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Q8Y6Z6 (LDH2_LISMO) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
L-lactate dehydrogenase 2

Short name=L-LDH 2
EC=1.1.1.27
Gene names
Name:ldh2
Ordered Locus Names:lmo1534
OrganismListeria monocytogenes
Taxonomic identifier1639 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesListeriaceaeListeria

Protein attributes

Sequence length311 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-lactate + NAD+ = pyruvate + NADH. HAMAP MF_00488

Pathway

Fermentation; pyruvate fermentation to lactate; (S)-lactate from pyruvate: step 1/1. HAMAP MF_00488

Subunit structure

Homotetramer By similarity. HAMAP MF_00488

Subcellular location

Cytoplasm By similarity HAMAP MF_00488.

Sequence similarities

Belongs to the LDH/MDH superfamily. LDH family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionL-lactate dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 311311L-lactate dehydrogenase 2 HAMAP MF_00488
PRO_0000168366

Regions

Nucleotide binding12 – 4029NAD By similarity

Sites

Active site1771Proton acceptor By similarity
Binding site901Substrate By similarity
Binding site1221NAD or substrate By similarity
Binding site1531Substrate By similarity
Binding site2301Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8Y6Z6 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: D7DB065307C8E301

FASTA31133,741
        10         20         30         40         50         60 
MKPRKVMIIG AGNVGTAAAH AFVNQKFVEE LILVDLNKER VEGNRKDLAD AAAFMPGKMD 

        70         80         90        100        110        120 
ITVRDASDCA DVDIAVITVT AGPLKEGQTR LDELRSTSRI VSGIVPEMMK GGFNGIFLIA 

       130        140        150        160        170        180 
TNPCDIITYQ VWKLSGLPRE RVLGTGVWLD TTRLRRLLAE KLDIAAQSID AFILGEHGDS 

       190        200        210        220        230        240 
QFPVWSHSSI YGKPVNEYSL EKLGESLDLK QIGETARDTG FEIYHQKGCT EYGIGGTIVE 

       250        260        270        280        290        300 
ICRHIFSGSQ RALTVSCVLD GEYGESGLAI GVPAVLSQNG VKEIISLKLD EQEQQAFANS 

       310 
VSVIKKSIAS I 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591979 Genomic DNA. Translation: CAC99612.1.
PIRAF1266.
RefSeqNP_465059.1. NC_003210.1.

3D structure databases

ProteinModelPortalQ8Y6Z6.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID987808.
GenomeReviewsGene locus lmo1534 in contig AL591824_GR.
KEGGlmo:lmo1534.
PATRIC20312197. VBILisMon69206_1575.

Organism-specific databases

GenoListLMO1534.

Phylogenomic databases

HOGENOMHBG566126.
OMANEYSMEK.
ProtClustDBCLSK895005.

Enzyme and pathway databases

BioCycLMON169963:LMO1534-MONOMER.

Family and domain databases

HAMAPMF_00488. Lactate_dehydrog.
[Tree]
InterProIPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.90.110.10. lact_mal_DH. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00016.
PANTHERPTHR11540:SF3. PTHR11540:SF3. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01771. L-LDH-NAD. 1 hit.
PROSITEPS00064. L_LDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLDH2_LISMO
AccessionPrimary (citable) accession number: Q8Y6Z6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: March 1, 2002
Last modified: January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families