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Q8Y6C3 (PUR5_LISMO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine cyclo-ligase

EC=6.3.3.1
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene names
Name:purM
Ordered Locus Names:lmo1767
OrganismListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e) [Reference proteome] [HAMAP]
Taxonomic identifier169963 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00741.

Sequence similarities

Belongs to the AIR synthase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoribosylformylglycinamidine cyclo-ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741
PRO_0000148223

Sequences

Sequence LengthMass (Da)Tools
Q8Y6C3 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: D7A47D02E978DCFC

FASTA34937,342
        10         20         30         40         50         60 
MAENAYSKAG VDVEAGYQVV ERIKKHVART ERIGAMGALG SFGGMFDLSS LNLKEPVLVS 

        70         80         90        100        110        120 
GTDGVGTKLL LAIEADKHDT IGIDCVAMCV NDILAQGAEP LFFLDYIATG KTDPVKMEQI 

       130        140        150        160        170        180 
VKGVADGCEQ AGAALIGGET AEMPDMYGAD DYDLAGFTVG AVEKQKLITE GAVQAGDTLI 

       190        200        210        220        230        240 
GIPSSGIHSN GYSLVRKIFF KDNEFTLDAE ISELDVPLVE ELLKPTRIYV KPVLEVLKEV 

       250        260        270        280        290        300 
TVHGITHVTG GGFVENLPRM LTNDLAVKVE LGSWPMLPIF DVVKKYGQLN EMEMYEIFNM 

       310        320        330        340 
GIGMVLAVAK SDVEKTLEVL VQNGEAAYVI GEVTTRESNA VIFAGGKKG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL591981 Genomic DNA. Translation: CAC99845.1.
PIRAG1295.
RefSeqNP_465292.1. NC_003210.1.

3D structure databases

ProteinModelPortalQ8Y6C3.
SMRQ8Y6C3. Positions 14-331.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING169963.lmo1767.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC99845; CAC99845; CAC99845.
GeneID985975.
KEGGlmo:lmo1767.
PATRIC20312719. VBILisMon69206_1811.

Organism-specific databases

GenoListLMO1767.

Phylogenomic databases

eggNOGCOG0150.
KOK01933.
OMAHCVNDIL.
OrthoDBEOG61CM1V.
ProtClustDBPRK05385.

Enzyme and pathway databases

BioCycLMON169963:LMO1767-MONOMER.
UniPathwayUPA00074; UER00129.

Family and domain databases

Gene3D3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPMF_00741_B. AIRS_B.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsTIGR00878. purM. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR5_LISMO
AccessionPrimary (citable) accession number: Q8Y6C3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways