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Protein

Probable manganese-dependent inorganic pyrophosphatase

Gene

ppaC

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi9 – 91Manganese 1UniRule annotation
Metal bindingi13 – 131Manganese 1UniRule annotation
Metal bindingi15 – 151Manganese 2UniRule annotation
Metal bindingi75 – 751Manganese 1UniRule annotation
Metal bindingi75 – 751Manganese 2UniRule annotation
Metal bindingi97 – 971Manganese 2UniRule annotation
Metal bindingi149 – 1491Manganese 2UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciLMON169963:LMO1448-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable manganese-dependent inorganic pyrophosphataseUniRule annotation (EC:3.6.1.1UniRule annotation)
Alternative name(s):
Pyrophosphate phospho-hydrolaseUniRule annotation
Short name:
PPaseUniRule annotation
Gene namesi
Name:ppaCUniRule annotation
Ordered Locus Names:lmo1448
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Probable manganese-dependent inorganic pyrophosphatasePRO_0000158577Add
BLAST

Proteomic databases

PaxDbiQ8Y757.

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo1448.

Structurei

3D structure databases

ProteinModelPortaliQ8Y757.
SMRiQ8Y757. Positions 1-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase class C family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.
OrthoDBiEOG6F81QM.
PhylomeDBiQ8Y757.

Family and domain databases

HAMAPiMF_00207. PPase_C.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8Y757-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKTLVFGHK NPDTDTICSA ISYAELKKAQ GADIEAVRLG ELNSETAFVL
60 70 80 90 100
DYFQVTAPRL VQTVANEVSE VALVDHNERQ QSVDDIDDVT VTAVVDHHRI
110 120 130 140 150
ANFETSDPLY YRAEPVGCTT TILLKMFREN EVEVSKTVAG LMLSAIISDT
160 170 180 190 200
LLFQSPTCTE EDKVAAQKLA QIADVDIQSY GMEMLKAGAD VSKKTVAELL
210 220 230 240 250
LDAKEFNMND NKVEIAQINV VDVNDVLSRR AEVEALMTQN IVDKGLDLYL
260 270 280 290 300
FVITNILTND SVGIAIGSKT AVVEEAYGVK FVENQAPLKG VVSRKKQVVP

ILTDTFAK
Length:308
Mass (Da):33,761
Last modified:March 1, 2002 - v1
Checksum:iD367C1C23FE54DD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591979 Genomic DNA. Translation: CAC99526.1.
PIRiAH1255.
RefSeqiNP_464973.1. NC_003210.1.
WP_003727434.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAC99526; CAC99526; CAC99526.
GeneIDi986727.
KEGGilmo:lmo1448.
PATRICi20312021. VBILisMon69206_1487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591979 Genomic DNA. Translation: CAC99526.1.
PIRiAH1255.
RefSeqiNP_464973.1. NC_003210.1.
WP_003727434.1. NC_003210.1.

3D structure databases

ProteinModelPortaliQ8Y757.
SMRiQ8Y757. Positions 1-307.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi169963.lmo1448.

Proteomic databases

PaxDbiQ8Y757.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC99526; CAC99526; CAC99526.
GeneIDi986727.
KEGGilmo:lmo1448.
PATRICi20312021. VBILisMon69206_1487.

Phylogenomic databases

eggNOGiENOG4105E2M. Bacteria.
COG1227. LUCA.
HOGENOMiHOG000223999.
KOiK15986.
OMAiMLCAILS.
OrthoDBiEOG6F81QM.
PhylomeDBiQ8Y757.

Enzyme and pathway databases

BioCyciLMON169963:LMO1448-MONOMER.

Family and domain databases

HAMAPiMF_00207. PPase_C.
InterProiIPR001667. DDH_dom.
IPR004097. DHHA2.
IPR022934. Mn-dep_inorganic_PyrPase.
[Graphical view]
PfamiPF01368. DHH. 1 hit.
PF02833. DHHA2. 1 hit.
[Graphical view]
SMARTiSM01131. DHHA2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiPPAC_LISMO
AccessioniPrimary (citable) accession number: Q8Y757
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.