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Q8Y5N9

- DAPF_LISMO

UniProt

Q8Y5N9 - DAPF_LISMO

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Protein
Diaminopimelate epimerase
Gene
dapF, lmo2018
Organism
Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei14 – 141Substrate By similarity
Binding sitei53 – 531Substrate By similarity
Binding sitei73 – 731Substrate By similarity
Active sitei82 – 821Proton donor/acceptor By similarity
Binding sitei170 – 1701Substrate By similarity
Sitei172 – 1721Important for catalytic activity By similarity
Binding sitei206 – 2061Substrate By similarity
Sitei224 – 2241Important for catalytic activity By similarity
Active sitei233 – 2331Proton donor/acceptor By similarity

GO - Molecular functioni

  1. diaminopimelate epimerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

BioCyciLMON169963:LMO2018-MONOMER.
UniPathwayiUPA00034; UER00025.

Names & Taxonomyi

Protein namesi
Recommended name:
Diaminopimelate epimerase (EC:5.1.1.7)
Short name:
DAP epimerase
Gene namesi
Name:dapF
Ordered Locus Names:lmo2018
OrganismiListeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
Taxonomic identifieri169963 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
ProteomesiUP000000817: Chromosome

Organism-specific databases

GenoListiLMO2018.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Diaminopimelate epimeraseUniRule annotation
PRO_0000149851Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi82 ↔ 233UniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Protein-protein interaction databases

STRINGi169963.lmo2018.

Structurei

3D structure databases

ProteinModelPortaliQ8Y5N9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 843Substrate binding By similarity
Regioni224 – 2252Substrate binding By similarity
Regioni234 – 2352Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0253.
HOGENOMiHOG000220466.
KOiK01778.
OMAiKDITVMV.
OrthoDBiEOG6ND0M5.
PhylomeDBiQ8Y5N9.

Family and domain databases

HAMAPiMF_00197. DAP_epimerase.
InterProiIPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view]
PANTHERiPTHR31689. PTHR31689. 1 hit.
PfamiPF01678. DAP_epimerase. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00652. DapF. 1 hit.
PROSITEiPS01326. DAP_EPIMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8Y5N9-1 [UniParc]FASTAAdd to Basket

« Hide

MATIHFTKVH GSQNDFFLVD EEGNQIMDWS DAKRADFAIK LCDREHSLGG    50
ADGILYVTKS SEAGPIGQMR VVNSDGSIAS MCGNGLRTVA RYLLEKHALT 100
EAKVETMKAI LDVKKATSLG FDIPTYQVEI SPVKFNAESL PMNVGVEKLF 150
NQVVPELDAE LAFSAVSVPN PHLITFVDQT VLDSDRQETL ASYLNSENPY 200
FPDGVNVSFV KRLSDDAIYV RTFERGVGFT NACGTAMSAC SLIKKMLDKD 250
TFETPLNVYN DGGRVQVTAK KDEAGDISLQ LIGNATFVST GSVSYESDTV 300
TELTNEATPE QAQYQELVKE VKEFLKTTE 329
Length:329
Mass (Da):36,071
Last modified:March 1, 2002 - v1
Checksum:i9B5992BFDAEA83CD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591981 Genomic DNA. Translation: CAD00096.1.
PIRiAB1327.
RefSeqiNP_465542.1. NC_003210.1.

Genome annotation databases

EnsemblBacteriaiCAD00096; CAD00096; CAD00096.
GeneIDi985823.
KEGGilmo:lmo2018.
PATRICi20313235. VBILisMon69206_2066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL591981 Genomic DNA. Translation: CAD00096.1 .
PIRi AB1327.
RefSeqi NP_465542.1. NC_003210.1.

3D structure databases

ProteinModelPortali Q8Y5N9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 169963.lmo2018.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD00096 ; CAD00096 ; CAD00096 .
GeneIDi 985823.
KEGGi lmo:lmo2018.
PATRICi 20313235. VBILisMon69206_2066.

Organism-specific databases

GenoListi LMO2018.

Phylogenomic databases

eggNOGi COG0253.
HOGENOMi HOG000220466.
KOi K01778.
OMAi KDITVMV.
OrthoDBi EOG6ND0M5.
PhylomeDBi Q8Y5N9.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00025 .
BioCyci LMON169963:LMO2018-MONOMER.

Family and domain databases

HAMAPi MF_00197. DAP_epimerase.
InterProi IPR018510. DAP_epimerase_AS.
IPR001653. DAP_epimerase_DapF.
[Graphical view ]
PANTHERi PTHR31689. PTHR31689. 1 hit.
Pfami PF01678. DAP_epimerase. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR00652. DapF. 1 hit.
PROSITEi PS01326. DAP_EPIMERASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-679 / EGD-e.

Entry informationi

Entry nameiDAPF_LISMO
AccessioniPrimary (citable) accession number: Q8Y5N9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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