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Q8Y6C5 (PUR9_LISMO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:lmo1765
OrganismListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) [Reference proteome] [HAMAP]
Taxonomic identifier169963 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192103

Sequences

Sequence LengthMass (Da)Tools
Q8Y6C5 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 707FCBFB7A4BBC0B

FASTA50955,000
        10         20         30         40         50         60 
MKRALISVSD KNGIVPFAEK LVELGVEIIS TGGTKAAFEQ AGVPVTGIEE VTEFPEMLDG 

        70         80         90        100        110        120 
RVKTLHPAIH GGLLARRDTA EHMEAIAAHN IKPIDLVIVN LYPFQETIQK PGVTLEEAIE 

       130        140        150        160        170        180 
NIDIGGPSML RSAAKNYAAV TVVVDTADYD AVLTELQEHG ATTFETRQRL AAKVFRHTAA 

       190        200        210        220        230        240 
YDALIAEYLT NITGETFPEK VTFTYNRKQV LRYGENPHQD AAFYTEPGTI ENSISAAKQL 

       250        260        270        280        290        300 
HGKELSYNNI RDADAALKIA SEFTEPVAVA VKHMNPCGVG VGENIEEAYL KAYEADETSI 

       310        320        330        340        350        360 
FGGIVALNKE VDAKTAEHMS KIFLEIVIAP SFSEEAFAIL AKKKNIRLLT VPFAGNMEGF 

       370        380        390        400        410        420 
EKTSVNGGLL IQANDSLVED TTSYEVVTEK QPTDSEMKAL LAQWKIVKHV KSNAIVVGSD 

       430        440        450        460        470        480 
KQTLGIGAGQ MNRIGSALIA LEQAGEKAKG AVLASDAFFP MDDTVEAAAK SGITAIIQPG 

       490        500 
GSIKDKESIA MADKYGISMV LTHVRHFKH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591981 Genomic DNA. Translation: CAC99843.1.
PIRAE1295.
RefSeqNP_465290.1. NC_003210.1.

3D structure databases

ProteinModelPortalQ8Y6C5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING169963.lmo1765.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC99843; CAC99843; CAC99843.
GeneID985977.
KEGGlmo:lmo1765.
PATRIC20312715. VBILisMon69206_1809.

Organism-specific databases

GenoListLMO1765.

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMARAFKTDP.
OrthoDBEOG6QCDFF.
PhylomeDBQ8Y6C5.

Enzyme and pathway databases

BioCycLMON169963:LMO1765-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_LISMO
AccessionPrimary (citable) accession number: Q8Y6C5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways