Q8Y733 (Q8Y733_LISMO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase 2 HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE2 HAMAP MF_00222
Ordered Locus Names:	lmo1490

Organism

Listeria monocytogenes

Taxonomic identifier

1639 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222 SAAS SAAS011342
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222 SAAS SAAS011342
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222 SAAS SAAS011342
Ligand	NADP HAMAP MF_00222 SAAS SAAS011342
Molecular function	Oxidoreductase RuleBase RU004037 HAMAP MF_00222 SAAS SAAS011342
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	125 – 129	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	65	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	Q8Y733 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: CF29C8AC67043EED	FASTA	273	29,972
	10 20 30 40 50 60 MEKYVVIGNP IRHSLSPAMQ NRIFQELGMN AEYNSVLIEE DAFETEIKKL MDSGVRGFNI 70 80 90 100 110 120 TTPFKERILP FLDELDNLAA ASGAVNTVLK KEDKWYGFNT DGKGYLEGLE EIRSITEDDS 130 140 150 160 170 180 ILITGAGGAS KAIYLALSTH TDAKITVANR TTEKAIEMTK DNNNHHAITL EEAEKQLADF 190 200 210 220 230 240 TIIIQTTSIG LEASKNKSPI SLANVKQGTI CSDIIYNPAE TAFLKEAKKN GAITQNGLPM 250 260 270 FVNQGALAFE IWTGIKPERS LMKEAVLEQL GGN

References

[1]

"Comparative genomics of Listeria species." Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., Dominguez-Bernal G., Duchaud E. , Durant L., Dussurget O., Entian K.-D., Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W., Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U., Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A., Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P. Science 294:849-852(2001) [PubMed: 11679669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-679 / EGD-e / Serovar 1/2a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL591979 Genomic DNA. Translation: CAC99568.1.
PIR	AB1261.
RefSeq	NP_465015.1. NC_003210.1.
3D structure databases
HSSP	HSSP built from PDB template 1NVT based on UniProtKB Q58484.
ProteinModelPortal	Q8Y733.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	986965.
GenomeReviews	Gene locus lmo1490 in contig AL591824_GR.
KEGG	lmo:lmo1490.
PATRIC	20312107. VBILisMon69206_1530.
Organism-specific databases
GenoList	LMO1490.
Phylogenomic databases
HOGENOM	HBG553408.
OMA	FERWFGI.
ProtClustDB	CLSK564450.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q8Y733_LISMO

Accession

Primary (citable) accession number: Q8Y733

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	December 14, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)