2UniRule annotation1
Metal bindingi97Manganese 2UniRule annotation1
Metal bindingi149Manganese 2UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciLMON169963:G1GTA-1529-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-dependent inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaCUniRule annotation
Ordered Locus Names:lmo1448
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001585771 – 308Probable manganese-dependent inorganic pyrophosphataseAdd BLAST308

Proteomic databases

PaxDbiQ8Y757
PRIDEiQ8Y757

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo1448

Structurei

3D structure databases

ProteinModelPortaliQ8Y757
SMRiQ8Y757
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2M Bacteria
COG1227 LUCA
HOGENOMiHOG000223999
KOiK15986
OMAiSTPLECW
PhylomeDBiQ8Y757

Family and domain databases

Gene3Di3.10.310.20, 1 hit
HAMAPiMF_00207 PPase_C, 1 hit
InterProiView protein in InterPro
IPR001667 DDH_dom
IPR004097 DHHA2
IPR038222 DHHA2_dom_sf
IPR022934 Mn-dep_inorganic_PyrPase
PfamiView protein in Pfam
PF01368 DHH, 1 hit
PF02833 DHHA2, 1 hit
SMARTiView protein in SMART
SM01131 DHHA2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Y757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTLVFGHK NPDTDTICSA ISYAELKKAQ GADIEAVRLG ELNSETAFVL
60 70 80 90 100
DYFQVTAPRL VQTVANEVSE VALVDHNERQ QSVDDIDDVT VTAVVDHHRI
110 120 130 140 150
ANFETSDPLY YRAEPVGCTT TILLKMFREN EVEVSKTVAG LMLSAIISDT
160 170 180 190 200
LLFQSPTCTE EDKVAAQKLA QIADVDIQSY GMEMLKAGAD VSKKTVAELL
210 220 230 240 250
LDAKEFNMND NKVEIAQINV VDVNDVLSRR AEVEALMTQN IVDKGLDLYL
260 270 280 290 300
FVITNILTND SVGIAIGSKT AVVEEAYGVK FVENQAPLKG VVSRKKQVVP

ILTDTFAK
Length:308
Mass (Da):33,761
Last modified:March 1, 2002 - v1
Checksum:iD367C1C23FE54DD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591979 Genomic DNA Translation: CAC99526.1
PIRiAH1255
RefSeqiNP_464973.1, NC_003210.1
WP_003727434.1, NC_003210.1

Genome annotation databases

EnsemblBacteriaiCAC99526; CAC99526; CAC99526
GeneIDi986727
KEGGilmo:lmo1448
PATRICifig|169963.11.peg.1487

Similar proteinsi

Entry informationi

Entry nameiPPAC_LISMO
AccessioniPrimary (citable) accession number: Q8Y757
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health