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Q8Y6J9

- GSA2_LISMO

UniProt

Q8Y6J9 - GSA2_LISMO

Protein

Glutamate-1-semialdehyde 2,1-aminomutase 2

Gene

hemL2

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro
    3. transaminase activity Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciLMON169963:LMO1685-MONOMER.
    UniPathwayiUPA00251; UER00317.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate-1-semialdehyde 2,1-aminomutase 2UniRule annotation (EC:5.4.3.8UniRule annotation)
    Short name:
    GSA 2UniRule annotation
    Alternative name(s):
    Glutamate-1-semialdehyde aminotransferase 2UniRule annotation
    Short name:
    GSA-AT 2UniRule annotation
    Gene namesi
    Name:hemL2UniRule annotation
    Synonyms:gsaB
    Ordered Locus Names:lmo1685
    OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
    Taxonomic identifieri169963 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
    ProteomesiUP000000817: Chromosome

    Organism-specific databases

    GenoListiLMO1685.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 432432Glutamate-1-semialdehyde 2,1-aminomutase 2PRO_0000120422Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei268 – 2681N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi169963.lmo1685.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8Y6J9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0001.
    HOGENOMiHOG000020210.
    KOiK01845.
    OMAiETRANGM.
    OrthoDBiEOG6QVRHN.
    PhylomeDBiQ8Y6J9.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPiMF_00375. HemL_aminotrans_3.
    InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PANTHERiPTHR11986. PTHR11986. 1 hit.
    PfamiPF00202. Aminotran_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR00713. hemL. 1 hit.
    PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8Y6J9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDHSMSKKLH DEALLHIVGG VNSPSRSNKG VGGGIPVTME RASGAYFYDV    50
    DGNKYIDYLA AFGPIITGHA HPHITEAITK AAQNGVLYGT PTKHEITFAK 100
    MLKEAIPSLE KVRFTNSGTE AVMTTIRVAR AYTGRDKIIK FAGCYHGHFD 150
    LVLVEAGSGP STLGIPDSAG VTKSTAEEVI TVPFNDLDSF KEALAIWGDQ 200
    VAAVLVEPIV GNFGMVAPED GFLEAVNELA HVNGSLVIYD EVITAFRFMY 250
    GGAQNYLGVI PDLTAMGKII GGGLPIGAYG GRIDIMEKVA PLGPAYQAGT 300
    HAGNPASILS GIACLEVLQE EGLYERFEKY GSMLKDGIEK AAAKHNIAVT 350
    VNQIVGALTV YFTEDPVTNY AEAGATNGEL FGRFFKGMLE EGINLAPSKY 400
    EAWFITSAHS EADILETIQA VDTVFGKMVQ DN 432
    Length:432
    Mass (Da):46,101
    Last modified:March 1, 2002 - v1
    Checksum:i127E7DA9790E8A61
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591980 Genomic DNA. Translation: CAC99763.1.
    PIRiAE1285.
    RefSeqiNP_465210.1. NC_003210.1.

    Genome annotation databases

    EnsemblBacteriaiCAC99763; CAC99763; CAC99763.
    GeneIDi985629.
    KEGGilmo:lmo1685.
    PATRICi20312551. VBILisMon69206_1728.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL591980 Genomic DNA. Translation: CAC99763.1 .
    PIRi AE1285.
    RefSeqi NP_465210.1. NC_003210.1.

    3D structure databases

    ProteinModelPortali Q8Y6J9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 169963.lmo1685.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAC99763 ; CAC99763 ; CAC99763 .
    GeneIDi 985629.
    KEGGi lmo:lmo1685.
    PATRICi 20312551. VBILisMon69206_1728.

    Organism-specific databases

    GenoListi LMO1685.

    Phylogenomic databases

    eggNOGi COG0001.
    HOGENOMi HOG000020210.
    KOi K01845.
    OMAi ETRANGM.
    OrthoDBi EOG6QVRHN.
    PhylomeDBi Q8Y6J9.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00317 .
    BioCyci LMON169963:LMO1685-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 2 hits.
    HAMAPi MF_00375. HemL_aminotrans_3.
    InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
    IPR005814. Aminotrans_3.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    PANTHERi PTHR11986. PTHR11986. 1 hit.
    Pfami PF00202. Aminotran_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR00713. hemL. 1 hit.
    PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-679 / EGD-e.

    Entry informationi

    Entry nameiGSA2_LISMO
    AccessioniPrimary (citable) accession number: Q8Y6J9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3