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Q8Y6X8

- GSA1_LISMO

UniProt

Q8Y6X8 - GSA1_LISMO

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase 1

Gene
hemL1, lmo1553
Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciLMON169963:LMO1553-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase 1 (EC:5.4.3.8)
Short name:
GSA 1
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase 1
Short name:
GSA-AT 1
Gene namesi
Name:hemL1
Ordered Locus Names:lmo1553
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000817: Chromosome

Organism-specific databases

GenoListiLMO1553.

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 429429Glutamate-1-semialdehyde 2,1-aminomutase 1UniRule annotationPRO_0000120419Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei268 – 2681N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi169963.lmo1553.

Structurei

3D structure databases

ProteinModelPortaliQ8Y6X8.
SMRiQ8Y6X8. Positions 36-425.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRAIKPYP.
OrthoDBiEOG6QVRHN.
PhylomeDBiQ8Y6X8.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8Y6X8-1 [UniParc]FASTAAdd to Basket

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MQNYSKSEKA FKEAKKVLPG GVNSPVRAFN SVDASPVFMD HGKGAYITDV    50
DGNEYIDYVL SWGPLILGHT DPAVVNAITK AALKGTSFGT PTEIETELAK 100
LVIERVPSIE IVRMVSSGTE ATMSAIRLAR GYTKREKILK FEGSYHGHGD 150
SLLIKAGSGV ATLGLPDSPG VTKGLAADTI TVPYNDIEGA KLAFEKYGEE 200
IAAVIVEPVA GNMGVVPPIE GFLEGLRELT TKFGSLLIFD EVMTGFRVDY 250
YSAQGYYVVT PDLTCLGKVI GGGLPVGAYG GKKEIMEQIA PAGSIYQAGT 300
LSGNPLAMNA GFETVRQLTP QHYDVFRTLI KRMEEGLTEI SARRQVPLSI 350
NKAGSMFGFF FTDQKVINFD TAKTSNLEFF RNYYREMLGQ GIFLPPSQFE 400
GVFISTMHTE NEIDKTLEAF DTTCKILRG 429
Length:429
Mass (Da):46,603
Last modified:March 1, 2002 - v1
Checksum:i3CEBE0CB96658E9D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591979 Genomic DNA. Translation: CAC99631.1.
PIRiAI1268.
RefSeqiNP_465078.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAC99631; CAC99631; CAC99631.
GeneIDi986918.
KEGGilmo:lmo1553.
PATRICi20312235. VBILisMon69206_1594.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591979 Genomic DNA. Translation: CAC99631.1 .
PIRi AI1268.
RefSeqi NP_465078.1. NC_003210.1.

3D structure databases

ProteinModelPortali Q8Y6X8.
SMRi Q8Y6X8. Positions 36-425.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 169963.lmo1553.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC99631 ; CAC99631 ; CAC99631 .
GeneIDi 986918.
KEGGi lmo:lmo1553.
PATRICi 20312235. VBILisMon69206_1594.

Organism-specific databases

GenoListi LMO1553.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RAIKPYP.
OrthoDBi EOG6QVRHN.
PhylomeDBi Q8Y6X8.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci LMON169963:LMO1553-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiGSA1_LISMO
AccessioniPrimary (citable) accession number: Q8Y6X8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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