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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylformylglycinamidine synthase subunit PurS (purS), Phosphoribosylformylglycinamidine synthase subunit PurL (purL), Phosphoribosylformylglycinamidine synthase subunit PurQ (purQ)
  2. Phosphoribosylformylglycinamidine cyclo-ligase (purM)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLMON169963:G1GTA-1889-MONOMER
UniPathwayiUPA00074; UER00129

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:lmo1767
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000000817 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001482231 – 349Phosphoribosylformylglycinamidine cyclo-ligaseAdd BLAST349

Proteomic databases

PaxDbiQ8Y6C3

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo1767

Structurei

3D structure databases

ProteinModelPortaliQ8Y6C3
SMRiQ8Y6C3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CXB Bacteria
COG0150 LUCA
KOiK01933
OMAiNHCVNDI
PhylomeDBiQ8Y6C3

Family and domain databases

CDDicd02196 PurM, 1 hit
Gene3Di3.30.1330.101 hit
3.90.650.101 hit
HAMAPiMF_00741 AIRS, 1 hit
InterProiView protein in InterPro
IPR010918 PurM-like_C_dom
IPR036676 PurM-like_C_sf
IPR016188 PurM-like_N
IPR036921 PurM-like_N_sf
IPR004733 PurM_cligase
PANTHERiPTHR10520 PTHR10520, 1 hit
PfamiView protein in Pfam
PF00586 AIRS, 1 hit
PF02769 AIRS_C, 1 hit
SUPFAMiSSF55326 SSF55326, 1 hit
SSF56042 SSF56042, 1 hit
TIGRFAMsiTIGR00878 purM, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Y6C3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENAYSKAG VDVEAGYQVV ERIKKHVART ERIGAMGALG SFGGMFDLSS
60 70 80 90 100
LNLKEPVLVS GTDGVGTKLL LAIEADKHDT IGIDCVAMCV NDILAQGAEP
110 120 130 140 150
LFFLDYIATG KTDPVKMEQI VKGVADGCEQ AGAALIGGET AEMPDMYGAD
160 170 180 190 200
DYDLAGFTVG AVEKQKLITE GAVQAGDTLI GIPSSGIHSN GYSLVRKIFF
210 220 230 240 250
KDNEFTLDAE ISELDVPLVE ELLKPTRIYV KPVLEVLKEV TVHGITHVTG
260 270 280 290 300
GGFVENLPRM LTNDLAVKVE LGSWPMLPIF DVVKKYGQLN EMEMYEIFNM
310 320 330 340
GIGMVLAVAK SDVEKTLEVL VQNGEAAYVI GEVTTRESNA VIFAGGKKG
Length:349
Mass (Da):37,342
Last modified:March 1, 2002 - v1
Checksum:iD7A47D02E978DCFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591981 Genomic DNA Translation: CAC99845.1
PIRiAG1295
RefSeqiNP_465292.1, NC_003210.1
WP_009933235.1, NC_003210.1

Genome annotation databases

EnsemblBacteriaiCAC99845; CAC99845; CAC99845
GeneIDi985975
KEGGilmo:lmo1767
PATRICifig|169963.11.peg.1811

Similar proteinsi

Entry informationi

Entry nameiPUR5_LISMO
AccessioniPrimary (citable) accession number: Q8Y6C3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2002
Last modified: February 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome